Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Frans B.L. Hogervorst"'
Autor:
Jos Jonkers, Frans B.L. Hogervorst, Jost Seibler, Ellen Wientjens, Mark Pieterse, Pramudita Prasetyanti, Christiaan N. Klijn, Rinske Drost, Ingrid van der Heijden, Hanneke van der Gulden, Peter Bouwman
Supplementary Methods - PDF 55K, A detailed protocol for the classification of BRCA1 sequence variants using R26CreERT2/RMCE;Brca1SCo/{delta} ES cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068d5af15587535ab78cd5d5eaacd641
https://doi.org/10.1158/2159-8290.22528938
https://doi.org/10.1158/2159-8290.22528938
Autor:
Jos Jonkers, Frans B.L. Hogervorst, Jost Seibler, Ellen Wientjens, Mark Pieterse, Pramudita Prasetyanti, Christiaan N. Klijn, Rinske Drost, Ingrid van der Heijden, Hanneke van der Gulden, Peter Bouwman
Supplementary Tables 1-4 - PDF 99K, Information on BRCA1 mutants used to validate the functional complementation assays (Table S1), BRCA1 VUS showing low protein levels (Table S2), the results of all proliferation and cisplatin sensitivity assays (Ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e662a2da6366b4ce4366ef39ae5213c2
https://doi.org/10.1158/2159-8290.22528935.v1
https://doi.org/10.1158/2159-8290.22528935.v1
Autor:
Jos Jonkers, Frans B.L. Hogervorst, Jost Seibler, Ellen Wientjens, Mark Pieterse, Pramudita Prasetyanti, Christiaan N. Klijn, Rinske Drost, Ingrid van der Heijden, Hanneke van der Gulden, Peter Bouwman
Supplementary Figures 1-4 - PDF 213K, This file contains additional data on the generation of R26CreERT2/RMCE;Brca1SCo/{delta} ES cells and analysis of Rosa26 targeted human BRCA1 cDNA expression (Fig. S1), analysis of BRCA1 VUS protein and mRNA expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14fd47eaa865c087f9c6b724991ad2ab
https://doi.org/10.1158/2159-8290.22528941.v1
https://doi.org/10.1158/2159-8290.22528941.v1
Autor:
Petra M. Nederlof, Frans B.L. Hogervorst, Jelle Wesseling, Lizet E. van der Kolk, Gabe S. Sonke, Lennart Mulder, Caroline E. Scheerman, Rashmie D. Debipersad, Esther H. Lips
This file includes the legends for supplementary figure 1 and supplementary tables 1 and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c45c195a008484280f80c3fb44def4c
https://doi.org/10.1158/1078-0432.22466966
https://doi.org/10.1158/1078-0432.22466966
Autor:
Petra M. Nederlof, Frans B.L. Hogervorst, Jelle Wesseling, Lizet E. van der Kolk, Gabe S. Sonke, Lennart Mulder, Caroline E. Scheerman, Rashmie D. Debipersad, Esther H. Lips
This file shows the significant regions (highlighted in supplementary figure 1) for the comparison B1mutER+ versus SporER+. Subsequently the weighted average frequency in B1mutER+, in SporER+ and the difference between both groups is shown. The last
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109bd2b2cf61bf93971b935a587b2cb0
https://doi.org/10.1158/1078-0432.22466957
https://doi.org/10.1158/1078-0432.22466957
Autor:
