Výsledky vyhledávání - "Franklin, Rjm"

The proteome of remyelination is different from that of developmental myelination

Autor: Lopes E, Franklin Rjm, de Faria Jp, Damaris Bausch-Fluck, Chao Zhao, Azevedo Mm, Montani L, João B. Relvas, Bernd Wollscheid, Rui Loja Fernandes, Ana I. Seixas, Monteiro Ma, Patrick G. A. Pedrioli, Helena S. Domingues

Loss of myelin underlies the pathology of several neurological disorders of diverse etiology. CNS remyelination by adult oligodendrocyte progenitor cells (OPCs) can occur but it differs from developmental myelination carried out by neonatal OPCs. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93104dca1c4769be5fa76fd542601fc0
https://doi.org/10.1101/2021.03.24.436006

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Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders

Autor: Conejos-Sánchez, I, Gallon, E, Niño-Pariente, A, Smith, JA, De la Fuente, AG, Di Canio, L, Pluchino, S, Franklin, RJM, Vicent, MJ

Gene silencing therapies have successfully suppressed the translation of target proteins, a strategy that holds great promise for the treatment of central nervous system (CNS) disorders. Advances in the current knowledge on multimolecular delivery ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d189d7ee2a771ba9c2486dd3a9212a8

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Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice

Autor: Kazanis, I, Evans, KA, Andreopoulou, E, Dimitriou, C, Koutsakis, C, Karadottir, RT, Franklin, RJM

Publikováno v: Stem Cell Reports
Stem Cell Reports, Vol 8, Iss 3, Pp 685-700 (2017)

Summary Two populations of oligodendrogenic progenitors co-exist within the corpus callosum (CC) of the adult mouse. Local, parenchymal oligodendrocyte progenitor cells (pOPCs) and progenitors generated in the subependymal zone (SEZ) cytogenic niche.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0d9241d7e440063a1712c3b9d6d735e6
http://europepmc.org/articles/PMC5355571

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Regenerating CNS myelin — from mechanisms to experimental medicines

Autor: Franklin, RJM

Although the core concept of remyelination — based on the activation, migration, proliferation and differentiation of CNS progenitors — has not changed over the past 20 years, our understanding of the detailed mechanisms that underlie this proces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce6c6a236d2d9dcd14b7c52b7fd9818
https://www.repository.cam.ac.uk/handle/1810/271092

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Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

Autor: Franklin, RJM

The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa22c12fed8e697756d8e0fa7b0e39d
https://www.repository.cam.ac.uk/handle/1810/267485

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Fibroblast growth factor signaling in oligodendrocyte-lineage cells facilitates recovery of chronically demyelinated lesions but is redundant in acute lesions

Autor: Furusho, M, Roulois, A, Franklin, RJM, Bansal, R

Remyelination is a potent regenerative process in demyelinating diseases, such as multiple sclerosis, the effective therapeutic promotion of which will fill an unmet clinical need. The development of pro-regenerative therapies requires the identifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d1444ea7a31c04329b193eca8132b92
https://europepmc.org/articles/PMC4534313/

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Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression

Autor: Tyzack, GE, Sitnikov, S, Barson, D, Adams-Carr, KL, Lau, NK, Kwok, JC, Zhao, C, Franklin, RJM, Karadottir, RT, Fawcett, JW, Lakatos, A

Publikováno v: Nature Communications

The role of remote astrocyte (AC) reaction to central or peripheral axonal insult is not clearly understood. Here we use a transgenic approach to compare the direct influence of normal with diminished AC reactivity on neuronal integrity and synapse r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b6d8b7329ac3685dd95e50b1090158e5
https://www.repository.cam.ac.uk/handle/1810/245879

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Piezochirurgische knöcherne Dekompression: Experimentelle Evaluierung und Erfahrungsbericht bei knöcherner Dekompression des Nervus Opticus

Autor: Kotter, MR, Widhalm, G, Vig, R, Widhalm, H, Franklin, RJM, Matula, C

Publikováno v: 59. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3. Joint Meeting mit der Italienischen Gesellschaft für Neurochirurgie (SINch); 20080601-20080604; Würzburg; DOCDI.02.08 /20080530/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1175::2e776af85748483467f5d548405c3251
http://www.egms.de/en/meetings/dgnc2008/08dgnc158.shtml

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