Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Franklin, Otu"'
Autor:
Christine Pattison, John R. Atack, Semantha Ellis, Franklin Otu, Alan Nadin, Huw D. Lewis, Mark T. Jay, Jerome Ma, Jonathan D. Best, Timothy Harrison, Toni Williamson, Michael Reilly, Mark S. Shearman
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 313:902-908
The efficacy of gamma-secretase inhibitors in vivo has, to date, been generally assessed in transgenic mouse models expressing increased levels of amyloid-beta (Abeta) peptide thereby allowing the detection of changes in Abeta production. However, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::760c9ce7165b473cba94a385e536810b
https://doi.org/10.1124/jpet.104.081174
https://doi.org/10.1124/jpet.104.081174
Autor:
Jonathan D. Best, John R. Atack, Christine Pattison, Ian Churcher, Tim Harrison, Mark T. Jay, Michael Reilly, Mark S. Shearman, Franklin Otu, Pablo Morentin-Gutierrez
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 317(2)
Plaques in the parenchyma of the brain containing Abeta peptides are one of the hallmarks of Alzheimer's disease. These Abeta peptides are produced by the final proteolytic cleavage of the amyloid precursor protein by the intramembraneous aspartyl pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783726d470af98f1f6769f8114234248
https://pubmed.ncbi.nlm.nih.gov/16443723
https://pubmed.ncbi.nlm.nih.gov/16443723
Autor:
Jonathan D, Best, Mark T, Jay, Franklin, Otu, Jerome, Ma, Alan, Nadin, Semantha, Ellis, Huw D, Lewis, Christine, Pattison, Michael, Reilly, Timothy, Harrison, Mark S, Shearman, Toni L, Williamson, John R, Atack
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 313(2)
The efficacy of gamma-secretase inhibitors in vivo has, to date, been generally assessed in transgenic mouse models expressing increased levels of amyloid-beta (Abeta) peptide thereby allowing the detection of changes in Abeta production. However, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11a549defd85d15e582ed5a7e9861c4c
https://pubmed.ncbi.nlm.nih.gov/15743924
https://pubmed.ncbi.nlm.nih.gov/15743924
Autor:
Frederick M. Kuenzi, Alison J. Smith, Neil Collinson, Wolfgang Jarolimek, Karen A. Maubach, Cyrille Sur, Rosa Cothliff, G. R. Dawson, Thomas W. Rosahl, John R. Atack, Guy R. Seabrook, Owain W. Howell, Ruth M. McKernan, Paul J. Whiting, Franklin Otu
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(13)
The alpha5 subunit of the GABA(A) receptor is localized mainly to the hippocampus of the mammalian brain. The significance of this rather distinct localization and the function of alpha5-containing GABA(A) receptors has been explored by targeted disr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fed4fb4e2d8bd3525c59a774cf17de9
https://pubmed.ncbi.nlm.nih.gov/12097508
https://pubmed.ncbi.nlm.nih.gov/12097508