Genome-Wide Analysis of Gene and Protein Expression of Dysplastic Naevus Cells

Autor: Linda Gao, Frans A. van Nieuwpoort, Jacoba J. Out-Luiting, Paul J. Hensbergen, Femke A. de Snoo, Wilma Bergman, Remco van Doorn, Nelleke A. Gruis

Publikováno v: Journal of Skin Cancer, Vol 2012 (2012)

Cutaneous melanoma, a type of skin tumor originating from melanocytes, often develops from premalignant naevoid lesions via a gradual transformation process driven by an accumulation of (epi)genetic lesions. These dysplastic naevi display altered mor

Externí odkaz: https://doaj.org/article/e2bc4ce6cc3a4aa389c91b836c3292e7

Genome-wide association study identifies three new melanoma susceptibility loci

Autor: Eitan Friedman, Shenying Fang, Jeffrey E. Lee, Esther Azizi, Marie-Françoise Avril, Douglas F. Easton, Julia A. Newton Bishop, Julie Lang, Elizabeth M. Gillanders, Juliette Randerson-Moor, Jan Lubinski, D. Timothy Bishop, Bruce K. Armstrong, Donato Calista, Florence Demenais, Joan Anton Puig-Butille, Anne E. Cust, Tadeusz Dȩbniak, Graham G. Giles, Grant W. Montgomery, Lorenza Pastorino, David C. Whiteman, Kevin M. Brown, Nicholas G. Martin, Diana Zelenika, Maria Teresa Landi, Jennifer H. Barrett, Veronica Höiom, Pilar Galan, Qingyi Wei, Johan Hansson, Lars A. Akslen, Bert Bakker, Brigitte Bressac-de Paillerets, Josep Malvehy, Rainer Tuominen, Wilma Bergman, Mark M. Iles, Stuart MacGregor, Jiali Han, Rona M. MacKie, Nicholas K. Hayward, Richard F. Kefford, Mark A. Jenkins, Christian Ingvar, Anders Molven, Graham J. Mann, Lisa A. Cannon-Albright, David E. Elder, Göran Jönsson, Joanne F. Aitken, Mark Harland, John L. Hopper, David L. Duffy, Eve Corda, Helen Snowden, Peter A. Kanetsky, Alisa M. Goldstein, Alison M. Dunning, John C. Taylor, Giorgio Landi, Håkan Olsson, Paola Ghiorzo, Nienke van der Stoep, Bart Janssen, Per Arne Andresen, Susana Puig, Nelleke A. Gruis, Marko Hočevar, Frans A. van Nieuwpoort, Srdjan Novaković, G. Mark Lathrop, Patricia Van Belle, Giovanna Bianchi-Scarrà, Christopher I. Amos

Publikováno v: Nature genetics
Nature Genetics, 43(11), 1108-U98
Nature Genetics
Nature Genetics, Nature Publishing Group, 2011, 43 (11), pp.1108-U98. ⟨10.1038/ng.959⟩
Dipòsit Digital de la UB
Universidad de Barcelona

We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709d559a17530681126b93462d532230
http://europepmc.org/articles/PMC3251256

Disturbed melanin synthesis and chronic oxidative stress in dysplastic naevi

Autor: Hans van der Meulen, Petra Cetkovska, Karel Pizinger, Nico P.M. Smit, Frans A. van Nieuwpoort, Stan Pavel, Coby J. Out, Henk K. Koerten

Publikováno v: European Journal of Cancer. 40:1423-1430

Dysplastic naevi (DN) are a known risk factor for malignant melanoma. Their occurrence is closely connected with the degree of skin pigmentation. People with a light complexion are more likely to develop DN than dark-skinned individuals. We examined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619ea329d322fdd16c8970b828c0787e
https://doi.org/10.1016/j.ejca.2003.11.035

Increased risk of cancer other than melanoma in CDKN2A founder mutation (p16-Leiden)-positive melanoma families

Autor: Inge van Leeuwen, Femke A. de Snoo, Rune R. Frants, Wilma Bergman, Martijn H. Breuning, Clasine van der Drift, D. Timothy Bishop, Hans F. A. Vasen, Coby Out-Luiting, Nelleke A. Gruis, Rein Willemze, Frans A. van Nieuwpoort, Jeanet A.C. ter Huurne

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 14(21)

Purpose: We report the largest study to date analyzing the risk of cancers other than melanoma in melanoma families positive for the same CDKN2A mutation. Experimental Design: We studied family members of 22 families positive for the p16-Leiden found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f74e6b67156659b513c875b76b23c19
https://pubmed.ncbi.nlm.nih.gov/18981015

Increased p21-activated kinase-1 expression is associated with invasive potential in uveal melanoma

Autor: Nelleke A. Gruis, Wieke Zuidervaart, Frans A. van Nieuwpoort, Sandra Pavey, Nicholas K. Hayward, Martine J. Jager, Leisl M. Packer

Publikováno v: Melanoma research. 16(4)

Prognosis in patients with uveal melanoma is poor as approximately half of all tumors metastasize and currently there are no effective treatments for disseminated disease. Differences in invasiveness between uveal melanomas could therefore be of majo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dca3e2c3e0b019de05afa9f91ad6837
https://pubmed.ncbi.nlm.nih.gov/16845324