Renin and prorenin disappearance in humans post-nephrectomy: evidence for binding?

Autor: Frans H.M. Derkx, Manne Krop, de Bruyn Jh, Alexander H. J. Danser

Publikováno v: Frontiers in Bioscience, 13, 3931-3939. Frontiers in Bioscience

To study the distribution of kidney-derived renin-angiotensin system (RAS) components in humans, we monitored the decline in plasma prorenin, renin, angiotensin (Ang) I and Ang II post-nephrectomy. Prorenin and renin decreased biphasically, prorenin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e07bfa4f840aa620620b65ff779a1a8
https://doi.org/10.2741/2981

Renal Secretion of Inactive Renin

Autor: M. A. D. H. Schalekamp, R. P. Verhoeven, A. J. Man In 'T Veld, Frans H.M. Derkx, G. J. Wenting

Human plasma contains a non-dialyzable factor which is not enzymatically active in its native form but shows renin-like activity after exposure to low pH (inactive renin). In 3 out of 13 patients with renovascular hypertension the renal to peripheral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::874d7babe20d9f384c37205943b360b4
https://doi.org/10.1159/000401797

Prorenin Accumulation and Activation in Human Endothelial Cells

Autor: Wim Sluiter, Timothy L. Reudelhuber, A.H. Jan Danser, Jasper J. Saris, Elly A. de Wit, Maarten A.D.H. Schalekamp, Frans H.M. Derkx, René J.A. de Bruin, Mark M. E. D. van den Eijnden

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 21:911-916

Abstract —ACE inhibitors improve endothelial dysfunction, possibly by blocking endothelial angiotensin production. Prorenin, through its binding and activation by endothelial mannose 6-phosphate (M6P) receptors, may contribute to this production. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715fbc772d510574606bd6fd058d49cf
https://doi.org/10.1161/01.atv.21.6.911

Resistance to antihypertensive medication as predictor of renal artery stenosis: comparison of two drugregimens

Autor: A J Woittiez, Pieta Krijnen, M. A. D. H. Schalekamp, Frans H.M. Derkx, B C van Jaarsveld, J. Deinum, Cornelis T. Postma

Publikováno v: Journal of Human Hypertension, 15, 10, pp. 669--76
Journal of Human Hypertension, 15, 669--76
Journal of Human Hypertension, 15, 669-676. Nature Publishing Group
Van Jaarsveld, B C, Krijnen, P, Derkx, F H M, Deinum, J, Woittiez, A J J, Postma, C T & Schalekamp, M A D H 2001, ' Resistance to antihypertensive medication as predictor of renal artery stenosis : Comparison of two drug regimens ', Journal of Human Hypertension, vol. 15, no. 10, pp. 669-676 . https://doi.org/10.1038/sj.jhh.1001258
Journal of Human Hypertension, 15(10), 669-676. Nature Publishing Group

Item does not contain fulltext BACKGROUND: Renal artery stenosis is among the most common curable causes of hypertension. The definitive diagnosis is made by renal angiography, an invasive and costly procedure. The prevalence of renal artery stenosis

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https://pure.eur.nl/en/publications/3ab39090-d1c1-4286-a586-2ce2c85f2999

The effect of balloon angioplasty on hypertension in atherosclerotic renal-artery stenosis

Autor: Herman Pieterman, Ad Dees, Brigit C. Van Jaarsveld, Arie J. Man in 't Veld, Jaap Deinum, Cornelis T. Postma, Maarten A.D.H. Schalekamp, Frans H.M. Derkx, Pieta Krijnen, Arend J.J. Woittiez, A. K. M. Bartelink

Publikováno v: The New England Journal of Medicine, 342, 1007-1014
New England Journal of Medicine, 342(14), 1007-1014. Massachussetts Medical Society
The New England Journal of Medicine, 342, pp. 1007-1014

Background Patients with hypertension and renal-artery stenosis are often treated with percutaneous transluminal renal angioplasty. However, the long-term effects of this procedure on blood pressure are not well understood. Methods We randomly assign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01985ff8cedfd87404de24711f7f376b
https://doi.org/10.1056/nejm200004063421403