Zobrazeno 1 - 10
of 260
pro vyhledávání: '"Frans A. Kuypers"'
The RoxyScan is a novel measurement of red blood cell deformability under oxidative and shear stress
Autor:
Sandra K. Larkin, Carolina Hernández, Eduard J. van Beers, Richard van Wijk, Frans A. Kuypers
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Exposure to both oxidative and shear stress, a condition that the red blood cell (RBC) continuously experiences in the circulation in vivo can be mimicked in a Couette type viscometer and monitored by ektacytometry. RBCs maintain their defor
Externí odkaz:
https://doaj.org/article/845e236a98da420f9bbef630cef4d920
Autor:
Patrick B. Walter, Leah S. Hohman, Andrew Rokeby, Julian J. Lum, Robert Hagar, Lisa Lavrisha, Augusta Saulys, Frans A. Kuypers, Elliott Vichinsky, Claudia R. Morris
Publikováno v:
Complementary Therapies in Medicine, Vol 70, Iss , Pp 102856- (2022)
Objectives: L-Glutamine was FDA-approved for sickle cell disease (SCD) in 2017, yet the mechanism(s)-of-action are poorly understood. This study investigates the potential activation of autophagy as a previously unexplored mechanism-of-benefit. Desig
Externí odkaz:
https://doaj.org/article/560b1ca54ac24f2ea448737dead2bb32
Autor:
Claudia R. Morris, Frans A. Kuypers, Robert Hagar, Sandra Larkin, Lisa Lavrisha, Augusta Saulys, Elliott P. Vichinsky, Jung H. Suh
Publikováno v:
Complementary Therapies in Medicine, Vol 64, Iss , Pp 102803- (2022)
Objectives: L-Glutamine is FDA-approved for sickle cell disease (SCD), yet the mechanism(s)-of-action are poorly understood. We performed a pharmacokinetics (pK) study to determine the metabolic fate of glutamine supplementation on plasma and erythro
Externí odkaz:
https://doaj.org/article/9bed86b6c7124eceb1325cd9253e7c0e
Publikováno v:
PLoS ONE, Vol 17, Iss 11 (2022)
Anemia is a continuing global public health concern and a priority for international action. The prevalence of anemia is estimated from the hemoglobin (Hb) levels within target populations, yet the procedures for measuring Hb are not standardized and
Externí odkaz:
https://doaj.org/article/82edc419760944c18717dfc0a25a8acb
Autor:
Eric Soupene, Frans A. Kuypers
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1726 (2022)
The transfer of acyl chains to proteins and lipids from acyl-CoA donor molecules is achieved by the actions of diverse enzymes and proteins, including the acyl-CoA binding domain-containing protein ACBD6. N-myristoyl-transferase (NMT) enzymes catalyz
Externí odkaz:
https://doaj.org/article/4c5eaa27eca44f11ad399d1568b7002b
Autor:
Eric Soupene, Frans A. Kuypers
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 624-635 (2019)
Members of the human acyl-CoA binding domain-containing (ACBD) family regulate processes as diverse as viral replication, stem-cell self-renewal, organelle organization, and protein acylation. These functions are defined by nonconserved motifs presen
Externí odkaz:
https://doaj.org/article/561360c8687b4baeaf8fa0e0393987aa
Publikováno v:
PLoS ONE, Vol 16, Iss 6 (2021)
The etiology of necrotizing enterocolitis (NEC) is not known. Alterations in gut microbiome, mucosal barrier function, immune cell activation, and blood flow are characterized events in its development, with stress as a contributing factor. The hormo
Externí odkaz:
https://doaj.org/article/45bd15b67f5245b4b6a8d8f60d0acddb
Autor:
Eric Soupene, Joseph Kao, Daniel H. Cheng, Derek Wang, Alexander L. Greninger, Giselle M. Knudsen, Joseph L. DeRisi, Frans A. Kuypers
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 2, Pp 288-298 (2016)
The covalent attachment of a 14-carbon aliphatic tail on a glycine residue of nascent translated peptide chains is catalyzed in human cells by two N-myristoyltransferase (NMT) enzymes using the rare myristoyl-CoA (C14-CoA) molecule as fatty acid dono
Externí odkaz:
https://doaj.org/article/7ab2d23d8f324592a7996ce773f20e69
Autor:
Eric Soupene, Frans A. Kuypers
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 10, Pp 1961-1971 (2015)
The binding determinants of the human acyl-CoA binding domain-containing protein (ACBD) 6 and its function in lipid renewal of membranes were investigated. ACBD6 binds acyl-CoAs of a chain length of 6 to 20 carbons. The stoichiometry of the associati
Externí odkaz:
https://doaj.org/article/199f4d84a21e4735bdaf4554e4f881bd
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 5, Pp 1103-1112 (2008)
Human acyl-coenzyme A binding domain-containing member 6 (ACBD6) is a modular protein that carries an acyl-CoA binding domain at its N terminus and two ankyrin motifs at its C terminus. ACBD6 binds long-chain acyl-CoAs with a strong preference for un
Externí odkaz:
https://doaj.org/article/6f07a07124454e84ac9e86378f674103