Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Franklin R Toapanta"'
Autor:
Franklin R. Toapanta, Jingping Hu, Kari Ann Shirey, Paula J. Bernal, Myron M. Levine, Thomas C. Darton, Claire S. Waddington, Andrew J. Pollard, Marcelo B. Sztein
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
An oral Controlled Human Infection Model (CHIM) with wild-type S. Typhi was re-established allowing us to explore the development of immunity. In this model, ~55% of volunteers who received the challenge reached typhoid diagnosis criteria (TD), while
Externí odkaz:
https://doaj.org/article/7f2e05bb0a404438a4c9919701980c1f
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionNon-typhoidal Salmonella (NTS) generally causes self-limiting gastroenteritis. However, older adults (≥65 years) can experience more severe outcomes from NTS infection. We have previously shown that a live attenuated S. Typhimurium vacc
Externí odkaz:
https://doaj.org/article/d083e0f41da24e1b88aa5c44f2b9a9ed
Autor:
Franklin R. Toapanta, Jingping Hu, Shiri Meron-Sudai, Laurence A. Mulard, Armelle Phalipon, Dani Cohen, Marcelo B. Sztein
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Shigellosis is common worldwide, and it causes significant morbidity and mortality mainly in young children in low- and middle- income countries. To date, there are not broadly available licensed Shigella vaccines. A novel type of conjugate vaccine c
Externí odkaz:
https://doaj.org/article/c126aa01bac14aeca8ea6a9a6c1b1b54
Autor:
Ana M. Hernandez, Jim A. Mossman, Franklin R. Toapanta, Dana M. Previte, Ted M. Ross, Gerard J. Nau
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-12 (2022)
Abstract Background Influenza causes a serious infection in older individuals who are at the highest risk for mortality from this virus. Changes in the immune system with age are well known. This study used transcriptomic analysis to evaluate how agi
Externí odkaz:
https://doaj.org/article/cf1c918ed0444b27a784bcc60ecc8b35
Autor:
Jessica C. Allen, Franklin R. Toapanta, Scott M. Baliban, Marcelo B. Sztein, Sharon M. Tennant
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionNon-typhoidal Salmonella (NTS) is responsible for a high burden of foodborne infections and deaths worldwide. In the United States, NTS infections are the leading cause of hospitalizations and deaths due to foodborne illnesses, and older
Externí odkaz:
https://doaj.org/article/0209e71e18a140f28306dcde7c8d2e2d
Autor:
Robert Edelman, Meagan E. Deming, Franklin R. Toapanta, Mark D. Heuser, Lisa Chrisley, Robin S. Barnes, Steven S. Wasserman, William C. Blackwelder, Barry S. Handwerger, Marcela Pasetti, Khan M. Siddiqui, Marcelo B. Sztein
Publikováno v:
Immunity & Ageing, Vol 17, Iss 1, Pp 1-16 (2020)
Abstract Background Reduced response to hepatitis B vaccines is associated with aging, confounding and comorbid conditions, as well as inadvertent subcutaneous (SC) inoculation. We hypothesized that the antibody and T cell-mediated immune responses (
Externí odkaz:
https://doaj.org/article/97d087551e654b738593dafe6a0aa4c6
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-17 (2018)
Abstract Background Shigellosis persists as a public health problem worldwide causing ~ 165,000 deaths every year, of which ~ 55,000 are in children less than 5 years of age. No vaccine against shigellosis is currently licensed. The live-attenuated S
Externí odkaz:
https://doaj.org/article/e80eac81af7546d0a653a8e74031f7ed
Autor:
Jayaum S. Booth, Franklin R. Toapanta
Publikováno v:
Vaccines, Vol 9, Iss 1, p 24 (2021)
B and T cells are key components of the adaptive immune system and coordinate multiple facets of immunity including responses to infection, vaccines, allergens, and the environment. In humans, B- and T-cell immunity has been determined using primaril
Externí odkaz:
https://doaj.org/article/7cf31a1ff3794384bb3ff0ca0e7566ce
Autor:
Franklin R Toapanta, Paula Bernal, Jingping Hu, Paul C Roberts, Catherine J Luke, Mamodikoe K Makhene, Justin Ortiz, Kathleen Neuzil, Marcelo Sztein
Publikováno v:
Open Forum Infectious Diseases. 9
Background Influenza vaccines require yearly updates due to constant antigenic drift. Improvement of current vaccines requires a deep understanding of the pathogen as well as immunity to the virus. Controlled Human Infection Models (CHIM) provide opp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb9cbf4a38d890511de49499c5c40695
https://doi.org/10.1093/ofid/ofac492.544
https://doi.org/10.1093/ofid/ofac492.544
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0189571 (2018)
We refine and clinically parameterize a mathematical model of the humoral immune response against Shigella, a diarrheal bacteria that infects 80-165 million people and kills an estimated 600,000 people worldwide each year. Using Latin hypercube sampl
Externí odkaz:
https://doaj.org/article/090fd3d1baec42aeabe4e134e4030698