Jacques Simard, Kenneth Offit, Georgia Chenevix-Trench, Douglas F. Easton, Phuong L. Mai, Mark H. Greene, Paolo Radice, Liliana Varesco, Giuseppe Giannini, Alessandra Viel, Loris Bernard, Monica Barile, Daniela Zaffaroni, Bernard Peissel, Siranoush Manoukian, Paolo Peterlongo, V. Shane Pankratz, Zachary Fredericksen, Noralane M. Lindor, Yuan Chun Ding, Susan L. Neuhausen, Amanda B. Spurdle, Marc D. Tischkowitz, Heli Nevanlinna, Taru A. Muranen, Miguel de la Hoya, Trinidad Caldes, Wolfram Heinritz, Britta Fiebig, Karin Kast, Christian Sutter, Andrea Gehrig, Helmut Deissler, Raymonda Varon-Mateeva, Dorothea Gadzicki, Sabine Preisler-Adams, Dieter Niederacher, Simone Heidemann, Norbert Arnold, Nina Ditsch, Alfons Meindl, Christoph Engel, Barbara Wappenschmidt, Rita K. Schmutzler, Ava Kwong, Orland Diez, Cecelia M. Dorfling, Elizabeth J. van Rensburg, Mary S. Beattie, Patricia A. Ganz, Soo Hwang Teo, Edith Olah, Christine S. Walsh, Beth Y. Karlan, Kunle O. Odunsi, Paul P.D. Pharoah, Simon A. Gayther, Joan Brunet, Lidia Feliubadalo, Ignacio Blanco, Conxi Lazaro, Ramunas Janavicius, Claudine Isaacs, Evgeny N. Imyanitov, Simona Agata, Marco Montagna, Amanda Ewart-Toland, Katie Wakeley, John Boggess, Wendy S. Rubinstein, Jack Basil, Kelly Phillips, Marion Piedmonte, Mark E. Robson, Kara Sarrel, Sohela Shah, Joseph Vijai, Aðalgeir Arason, Finn C. Nielsen, Thomas V.O. Hansen, Anneliese Fink-Retter, Muy-Kheng M. Tea, Christine Rappaport, Christian F. Singer, David E. Goldgar, John L. Hopper, Melissa C. Southey, Alexander Miron, Esther M. John, Wendy K. Chung, MaryBeth Terry, Mary B. Daly, Saundra S. Buys, Carrie L. Snyder, Henry T. Lynch, Linda Akloul, Capucine Delnatte, Isabelle Coupier, Pascal Pujol, Olivier Caron, Brigitte Bressac-de Paillerets, Nadia Boutry-Kryza, Mélanie Léoné, Sylvie Mazoyer, François Cornelis, Laurent Castera, Marion Fassy-Colcombet, Dominique Stoppa-Lyonnet, Andrew K. Godwin, Betsy Bove, Lucy E. Side, M. John Kennedy, Mary E. Porteous, Lisa Walker, Patrick J. Morrison, Shirley V. Hodgson, Fiona Douglas, Carole Brewer, Joan Paterson, Jackie Cook, Trevor Cole, Diana M. Eccles, Rosemarie Davidson, Julian Adlard, Rosalind A. Eeles, Chris Jacobs, D. Gareth Evans, Elena Fineberg, Radka Platte, Steve D. Ellis, Debra Frost, Susan Peock, Margreet G.E.M. Ausems, Rogier A. Oldenburg, Maartje J. Hooning, Marleen Kets, Marinus J. Blok, Juul Wijnen, Hanne E.J. Meijers-Heijboer, Flora E. van Leeuwen, Theo A. van Os, Frans B.L. Hogervorst, Ute Hamann, Javier Benitez, María Isabel Tejada, Mercedes Durán, Ana Osorio, Bohdan Górski, Cezary Cybulski, Jacek Gronwald, Tomasz Byrski, Tomasz Huzarski, Elżbieta Złowocka, Katarzyna Durda, Katarzyna Jaworska, Jan Lubinski, Ania Jakubowska, Susan M. Domchek, Timothy R. Rebbeck, Katherine L. Nathanson, Per Karlsson, Hans Ehrencrona, Maria Soller, Niklas Loman, Gisela Barbany-Bustinza, Anna von Wachenfeldt, Maria A. Caligo, Torben A. Kruse, Anne-Bine Skytte, Uffe Birk Jensen, Anne-Marie Gerdes, Mads Thomassen, Anna Marie Mulligan, Hilmi Ozcelik, Irene L. Andrulis, Olga M. Sinilnikova, Sue Healey, Andrew Lee, Daniel Barrowdale, Lesley McGuffog, Tomas Kirchhoff, Xianshu Wang, Xiaoqing Chen, Jonathan Beesley, Penny Soucy, Karoline B. Kuchenbaecker, Susan J. Ramus, Antonis C. Antoniou, Mia M. Gaudet, Fergus J. Couch
