Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Frans Awouters"'
Autor:
Bryan L. Roth
Publikováno v:
Schizophrenia Research. 24:369-369
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc3b683c066abc94889a69b356d946a4
https://doi.org/10.1016/s0920-9964(97)85209-7
https://doi.org/10.1016/s0920-9964(97)85209-7
Autor:
Frans Awouters, Paul J. Lewi
Publikováno v:
Arzneimittelforschung. 57:625-632
The authors describe 40 years of antipsychotic drug research with Dr. Paul Janssen, which they have witnessed for a large part from first hand experience. The article describes the start of the Janssen Research and its early successes with antispasmo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ab34dc85092ceed20f655a575d68e3
https://doi.org/10.1055/s-0031-1296660
https://doi.org/10.1055/s-0031-1296660
Autor:
Frans Awouters, Anton Megens
Publikováno v:
Drug Development Research. 33:399-412
9-Hydroxyrisperidone (9OH-risperidone) is the major metabolite of the new antipsychotic risperidone. 9OH-risperidone was compared with risperidone in a series of pharmacological tests in rats; ritanserin and haloperidol were included as reference com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cc06a183a6e1560ac0c26aebe52ea01
https://doi.org/10.1002/ddr.430330403
https://doi.org/10.1002/ddr.430330403
Autor:
Anton Megens, J. E. Leysen, Theo F. Meert, Carlos J. E. Niemegeers, Christine Dugovic, Alain Schotte, Frans Awouters
Publikováno v:
Psychopharmacology. 114:9-23
This review reports on the pharmacodynamics of the new antipsychotic risperidone. The primary action of risperidone is serotonin 5-HT2 receptor blockade as shown by displacement of radioligand binding (Ki: 0.16 nM), activity on isolated tissues (EC50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949e82103102d1878b482b5339e85be3
https://doi.org/10.1007/bf02245439
https://doi.org/10.1007/bf02245439
Autor:
Frans Awouters, J. A. J. Schuurkes, Paul A. J. Janssen, Anton Megens, M. Verlinden, Carlos J. E. Niemegeers
Publikováno v:
Digestive Diseases and Sciences. 38:977-995
In castor oil challenged rats, low doses of loperamide inhibit diarrhea and normalize intestinal propulsion. Unlike other opioids, loperamide is devoid of central opiate-like effects, including blockade of intestinal propulsion, up to the highest sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597d98529899a261ccc6c242aaad7371
https://doi.org/10.1007/bf01295711
https://doi.org/10.1007/bf01295711
Publikováno v:
Drug Development Research. 26:129-145
Motor activity effects of haloperidol, risperidone, and ocaperidone were studied in rats challenged with amphetamine. At a low dose of amphetamine, the compounds were about equipotent in reducing amphetamine-induced hyperactivity to normal values (lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fea8b048a1b3a5d31d00387d821e089a
https://doi.org/10.1002/ddr.430260203
https://doi.org/10.1002/ddr.430260203
Publikováno v:
The international journal of neuropsychopharmacology. 2(3)
In brain capillary endothelium and catecholaminergic terminals a single decarboxylation step effected by aromatic amino-acid decarboxylase converts phenylalanine to phenylethylamine, at a rate comparable to that of the central synthesis of dopamine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f49b3a668f55fc1a70334729b5e73d9
https://pubmed.ncbi.nlm.nih.gov/11281991
https://pubmed.ncbi.nlm.nih.gov/11281991
Publikováno v:
Journal of pain and symptom management. 15(4)
Clinical studies report a low incidence of intestinal side effects with transdermally administered fentanyl (TTS-fentanyl) in comparison with oral morphine. To support these clinical data, analgesic and intestinal effects of both opioids were compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86454efa0bcfa2c3592505baa86fad5a
https://pubmed.ncbi.nlm.nih.gov/9601161
https://pubmed.ncbi.nlm.nih.gov/9601161
Publikováno v:
Agents and actions. 35(1-2)
Levocabastine, selected from a series of cyclohexylpiperidine derivatives protects rats from compound 48/80-induced anaphylactic shock for at least 16 h at the oral dose of 0.0015 mg/kg. At the same dose histamine skin reactions and at slightly highe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822aebae205a4b5ef9eb174c94c8be22
https://pubmed.ncbi.nlm.nih.gov/1354927
https://pubmed.ncbi.nlm.nih.gov/1354927