Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Frans A. E. Sollie"'
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 43:282-293
Objective: A novel sulfonamide derivative, S-3304, was discovered as a potent matrix metalloproteinase (MMP) inhibitor. It is a more specific inhibitor to MMP-2 and MMP-9 (in vitro) than to MMP-1, and may therefore lack the musculoskeletal side effec
Autor:
Ch. B. Lugt, P. A. M. Peeters, Polrat Wilairatana, Sornchai Looareesuwan, Frans A. E. Sollie, B. M. Schilizzi, James O. Peggins, B. Oosterhuis, Srivicha Krudsood
Publikováno v:
British Journal of Clinical Pharmacology. 53:492-500
Aims The antimalarial efficacy/pharmacodynamics and pharmacokinetics of intramuscular (i.m.) artemotil in Thai patients with acute uncomplicated falciparum malaria were studied to determine effective dose regimens and to compare these with the standa
Autor:
Sjoerd P. van Marle, Frans A. E. Sollie, Jochen Schmid, Heinz Switek, Aalt Verhagen, Jan H. G. Jonkman, W.J Tamminga, Dietrich Türck, Pierre Peeters, Joachim Stangier
Publikováno v:
The Journal of Clinical Pharmacology. 40:1312-1322
The study was conducted in healthy male volunteers to evaluate the absorption, metabolic pattern, and mode of elimination of telmisartan, a nonpeptide angiotensin II receptor antagonist. [14C]telmisartan was administered orally in solution as a singl
Autor:
Frans A. E. Sollie, B. Oosterhuis, Chung‐An P. F. Su, Jan H. G. Jonkman, Jan J. van Lier, Maarten G. C. Hendriks, Joachim Stangier
Publikováno v:
The Journal of Clinical Pharmacology. 40:1331-1337
The effects of multiple-dose telmisartan on the steady-state pharmacodynamics and pharmacokinetics of warfarin were assessed in 12 healthy young males in an open-label, single-period study conducted over 30 days. Subjects received loading doses of or
The Effect of Telmisartan on the Steady‐State Pharmacokinetics of Digoxin in Healthy Male Volunteers
Autor:
Jan J. van Lier, B. Oosterhuis, Joachim Stangier, Frans A. E. Sollie, Chung‐An P. F. Su, Jan H. G. Jonkman, Maarten G. C. Hendriks
Publikováno v:
The Journal of Clinical Pharmacology. 40:1373-1379
A multiple-dose, open-label, two-period, crossover randomized study was conducted in 12 healthy male volunteers to investigate the effect of multiple-dose telmisartan on the steady-state pharmacokinetics of digoxin. On day 1 of a 7-day medication per
Autor:
John Allanson, Deborah A. Smith, Richard Peck, Nanco R. Hefting, Jan J. van Lier, Emma J. Seaber, Frans A. E. Sollie, Johan Wemer, Jan H. G. Jonkman
Publikováno v:
British Journal of Clinical Pharmacology. 46:433-439
Aims Zolmitriptan (Zomig (formerly 311C90)) is a novel 5-HT1B/1D receptor agonist developed for the acute oral treatment of migraine. A highly sensitive LCMS-MS assay has been developed which allows quantification of plasma concentrations of zolmitri
Publikováno v:
The Journal of Clinical Pharmacology. 36:639-646
An open, randomized, three-period crossover study was conducted to compare the steady-state pharmacokinetics, pharmacodynamics, and tolerability of concomitant administration of BAY x 1005 and theophylline in 12 healthy volunteers. BAY x 1005 (250 mg
Publikováno v:
Clinical pharmacology and therapeutics. 49(3)
During this open, two-period crossover study in eight healthy volunteers, 1200 mg anhydrous theophylline was administered as a two-stage infusion during 24 hours on day 6. During one of the 8-day periods, 300 mg caffeine, t.i.d., was administered ora
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 16:203-228
This investigation developed strategies along which the anticonvulsant effect of oxazepam in the rat could be pharmacokinetically modeled. After determination of the pharmacokinetics of oxazepam, which could be described with a two-compartment model