Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Franklin R Toapanta"'
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0189571 (2018)
We refine and clinically parameterize a mathematical model of the humoral immune response against Shigella, a diarrheal bacteria that infects 80-165 million people and kills an estimated 600,000 people worldwide each year. Using Latin hypercube sampl
Externí odkaz:
https://doaj.org/article/090fd3d1baec42aeabe4e134e4030698
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196367 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0189571.].
Externí odkaz:
https://doaj.org/article/aeaf6d00ec6049d998e4130ecd88972c
Autor:
Nicolas Hegerle, Myeongjin Choi, James Sinclair, Mohammed N Amin, Morgane Ollivault-Shiflett, Brittany Curtis, Rachel S Laufer, Surekha Shridhar, Jerod Brammer, Franklin R Toapanta, Ian Alan Holder, Marcela F Pasetti, Andrew Lees, Sharon M Tennant, Alan S Cross, Raphael Simon
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203143 (2018)
Klebsiella pneumoniae (KP) and Pseudomonas aeruginosa (PA) are important human pathogens that are associated with a range of infection types, including wound and disseminated infections. Treatment has been complicated by rising rates of antimicrobial
Externí odkaz:
https://doaj.org/article/77d21b49b7734efc8c1eea23ff9e702e
Autor:
Franklin R Toapanta, Paula J Bernal, Stephanie Fresnay, Laurence S Magder, Thomas C Darton, Claire Jones, Claire S Waddington, Christoph J Blohmke, Brian Angus, Myron M Levine, Andrew J Pollard, Marcelo B Sztein
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 6, p e0004766 (2016)
A novel human oral challenge model with wild-type Salmonella Typhi (S. Typhi) was recently established by the Oxford Vaccine Group. In this model, 104 CFU of Salmonella resulted in 65% of participants developing typhoid fever (referred here as typhoi
Externí odkaz:
https://doaj.org/article/6662c9eed7494cddb4ea33aa3199b8da
Autor:
Franklin R Toapanta, Paula J Bernal, Stephanie Fresnay, Thomas C Darton, Claire Jones, Claire S Waddington, Christoph J Blohmke, Gordon Dougan, Brian Angus, Myron M Levine, Andrew J Pollard, Marcelo B Sztein
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003837 (2015)
A new human oral challenge model with wild-type Salmonella Typhi (S. Typhi) was recently developed. In this model, ingestion of 104 CFU of Salmonella resulted in 65% of subjects developing typhoid fever (referred here as typhoid diagnosis -TD-) 5-10
Externí odkaz:
https://doaj.org/article/14740c148edc4c82a1fcaf476c8ad912
Autor:
Franklin R. Toapanta, Jingping Hu, Kari Ann Shirey, Paula J. Bernal, Myron M. Levine, Thomas C. Darton, Claire S. Waddington, Andrew J. Pollard, Marcelo B. Sztein
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
An oral Controlled Human Infection Model (CHIM) with wild-type S. Typhi was re-established allowing us to explore the development of immunity. In this model, ~55% of volunteers who received the challenge reached typhoid diagnosis criteria (TD), while
Externí odkaz:
https://doaj.org/article/7f2e05bb0a404438a4c9919701980c1f
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionNon-typhoidal Salmonella (NTS) generally causes self-limiting gastroenteritis. However, older adults (≥65 years) can experience more severe outcomes from NTS infection. We have previously shown that a live attenuated S. Typhimurium vacc
Externí odkaz:
https://doaj.org/article/d083e0f41da24e1b88aa5c44f2b9a9ed
Autor:
Anna M Seekatz, Aruna Panda, David A Rasko, Franklin R Toapanta, Emiley A Eloe-Fadrosh, Abdul Q Khan, Zhenqiu Liu, Steven T Shipley, Louis J Detolla, Marcelo B Sztein, Claire M Fraser
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e64212 (2013)
Little is known about the role of gut microbiota in response to live oral vaccines against enteric pathogens. We examined the effect of immunization with an oral live-attenuated Shigella dysenteriae 1 vaccine and challenge with wild-type S. dysenteri
Externí odkaz:
https://doaj.org/article/f161a02a8af64477bfa0c961f19a8d5d
Autor:
Courtney L Davis, Rezwanul Wahid, Franklin R Toapanta, Jakub K Simon, Marcelo B Sztein, Doron Levy
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e59465 (2013)
We establish a mathematical framework for studying immune interactions with Shigella, a bacteria that kills over one million people worldwide every year. The long-term goal of this novel approach is to inform Shigella vaccine design by elucidating wh
Externí odkaz:
https://doaj.org/article/334abb4a9de54999863fe2d718d1fc2c
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 2 (2012)
Following interaction with cognate antigens, B cells undergo cell activation, proliferation and differentiation. Ligation of the B cell receptor (BCR) leads to the phosphorylation of BCR-associated signaling proteins within minutes of antigen binding
Externí odkaz:
https://doaj.org/article/bfd6ba02550a416ab674256974ddc2e1