Inhibition of cytosine 5-hydroxymethylation during progression of cancer precursor lesions in the uterine cervix.

Autor: Jobran M Moshi, Monique Ummelen, Frank Smedts, Frans C S Ramaekers, Anton H N Hopman

Publikováno v: PLoS ONE, Vol 19, Iss 4, p e0297008 (2024)

Methylation and hydroxymethylation of cytosine moieties in CpG islands of specific genes are epigenetic processes shown to be involved in the development of cervical (pre)neoplastic lesions. We studied global (hydroxy)methylation during the subsequen

Externí odkaz: https://doaj.org/article/e0f64a838b884ead8dc65e263fb9329a

The Proliferation Index of Erythroid Cells Predicts the Development of Transfusion-dependence in Myelodysplastic Syndrome Patients With Mildly Reduced Hemoglobin Levels at Initial Diagnosis

Autor: Stefan G. C. Mestrum, Norbert C. J. de Wit, Eline M. P. Cremers, Roosmarie J. M. Drent, Frans C. S. Ramaekers, Anton H. N. Hopman, Math P. G. Leers

Publikováno v: HemaSphere, Vol 6, Iss 12, p e804 (2022)

Externí odkaz: https://doaj.org/article/b9e57974a5ba4b56be736fd375b52052

SOX2 expression in the pathogenesis of premalignant lesions of the uterine cervix: its histo-topographical distribution distinguishes between low- and high-grade CIN

Autor: Jobran M. Moshi, Monique Ummelen, Jos L. V. Broers, Frank Smedts, Koen K. Van de Vijver, Jack P. M. Cleutjens, Rogier J. N. T. M. Litjens, Frans C. S. Ramaekers, Anton H. N. Hopman

Publikováno v: Histochemistry and Cell Biology, 158(6), 545-559. Springer Verlag

SOX2 expression in high-grade cervical intraepithelial neoplasia (CIN3) and cervical squamous cell carcinoma is increased compared to that in the normal cervical epithelium. However, data on the expression and histological distribution of SOX2 in squ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57637b121a25e39f87cc0a6672d45ba
https://doi.org/10.1007/s00418-022-02145-6

Evaluation Criteria for Chromosome Instability Detection by FISH to Predict Malignant Progression in Premalignant Glottic Laryngeal Lesions

Autor: Verona E. Bergshoeff, Maschenka C. A. Balkenhol, Annick Haesevoets, Andrea Ruland, Michelene N. Chenault, Rik C. Nelissen, Carine J. Peutz, Ruud Clarijs, Jeroen A. W. M. Van der Laak, Robert P. Takes, Michiel W. Van den Brekel, Marie-Louise F. Van Velthuysen, Frans C. S. Ramaekers, Bernd Kremer, Ernst-Jan M. Speel

Publikováno v: Cancers, 14(13):3260. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 14
Cancers; Volume 14; Issue 13; Pages: 3260
Cancers, 14, 13

BACKGROUND: The definition of objective, clinically applicable evaluation criteria for FISH 1c/7c in laryngeal precursor lesions for the detection of chromosome instability (CI). Copy Number Variations (CNV) for chromosomes 1 and 7 reflect the genera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c420d33fa270c4d6ed0f527f830449ca
https://cris.maastrichtuniversity.nl/en/publications/4b7ea431-de81-4f69-b196-11e252187297

Switches of SOX17 and SOX2 expression in the development of squamous metaplasia and squamous intraepithelial lesions of the uterine cervix

Autor: Leendert H. J. Looijenga, Monique Ummelen, Anton N. H. Hopman, Kim A.D. Wouters, Jobran M. Moshi, Imke Demers, Manon van Engeland, Klaas J. Hoogduin, Mieke Henfling, Frans C. S. Ramaekers, Hans Stoop

Publikováno v: Cancer Medicine, Vol 9, Iss 17, Pp 6330-6343 (2020)
Cancer Medicine
Cancer Medicine, 9(17), 6330-6343. Wiley
Cancer Medicine, 9(17), 6330-6343. John Wiley & Sons Ltd.

Aims The dynamics and topographical distribution of SOX17 and SOX2 expression was studied in the transformation zone (TZ) of the uterine cervix. This TZ is a dynamic area where switches from glandular into squamous epithelium can be recognized, new s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294ce1e481d3fcaa2546b2978d3714b2
https://doaj.org/article/48b7637d65e54d66b12f87f63287acfd