Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Frans De Cock"'
Publikováno v:
Blood. 96:1425-1432
Site directed mutagenesis (350 variants) of recombinant staphylokinase (SakSTAR), a potent fibrin-selective thrombolytic agent, was undertaken in order to reduce its antigenicity while maintaining its potency. Variants with K35A, (ie, Lys[K] in posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99bfc78b6c80e03a4719355b50167f29
https://doi.org/10.1182/blood.v96.4.1425.h8001425_1425_1432
https://doi.org/10.1182/blood.v96.4.1425.h8001425_1425_1432
Publikováno v:
Journal of Biological Chemistry. 270:8397-8400
Induction of an immune response is strongly dependent on the phylogenetic distance between antigen and recipient. In general, antibodies will not be raised against self-antigens nor against highly conserved domains. In the present study we describe t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8202740fe643a2b5fbde34b2568e8ffa
https://doi.org/10.1074/jbc.270.15.8397
https://doi.org/10.1074/jbc.270.15.8397
Autor:
H.R. Lijnen, Desire Collen, Yves Laroche, Yannick Georges Jozef Gansemans, Els Brouwers, Paul Holvoet, Marc Lauwereys, Berthe Van Hoef, Frans De Cock
Publikováno v:
European Journal of Biochemistry. 210:945-952
K12G0S32 is a 57-kDa recombinant single-chain chimeric plasminogen activator consisting of scFv-K12Go, a single-chain variable-region antigen-binding fragment (Fv) of the monoclonal antibody MA-15C5, which is specific for fragment D-dimer of human cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8537995a1b06738c46390b0474a8a9c4
https://doi.org/10.1111/j.1432-1033.1992.tb17499.x
https://doi.org/10.1111/j.1432-1033.1992.tb17499.x
Publikováno v:
European journal of biochemistry. 224(2)
Binding parameters [association-rate (kass and dissociation-rate (kdiss constants, and affinity constants (KA=kass/kdiss)] for the interaction between urokinase-type plasminogen activator (u-PA) and its substrate plasminogen, its inhibitor plasminoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdaa0108f5ef354c42de6fe35c3d05a
https://pubmed.ncbi.nlm.nih.gov/7925373
https://pubmed.ncbi.nlm.nih.gov/7925373
Publikováno v:
European journal of biochemistry. 224(1)
Binding parameters [association (ka) and dissociation (kd) rate constants, and affinity constants (Ka = ka/kd)] for the interaction between recombinant staphylokinase (SakSTAR) and plasmin(ogen) were determined by real-time biospecific interaction an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7b60678f8c18c2e84b11c1b28e8ba1
https://pubmed.ncbi.nlm.nih.gov/8076635
https://pubmed.ncbi.nlm.nih.gov/8076635
Publikováno v:
European Journal of Biochemistry. 100:125-132
Streptokinase reacts very rapidly with human plasmin (rate constant 5.4 S 10(7) M-1 s-1) forming a 1:1 stoichiometric complex which has a dissociation constant of 5 X 10(-11) M. This plasmin-streptokinase complex is 10(5) times less reactive towards
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c580898745ba90a92444bbe9b42a39b
https://doi.org/10.1111/j.1432-1033.1979.tb02040.x
https://doi.org/10.1111/j.1432-1033.1979.tb02040.x
Autor:
Desire Collen, Frans De Cock
Publikováno v:
Biochimica et biophysica acta. 525(1)
Human thrombin·antithrombin III and plasmin·antiplasmin, two enzyme·inhibitor complexes composed of four different molecules, contain antigenic structures not present in the parent molecules, which can be directly quantitated in plasma with the us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67857aa7151a15a1a4cb475fe9b2e571
https://pubmed.ncbi.nlm.nih.gov/150860
https://pubmed.ncbi.nlm.nih.gov/150860
Publikováno v:
European journal of biochemistry. 185(1)
Equimolar mixtures of recombinant single chain urokinase-type plasminogen activator (rscu-PA) and a murine monoclonal antibody (MA-15C5) directed against fragment-D dimer of human cross-linked fibrin were conjugated, using the cross-linking agent N-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f9731bb54e2e1661ea14b8738984bd
https://pubmed.ncbi.nlm.nih.gov/2530085
https://pubmed.ncbi.nlm.nih.gov/2530085