Supplementary Figures 1 - 6 from IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

Autor: Christian M. Metallo, Raymond Pagliarini, Anne N. Murphy, Matthew G. Vander Heiden, Joseph D. Growney, Christopher Straub, Erika D. Handly, Hong Yin, Franklin Chung, Carol Joud-Caldwell, Chad Vickers, Fallon Lin, Minying Pu, Kelly L. Slocum, Xiamei Zhang, Courtney R. Green, Ajit S. Divakaruni, Shawn M. Davidson, Seth J. Parker, Alexandra R. Grassian

PDF file - 348KB, Figure S1: Isogenic IDH1 mutation compromises metabolic reprogramming under hypoxia. Figure S2: Simulated and measured uncorrected MIDs. Figure S3: Compromised Reductive TCA Metabolism is specific to cells with mutant IDH1. Figure S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376c269450e5947866e21be024083aa0
https://doi.org/10.1158/0008-5472.22404444

Supplementary Methods, Figure Legends from IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

Autor: Christian M. Metallo, Raymond Pagliarini, Anne N. Murphy, Matthew G. Vander Heiden, Joseph D. Growney, Christopher Straub, Erika D. Handly, Hong Yin, Franklin Chung, Carol Joud-Caldwell, Chad Vickers, Fallon Lin, Minying Pu, Kelly L. Slocum, Xiamei Zhang, Courtney R. Green, Ajit S. Divakaruni, Shawn M. Davidson, Seth J. Parker, Alexandra R. Grassian

PDF file - 136KB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c83526185c0fd14582306beb658d0d3
https://doi.org/10.1158/0008-5472.22404441.v1

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss

Autor: Joseph D. Growney, Raymond Pagliarini, Li Li, Sosathya Sovath, Grainne Kerr, Javad Golji, Michael D. Jones, Michael R. Schlabach, Julie T. Chen, Rosalie deBeaumont, Kenzie MacIsaac, David A. Ruddy, Daniel P. Rakiec, Joshua M. Korn, Huayang Liu, Franklin Chung, Lauren K. Brodeur, E. Robert McDonald, Caroline Bullock

Publikováno v: Nature Medicine. 25:95-102

Interferons (IFNs) are cytokines that play a critical role in limiting infectious and malignant diseases 1-4 . Emerging data suggest that the strength and duration of IFN signaling can differentially impact cancer therapies, including immune checkpoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c32c0e3bf702ec758c8786c1f189005e
https://doi.org/10.1038/s41591-018-0302-5

IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

Autor: Erika Handly, Joseph D. Growney, Kelly Slocum, Anne N. Murphy, Courtney R. Green, Fallon Lin, Xiamei Zhang, Christian M. Metallo, Seth J. Parker, Chad Vickers, Christopher Straub, Alexandra R. Grassian, Matthew G. Vander Heiden, Raymond Pagliarini, Minying Pu, Ajit S. Divakaruni, Carol Joud-Caldwell, Franklin Chung, Hong Yin, Shawn M. Davidson

Publikováno v: Cancer research, vol 74, iss 12
Grassian, AR; Parker, SJ; Davidson, SM; Divakaruni, AS; Green, CR; Zhang, X; et al.(2014). IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Research, 74(12), 3317-3331. doi: 10.1158/0008-5472.CAN-14-0772-T. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/69g6m263
PMC

Oncogenic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in several types of cancer, but the metabolic consequences of these genetic changes are not fully understood. In this study, we performed 13C metabolic flux analysis on a panel of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82569fd8ce5f50271577681b756aaef
https://doi.org/10.1158/0008-5472.can-14-0772-t

Targeting HSF1 sensitizes cancer cells to HSP90 inhibition

Autor: Linda Bagdasarian, Fei Feng, Margaret E. McLaughlin, Jinyun Chen, Alice Loo, Yaoyu Chen, Raymond Pagliarini, Franklin Chung, Savina Jaeger, Frank Stegmeier, David A. Ruddy, Ping Zhu, Wenlai Zhou, Dale W. Porter, Ribo Guo, Jianjun Yu, Joshua M. Korn

Publikováno v: Oncotarget

// Yaoyu Chen 1,* , Jinyun Chen 1,* , Alice Loo 1 , Savina Jaeger 1 , Linda Bagdasarian 2 , Jianjun Yu 3 , Franklin Chung 1 , Joshua Korn 1 , David Ruddy 2 , Ribo Guo 1 , Margaret E. Mclaughlin 2 , Fei Feng 1 , Ping Zhu 1 , Frank Stegmeier 1 , Raymon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023303f3adffd5928124705c3227ba05
http://europepmc.org/articles/PMC3757240