Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Frankie D. Heyward"'
Autor:
Frankie D. Heyward, Nan Liu, Christopher Jacobs, Natalia L. S. Machado, Rachael Ivison, Aykut Uner, Harini Srinivasan, Suraj J. Patel, Anton Gulko, Tyler Sermersheim, Linus Tsai, Evan D. Rosen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract AgRP neurons in the arcuate nucleus of the hypothalamus (ARC) coordinate homeostatic changes in appetite associated with fluctuations in food availability and leptin signaling. Identifying the relevant transcriptional regulatory pathways in
Externí odkaz:
https://doaj.org/article/cb1199e1ff5441d09265e83f4a574091
Autor:
Suraj J. Patel, Nan Liu, Sam Piaker, Anton Gulko, Maynara L. Andrade, Frankie D. Heyward, Tyler Sermersheim, Nufar Edinger, Harini Srinivasan, Margo P. Emont, Gregory P. Westcott, Jay Luther, Raymond T. Chung, Shuai Yan, Manju Kumari, Reeby Thomas, Yann Deleye, André Tchernof, Phillip J. White, Guido A. Baselli, Marica Meroni, Dario F. De Jesus, Rasheed Ahmad, Rohit N. Kulkarni, Luca Valenti, Linus Tsai, Evan D. Rosen
Publikováno v:
Sci Transl Med
Inflammation has profound but poorly understood effects on metabolism, especially in the context of obesity and nonalcoholic fatty liver disease (NAFLD). Here, we report that hepatic interferon regulatory factor 3 (IRF3) is a direct transcriptional r
Autor:
Frankie D. Heyward, Nan Liu, Christopher Jacobs, Rachael Ivison, Natalia Machado, Aykut Uner, Harini Srinivasan, Suraj J. Patel, Anton Gulko, Tyler Sermersheim, Stuart H. Orkin, Linus Tsai, Evan D. Rosen
AgRP neurons in the arcuate nucleus of the hypothalamus (ARC) coordinate homeostatic changes in appetite associated with fluctuations in food availability and leptin signaling. Identifying the relevant transcriptional regulatory pathways in these neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b587b056ff94a8c93cdb3befb59dc569
https://doi.org/10.1101/2022.01.03.474708
https://doi.org/10.1101/2022.01.03.474708
Publikováno v:
Trends in Cell Biology. 32:1049
Publikováno v:
Diabetes. 69
AgRP neurons in the arcuate nucleus (ARC) of the hypothalamus play a dominant role in maintaining energy balance and are dysregulated in obesity, but prior studies examining their transcriptional regulation have been confounded by the rich cellular d
Autor:
Frankie D. Heyward, Evan D. Rosen
Publikováno v:
Diabetes. 67
The arcuate nucleus (ARC) of the hypothalamus is home to a wide assortment of cell types, many of which uniquely contribute to the regulation of energy homeostasis. Given the high degree of cellular heterogeneity present within the ARC, solutions are
Autor:
Frankie D. Heyward, J. David Sweatt
Publikováno v:
The Neuroscientist. 21:475-489
The establishment of synaptic plasticity and long-term memory requires lasting cellular and molecular modifications that, as a whole, must endure despite the rapid turnover of their constituent parts. Such a molecular feat must be mediated by a stabl
Autor:
Trieu R, Jing Wang, Cristin F. Gavin, Gilliam D, Moulden J, Coleman Ma, Frankie D. Heyward, Garrett A. Kaas, J. D. Sweatt, John W. Lewis
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(4)
Aberrant gene expression within the hippocampus has recently been implicated in the pathogenesis of obesity-induced memory impairment. Whether a dysregulation of epigenetic modifications mediates this disruption in gene transcription has yet to be es
Publikováno v:
Behavioural brain research. 253
2,4,5 dihydro 2,5 trimethylthiazoline (TMT) is a synthesized component of red fox anal secretions that reliably elicits defensive behaviors in rats and mice. TMT differs from other predator odors because it is a single molecule, it can be synthesized
Autor:
W. Timothy Garvey, R. Grace Walton, Frankie D. Heyward, Matthew S. Carle, Mark A. Coleman, J. David Sweatt
Mounting evidence has established that diet-induced obesity (DIO) is associated with deficits in hippocampus-dependent memory. The bulk of research studies dealing with this topic have utilized rats fed a high-fat diet as an experimental model. To da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf27430a2cf44ea9bf0eb98cd7b11a79
https://europepmc.org/articles/PMC3389577/
https://europepmc.org/articles/PMC3389577/