Zobrazeno 1 - 10
of 302
pro vyhledávání: '"Frans G. M. Russel"'
Autor:
Tim Somers, Neeltje A. E. Allard, Sailay Siddiqi, Margit C. M. Janssen, Maria T. E. Hopman, Wim J. Morshuis, Frans G. M. Russel, Silvie Timmers, Tom J. J. Schirris
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Drug-induced mitochondrial dysfunction is a common adverse effect, particularly in case of statins—the most prescribed drugs worldwide. These drugs have been shown to inhibit complex III (CIII) of the mitochondrial oxidative phosphorylatio
Externí odkaz:
https://doaj.org/article/07377571bfc6436db3445afffa3a5dad
Autor:
Eva J. Streekstra, Márton Kiss, Jeroen van denHeuvel, Johan Nicolaï, Petra van denBroek, Sanne M. B. I. Botden, Martijn W. J. Stommel, Lara vanRijssel, Anna‐Lena Ungell, Evita van deSteeg, Frans G. M. Russel, Saskia N. deWildt
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 10, Pp 2392-2402 (2022)
Abstract Little is known about the impact of age on the processes governing human intestinal drug absorption. The Ussing chamber is a system to study drug transport across tissue barriers, but it has not been used to study drug absorption processes i
Externí odkaz:
https://doaj.org/article/19dc0c00bdde4a0c98ee0dc9ad49aa34
Autor:
Noor E. Verhagen, Jan B. Koenderink, Nicole M. A. Blijlevens, Jeroen J. W. M. Janssen, Frans G. M. Russel
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2535 (2023)
Chronic myeloid leukemia (CML) is a hematologic neoplasm characterized by the expression of the BCR::ABL1 oncoprotein, a constitutively active tyrosine kinase, resulting in uncontrolled growth and proliferation of cells in the myeloid lineage. Target
Externí odkaz:
https://doaj.org/article/ecae994a797a441589e8232b857ff9c3
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 10, Iss 10, p 417 (2023)
Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, and are the cornerstone of lipid-lowering treatment. They significantly reduce cardiovascular morbidity and mortality. However, musculoskeletal symptoms are observe
Externí odkaz:
https://doaj.org/article/0369d11886e34b0fbea49a9a76ae6a9e
Autor:
Carlijn H. C. Litjens, Laurens F. M. Verscheijden, Elin M. Svensson, Petra H. H. van den Broek, Hedwig van Hove, Jan B. Koenderink, Frans G. M. Russel, Rob E. Aarnoutse, Lindsey H. M. te Brake
Publikováno v:
Antibiotics, Vol 12, Iss 4, p 702 (2023)
Linezolid is used off-label for treatment of central nervous system infections. However, its pharmacokinetics and target attainment in cranial cerebrospinal fluid (CSF) in tuberculous meningitis patients is unknown. This study aimed to predict linezo
Externí odkaz:
https://doaj.org/article/1cda5fe5ffa44c3da3aedc061453a16f
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Fourteen to 26 percent of all hospitalized cases of acute kidney injury are explained by drug-induced toxicity, emphasizing the importance of proper strategies to pre-clinically assess renal toxicity. The MTT assay is widely used as a measure of cell
Externí odkaz:
https://doaj.org/article/ccdecf3852684e1fbe255f1219a61346
Autor:
Maarten van der Velden, Albert Bilos, Jeroen J. M. W. van den Heuvel, Sanna R. Rijpma, Evelien G. E. Hurkmans, Robert W. Sauerwein, Frans G. M. Russel, Jan B. Koenderink
Publikováno v:
Malaria Journal, Vol 16, Iss 1, Pp 1-12 (2017)
Abstract Background Malaria, HIV/AIDS, and tuberculosis endemic areas show considerable geographical overlap, leading to incidence of co-infections. This requires treatment with multiple drugs, potentially causing adverse drug–drug interactions (DD
Externí odkaz:
https://doaj.org/article/b27f86145f49479db057cc1f0f96e3c4
Autor:
Nori J. L. Smeets, Carlijn H. C. Litjens, Jeroen J. M. W. van den Heuvel, Hedwig van Hove, Petra van den Broek, Frans G. M. Russel, Jan B. Koenderink, Saskia N. de Wildt
Publikováno v:
Pharmaceutics, Vol 12, Iss 10, p 935 (2020)
Background: Enalapril is often used in the treatment of cardiovascular diseases. Clinical data suggest that the urinary excretion of enalaprilat, the active metabolite of enalapril, is mediated by renal transporters. We aimed to identify enalaprilat
Externí odkaz:
https://doaj.org/article/044f751e0f7e4c77bcf1c387e2aa60ef
Autor:
Miriam Huls, Joost P. H. Schoeber, Catherine M. Verfaillie, Aernout Luttun, Fernando Ulloa-Montoya, Aswin L. Menke, Lars R. Van Bolderen, Rob M. Woestenenk, Gerard F. M. Merkx, Jack F. M. Wetzels, Frans G. M. Russel, Rosalinde Masereeuw Ph.D.
Publikováno v:
Cell Transplantation, Vol 19 (2010)
Externí odkaz:
https://doaj.org/article/03275398f80c49ff9614e3c980e11c48
Autor:
Karel H van der Pol, Jan Koenderink, Jeroen J M W van den Heuvel, Petra van den Broek, Janny Peters, Imke D W van Bunningen, Jeanne Pertijs, Frans G M Russel, Jim Koldenhof, Wim J Morshuis, Joris van Drongelen, Tom J J Schirris, Andries van der Meer, Gerard A Rongen
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0305906 (2024)
Uric acid induces radical oxygen species formation, endothelial inflammation, and endothelial dysfunction which contributes to the progression of atherosclerosis. Febuxostat inhibits BCRP- and allopurinol stimulates MRP4-mediated uric acid efflux in
Externí odkaz:
https://doaj.org/article/fd27e0ee1021449984bd8991649ed5a0