Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Franklin Mayca Pozo"'
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112531- (2023)
Summary: Genomic instability can promote inflammation and tumor development. Previous research revealed an unexpected layer of regulation of genomic instability by a cytoplasmic protein MYO10; however, the underlying mechanism remained unclear. Here,
Externí odkaz:
https://doaj.org/article/6b40777165fc4f1ab69d94c579667f8d
Publikováno v:
Acta Materia Medica, Vol 1, Iss 2, Pp 193-196 (2022)
The classical phosphatidylinositol 3-kinases (PI3Ks) are heterodimers of p110 and p85. PIK3CA, the gene encoding the catalytic p110α subunit, is one of the most frequently mutated oncogenes in human cancers. Mutations have been observed to occur in
Externí odkaz:
https://doaj.org/article/c0449077793949a1a1f665dc5703003b
Autor:
Fangfang Wang, Sora Jin, Franklin Mayca Pozo, Danmei Tian, Xiyang Tang, Yi Dai, Xinsheng Yao, Jinshan Tang, Youwei Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 3, Pp 1339-1350 (2022)
DNA damage response (DDR) is a highly conserved genome surveillance mechanism that preserves cell viability in the presence of chemotherapeutic drugs. Hence, small molecules that inhibit DDR are expected to enhance the anti-cancer effect of chemother
Externí odkaz:
https://doaj.org/article/8072e7df692147dfa21278fcaad7299d
Autor:
Lei Zhang, Xinran Geng, Fangfang Wang, Jinshan Tang, Yu Ichida, Arishya Sharma, Sora Jin, Mingyue Chen, Mingliang Tang, Franklin Mayca Pozo, Wenxiu Wang, Janet Wang, Michal Wozniak, Xiaoxia Guo, Masaru Miyagi, Fulai Jin, Yongjie Xu, Xinsheng Yao, Youwei Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The 53BP1 protein is well-known for its involvement in double-strand break (DSB) repair. Here the authors show 53BP1 undergoes significant liquid-liquid phase separation (LLPS) to play a role in heterochromatin maintenance and identify distinct domai
Externí odkaz:
https://doaj.org/article/12205ecb810c4c64a97fa7a840c621aa
Autor:
Fangfang Wang, Franklin Mayca Pozo, Danmei Tian, Xinran Geng, Xinsheng Yao, Youwei Zhang, Jinshan Tang
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/232e2c3e6c6241b195eb499f1fe693df
Autor:
Fangfang Wang, Franklin Mayca Pozo, Danmei Tian, Xinran Geng, Xinsheng Yao, Youwei Zhang, Jinshan Tang
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Shikonin is a natural naphthoquinone compound and has demonstrated potent anti-cancer activities; however, the underlying molecular mechanisms remained elusive. Here we report that Shikonin inhibited the growth of a wide range of human cancer cell li
Externí odkaz:
https://doaj.org/article/98cdc45294c840fe9e6249602c419b83
Autor:
Lei Zhang, Xinran Geng, Fangfang Wang, Jinshan Tang, Yu Ichida, Arishya Sharma, Sora Jin, Mingyue Chen, Mingliang Tang, Franklin Mayca Pozo, Wenxiu Wang, Janet Wang, Michal Wozniak, Xiaoxia Guo, Masaru Miyagi, Fulai Jin, Yongjie Xu, Xinsheng Yao, Youwei Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/215d2c59610f47f1ae6e6cd804f8c5a8
Publikováno v:
Acta Mater Med
The classical phosphatidylinositol 3-kinases (PI3Ks) are heterodimers of p110 and p85. PIK3CA, the gene encoding the catalytic p110α subunit, is one of the most frequently mutated oncogenes in human cancers. Mutations have been observed to occur in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838d04e147e1e1b5348bd69278f01e7b
https://europepmc.org/articles/PMC10191166/
https://europepmc.org/articles/PMC10191166/
Autor:
John A. Hammer, Ernest G. Heimsath, Richard E. Cheney, Youwei Zhang, Mark W. Jackson, Ilaria Tamagno, Xinran Geng, Franklin Mayca Pozo
Publikováno v:
Science advances. 7(38)
Genomic instability is a hallmark of human cancer; yet the underlying mechanisms remain poorly understood. Here, we report that the cytoplasmic unconventional Myosin X (MYO10) regulates genome stability, through which it mediates inflammation in canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd248316b2e94174c37839a4f865a0b1
https://pubmed.ncbi.nlm.nih.gov/34524844
https://pubmed.ncbi.nlm.nih.gov/34524844
Autor:
Goutham Narla, Abbey L. Perl, Caitlin M. O’Connor, Junran Zhang, Youwei Zhang, Franklin Mayca Pozo, Pengyan Fa
Publikováno v:
J Biol Chem
Genomic replication is a highly regulated process and represents both a potential benefit and liability to rapidly dividing cells; however, the precise post-translational mechanisms regulating genomic replication are incompletely understood. Protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d42a5f906eb0a23e6463ed025bf024a
https://doi.org/10.1074/jbc.ra119.010432
https://doi.org/10.1074/jbc.ra119.010432