PDF file - 90K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f8d06ff43e4caf36f48984c98f91d1
https://doi.org/10.1158/1055-9965.22436115.v1
https://doi.org/10.1158/1055-9965.22436115.v1
Autor:
Jacques Simard, Kenneth Offit, Georgia Chenevix-Trench, Douglas F. Easton, Phuong L. Mai, Mark H. Greene, Paolo Radice, Liliana Varesco, Giuseppe Giannini, Alessandra Viel, Loris Bernard, Monica Barile, Daniela Zaffaroni, Bernard Peissel, Siranoush Manoukian, Paolo Peterlongo, V. Shane Pankratz, Zachary Fredericksen, Noralane M. Lindor, Yuan Chun Ding, Susan L. Neuhausen, Amanda B. Spurdle, Marc D. Tischkowitz, Heli Nevanlinna, Taru A. Muranen, Miguel de la Hoya, Trinidad Caldes, Wolfram Heinritz, Britta Fiebig, Karin Kast, Christian Sutter, Andrea Gehrig, Helmut Deissler, Raymonda Varon-Mateeva, Dorothea Gadzicki, Sabine Preisler-Adams, Dieter Niederacher, Simone Heidemann, Norbert Arnold, Nina Ditsch, Alfons Meindl, Christoph Engel, Barbara Wappenschmidt, Rita K. Schmutzler, Ava Kwong, Orland Diez, Cecelia M. Dorfling, Elizabeth J. van Rensburg, Mary S. Beattie, Patricia A. Ganz, Soo Hwang Teo, Edith Olah, Christine S. Walsh, Beth Y. Karlan, Kunle O. Odunsi, Paul P.D. Pharoah, Simon A. Gayther, Joan Brunet, Lidia Feliubadalo, Ignacio Blanco, Conxi Lazaro, Ramunas Janavicius, Claudine Isaacs, Evgeny N. Imyanitov, Simona Agata, Marco Montagna, Amanda Ewart-Toland, Katie Wakeley, John Boggess, Wendy S. Rubinstein, Jack Basil, Kelly Phillips, Marion Piedmonte, Mark E. Robson, Kara Sarrel, Sohela Shah, Joseph Vijai, Aðalgeir Arason, Finn C. Nielsen, Thomas V.O. Hansen, Anneliese Fink-Retter, Muy-Kheng M. Tea, Christine Rappaport, Christian F. Singer, David E. Goldgar, John L. Hopper, Melissa C. Southey, Alexander Miron, Esther M. John, Wendy K. Chung, MaryBeth Terry, Mary B. Daly, Saundra S. Buys, Carrie L. Snyder, Henry T. Lynch, Linda Akloul, Capucine Delnatte, Isabelle Coupier, Pascal Pujol, Olivier Caron, Brigitte Bressac-de Paillerets, Nadia Boutry-Kryza, Mélanie Léoné, Sylvie Mazoyer, François Cornelis, Laurent Castera, Marion Fassy-Colcombet, Dominique Stoppa-Lyonnet, Andrew K. Godwin, Betsy Bove, Lucy E. Side, M. John Kennedy, Mary E. Porteous, Lisa Walker, Patrick J. Morrison, Shirley V. Hodgson, Fiona Douglas, Carole Brewer, Joan Paterson, Jackie Cook, Trevor Cole, Diana M. Eccles, Rosemarie Davidson, Julian Adlard, Rosalind A. Eeles, Chris Jacobs, D. Gareth Evans, Elena Fineberg, Radka Platte, Steve D. Ellis, Debra Frost, Susan Peock, Margreet G.E.M. Ausems, Rogier A. Oldenburg, Maartje J. Hooning, Marleen