Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Frans Baculi"'
Autor:
Gregory D Ferguson, Mercedes Delgado, Veronique Plantevin-Krenitsky, Kristen Jensen-Pergakes, R J Bates, Sanaa Torres, Maria Celeridad, Heather Brown, Kelven Burnett, Lisa Nadolny, Lida Tehrani, Garrick Packard, Barbra Pagarigan, Jason Haelewyn, Trish Nguyen, Li Xu, Yang Tang, Matthew Hickman, Frans Baculi, Steven Pierce, Keiji Miyazawa, Pilgrim Jackson, Philip Chamberlain, Laurie LeBrun, Weilin Xie, Brydon Bennett, Kate Blease
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0145705 (2016)
Autoantibodies and the immunoreceptors to which they bind can contribute to the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA). Spleen Tyrosine Kinase (Syk) is a non-receptor tyrosine kinase with a central role in immunorecepto
Externí odkaz:
https://doaj.org/article/500fb09ba236468db438ca0053bf54d2
Autor:
Courtney G. Havens, Correa Matthew D, Rama K. Narla, Frans Baculi, Kercher Timothy S, Thomas O. Daniel, Roy L. Harris, Brian E. Cathers, Matt Alexander, Mehran F. Moghaddam, Grant Virginia Heather Sharron, Veronique Plantevin, James Carmichael, Katalin Ebinger, Antonia Lopez-Girona, Gody Khambatta, Derek Mendy, Lawrence G Hamann, Joshua Hansen, Katerina Leftheris, Brandon Wade Whitefield, Joseph Piccotti, Nagy Mark A, Rupert Vessey, Yang Tang, Laurie LeBrun, Jim Leisten, Dehua Huang
Publikováno v:
Journal of Medicinal Chemistry. 63:6648-6676
Many patients with multiple myeloma (MM) initially respond to treatment with modern combination regimens including immunomodulatory agents (lenalidomide and pomalidomide) and proteasome inhibitors. However, some patients lack an initial response to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7c02cb54b83623d7f5d29645738bcd
https://doi.org/10.1021/acs.jmedchem.9b01928
https://doi.org/10.1021/acs.jmedchem.9b01928
Autor:
Yoshitaka Satoh, Gilles Carmel, Frans Baculi, Peter H. Schafer, Laurie LeBrun, Matt Hickman, Thomas O. Daniel, Brian E. Cathers, James Carmichael, Godrej Khambatta, Hon-Wah Man, Mary E Matyskiela, Philip P Chamberlain, Weihong Zhang, Mariko Riley, George W. Muller, Barbra Pagarigan, Gang Lu, Chin-Chun Lu
Publikováno v:
Journal of Medicinal Chemistry. 61:535-542
The drugs lenalidomide and pomalidomide bind to the protein cereblon, directing the CRL4-CRBN E3 ligase toward the transcription factors Ikaros and Aiolos to cause their ubiquitination and degradation. Here we describe CC-220 (compound 6), a cereblon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3ec7b8486c677242241f929022984b
https://doi.org/10.1021/acs.jmedchem.6b01921
https://doi.org/10.1021/acs.jmedchem.6b01921
Autor:
Kevin Ronald Condroski, Matt Hickman, Wei Liu, Laurie LeBrun, Gilles Carmel, Joshua Hansen, Gang Lu, Afshin Mahmoudi, Frans Baculi, Correa Matthew D, Tim Crea, Hon-Wah Man, George W. Muller, Chin-Chun Lu, Alexander L. Ruchelman, Fan Vocanson, Weihong Zhang
Publikováno v:
Journal of Medicinal Chemistry. 61:492-503
We previously disclosed the identification of cereblon modulator 3 (CC-885), with potent antitumor activity mediated through the degradation of GSPT1. We describe herein the structure–activity relationships for analogs of 3 with exploration of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82b447b68c060eec6fd08bffe825f2a7
https://doi.org/10.1021/acs.jmedchem.6b01911
https://doi.org/10.1021/acs.jmedchem.6b01911
Autor:
Joshua D, Hansen, Kevin, Condroski, Matthew, Correa, George, Muller, Hon-Wah, Man, Alexander, Ruchelman, Weihong, Zhang, Fan, Vocanson, Tim, Crea, Wei, Liu, Gang, Lu, Frans, Baculi, Laurie, LeBrun, Afshin, Mahmoudi, Gilles, Carmel, Matt, Hickman, Chin-Chun, Lu
Publikováno v:
Journal of medicinal chemistry. 61(2)
We previously disclosed the identification of cereblon modulator 3 (CC-885), with potent antitumor activity mediated through the degradation of GSPT1. We describe herein the structure-activity relationships for analogs of 3 with exploration of the st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f8916d455404142030cbeb1a6662660c
https://pubmed.ncbi.nlm.nih.gov/28358507
https://pubmed.ncbi.nlm.nih.gov/28358507
Autor:
Gregory D. Ferguson, Frans Baculi, Kristen Jensen-Pergakes, Maria Celeridad, Steven Pierce, Barbra Pagarigan, Garrick Packard, Matt Hickman, Brydon L. Bennett, Yang Tang, Li Xu, Veronique Plantevin-Krenitsky, Sanaa Torres, Lisa Nadolny, Lida Tehrani, R. J. Bates, Trish Nguyen, Jason Haelewyn, Kelven Burnett, Laurie LeBrun, Philip P Chamberlain, Weilin Xie, Kate Blease, Keiji Miyazawa, Mercedes Delgado, Pilgrim Jackson, Heather Brown
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 1, p e0145705 (2016)
PLoS ONE, Vol 11, Iss 1, p e0145705 (2016)
Autoantibodies and the immunoreceptors to which they bind can contribute to the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA). Spleen Tyrosine Kinase (Syk) is a non-receptor tyrosine kinase with a central role in immunorecepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735eeb780f87c758a3b5c102f2711d9a
https://pubmed.ncbi.nlm.nih.gov/26756335
https://pubmed.ncbi.nlm.nih.gov/26756335
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1637-1642
Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases. The molecular modelings of these compounds indicate the preferred binding of the P2′ site of the enzymes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9e856d57f63224f4434f8791bb8bd96
https://doi.org/10.1016/0960-894x(95)00282-x
https://doi.org/10.1016/0960-894x(95)00282-x