Physiologically based pharmacokinetic/pharmacodynamic model for the prediction of morphine brain disposition and analgesia in adults and children.

Autor: Laurens F M Verscheijden, Carlijn H C Litjens, Jan B Koenderink, Ron H J Mathijssen, Marcel M Verbeek, Saskia N de Wildt, Frans G M Russel

Publikováno v: PLoS Computational Biology, Vol 17, Iss 3, p e1008786 (2021)

Morphine is a widely used opioid analgesic, which shows large differences in clinical response in children, even when aiming for equivalent plasma drug concentrations. Age-dependent brain disposition of morphine could contribute to this variability,

Externí odkaz: https://doaj.org/article/453e7f115c204fa085ec5f77bb94a806

Uremic Solutes in Chronic Kidney Disease and Their Role in Progression.

Autor: Jan A J G van den Brand, Henricus A M Mutsaers, Arjan D van Zuilen, Peter J Blankestijn, Petra H van den Broek, Frans G M Russel, Rosalinde Masereeuw, Jack F M Wetzels

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0168117 (2016)

To date, over 150 possible uremic solutes have been listed, but their role in the progression of CKD is largely unknown. Here, the association between a selected panel of uremic solutes and progression in CKD patients was investigated.Patients from t

Externí odkaz: https://doaj.org/article/6044e7fb22b148d4a9a0889241bac67f

Identification of novel translational urinary biomarkers for acetaminophen-induced acute liver injury using proteomic profiling in mice.

Autor: Rachel P L van Swelm, Coby M M Laarakkers, Ellen C van der Kuur, Eva Morava-Kozicz, Ron A Wevers, Kevin D Augustijn, Daan J Touw, Maro H Sandel, Rosalinde Masereeuw, Frans G M Russel

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e49524 (2012)

Drug-induced liver injury (DILI) is the leading cause of acute liver failure. Currently, no adequate predictive biomarkers for DILI are available. This study describes a translational approach using proteomic profiling for the identification of urina

Externí odkaz: https://doaj.org/article/e72eb2e6d83c4354b2efc7eb581a84fb

Mass spectrometry analysis of hepcidin peptides in experimental mouse models.

Autor: Harold Tjalsma, Coby M M Laarakkers, Rachel P L van Swelm, Milan Theurl, Igor Theurl, Erwin H Kemna, Yuri E M van der Burgt, Hanka Venselaar, Bas E Dutilh, Frans G M Russel, Günter Weiss, Rosalinde Masereeuw, Robert E Fleming, Dorine W Swinkels

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e16762 (2011)

The mouse is a valuable model for unravelling the role of hepcidin in iron homeostasis, however, such studies still report hepcidin mRNA levels as a surrogate marker for bioactive hepcidin in its pivotal function to block ferroportin-mediated iron tr

Externí odkaz: https://doaj.org/article/3ed65de1b8834ba2bf4efc8df56a6788

Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4)

Autor: Jochem Louisse, Luca Dellafiora, Jeroen J. M. W. van den Heuvel, Deborah Rijkers, Liz Leenders, Jean-Lou C. M. Dorne, Ans Punt, Frans G. M. Russel, Jan B. Koenderink

Publikováno v: Archives of Toxicology, 97, 3, pp. 685-696
Archives of Toxicology 97 (2023) 3
Archives of Toxicology, 97(3), 685-696
Archives of Toxicology, 97, 685-696

Contains fulltext : 291310.pdf (Publisher’s version ) (Open Access) Poly- and perfluoroalkyl substances (PFASs) are omnipresent in the environment and have been shown to accumulate in humans. Most PFASs are not biotransformed in animals and humans,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a27e391e6bed55ba30277471e5341f
https://hdl.handle.net/2066/291310