Kets, Marinus J. Blok, Juul Wijnen, Hanne E.J. Meijers-Heijboer, Flora E. van Leeuwen, Theo A. van Os, Frans B.L. Hogervorst, Ute Hamann, Javier Benitez, María Isabel Tejada, Mercedes Durán, Ana Osorio, Bohdan Górski, Cezary Cybulski, Jacek Gronwald, Tomasz Byrski, Tomasz Huzarski, Elżbieta Złowocka, Katarzyna Durda, Katarzyna Jaworska, Jan Lubinski, Ania Jakubowska, Susan M. Domchek, Timothy R. Rebbeck, Katherine L. Nathanson, Per Karlsson, Hans Ehrencrona, Maria Soller, Niklas Loman, Gisela Barbany-Bustinza, Anna von Wachenfeldt, Maria A. Caligo, Torben A. Kruse, Anne-Bine Skytte, Uffe Birk Jensen, Anne-Marie Gerdes, Mads Thomassen, Anna Marie Mulligan, Hilmi Ozcelik, Irene L. Andrulis, Olga M. Sinilnikova, Sue Healey, Andrew Lee, Daniel Barrowdale, Lesley McGuffog, Tomas Kirchhoff, Xianshu Wang, Xiaoqing Chen, Jonathan Beesley, Penny Soucy, Karoline B. Kuchenbaecker, Susan J. Ramus, Antonis C. Antoniou, Mia M. Gaudet, Fergus J. Couch
Background: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively. We explored associations with ovarian cancer and with brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e50c0b9f0e302f4bf4a4427c659460d
https://doi.org/10.1158/1055-9965.c.6515235
https://doi.org/10.1158/1055-9965.c.6515235
Autor:
Petra M. Nederlof, Frans B.L. Hogervorst, Jelle Wesseling, Lizet E. van der Kolk, Gabe S. Sonke, Lennart Mulder, Caroline E. Scheerman, Rashmie D. Debipersad, Esther H. Lips
This figure shows pairwise comparisons between the BRCA2-mutated ER+ tumors and the sporadic ER+ tumors (upper panel) and the BRCA1-mutated ER+tumors and the sporadic ER+ tumors (lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457a7f4b43cb3ca722731219da64a8c4
https://doi.org/10.1158/1078-0432.22466963
https://doi.org/10.1158/1078-0432.22466963
Autor:
Petra M. Nederlof, Frans B.L. Hogervorst, Jelle Wesseling, Lizet E. van der Kolk, Gabe S. Sonke, Lennart Mulder, Caroline E. Scheerman, Rashmie D. Debipersad, Esther H. Lips
This file shows the significant regions (highlighted in supplementary figure 1) for the comparison B2mutER+ versus SporER+. Subsequently the weighted average frequency in B2mutER+, in SporER+ and the difference between both groups is shown. The last
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188fcc2c697a68d9ef33e61a441ecf2b
https://doi.org/10.1158/1078-0432.22466960
https://doi.org/10.1158/1078-0432.22466960
Autor:
Fred H. Menko, Kim Monkhorst, Frans B.L. Hogervorst, Efraim H. Rosenberg, Muriel A. Adank, Mariëlle W.G. Ruijs, Eveline M.A. Bleiker, Gabe S. Sonke, Nicola S. Russell, Hester S.A. Oldenburg, Lizet E. van der Kolk
Publikováno v:
Critical Reviews in Oncology/Hematology. 176:103642
Current methods of next generation sequencing may simultaneously detect multiple germline breast cancer susceptibility variants. However, it is a challenge to maximize the clinical benefit of genetic analysis for patients and family members while min