Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Frankie Chiu"'
Autor:
Lorena Maili, Bhavna Tandon, Qiuping Yuan, Simone Menezes, Frankie Chiu, S. Shahrukh Hashmi, Ariadne Letra, George T. Eisenhoffer, Jacqueline T. Hecht
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Craniofacial development is a complex and tightly regulated process and disruptions can lead to structural birth defects, the most common being nonsyndromic cleft lip and palate (NSCLP). Previously, we identified FOS as a candidate regulator of NSCLP
Externí odkaz:
https://doaj.org/article/b8947a3aa9854a0798e4c7d5d1bfb66c
Autor:
Lorena Maili, Oscar E. Ruiz, Philip H. Kahan, Frankie Chiu, Stephen T. Larson, S. Shahrukh Hashmi, Jacqueline T. Hecht, George T. Eisenhoffer
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/a3ff8240280d45c0b8a8a920f3710f7b
Autor:
Jacqueline T. Hecht, Alka C. Veerisetty, Debabrata Patra, Mohammad G. Hossain, Frankie Chiu, Claire Mobed, Francis H. Gannon, Karen L. Posey
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1553 (2023)
Pseudoachondroplasia (PSACH), a severe dwarfing condition associated with early-onset joint degeneration and lifelong joint pain, is caused by mutations in cartilage oligomeric matrix protein (COMP). The mechanisms underlying the mutant-COMP patholog
Externí odkaz:
https://doaj.org/article/b610757a893145d5a7269de90cf02d63
Publikováno v:
Matrix Biology. 119:101-111
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dcb27afcfe4744a5f2a4198aba97846
https://doi.org/10.1016/j.matbio.2023.03.008
https://doi.org/10.1016/j.matbio.2023.03.008
Autor:
Lorena Maili, Oscar E. Ruiz, Philip Kahan, Frankie Chiu, Stephen T. Larson, S. Shahrukh Hashmi, Jacqueline T. Hecht, George T. Eisenhoffer
Publikováno v:
Disease Models & Mechanisms.
Facial development requires a complex and coordinated series of cellular events, that when perturbed, can lead to structural birth defects. A quantitative approach to quickly assess morphological changes could address how genetic or environmental inp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97c8ba98fe17308461afbbdd09365e50
https://doi.org/10.1242/dmm.049868
https://doi.org/10.1242/dmm.049868
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3845
Volume 24
Issue 4
Pages: 3845
Mutations in cartilage oligomeric matrix protein (COMP) causes protein misfolding and accumulation in chondrocytes that compromises skeletal growth and joint health in pseudoachondroplasia (PSACH), a severe dwarfing condition. Using the MT-COMP mice,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685b9366363063f88f3c2e7e87a0c9da
Autor:
Francoise Coustry, Karen L. Posey, Alka C. Veerisetty, Frankie Chiu, Mohammad G. Hossain, Francis H. Gannon, Jacqueline T. Hecht, Juliana Wu
Publikováno v:
Am J Pathol
Increasing numbers of people are living with osteoarthritis (OA) due to aging and obesity, creating an urgent need for effective treatment and preventions. Two top risk factors for OA, age and obesity, are associated with endoplasmic reticulum (ER) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55442fa40ef6d70bac07989f15cb2398
https://doi.org/10.1016/j.ajpath.2021.05.016
https://doi.org/10.1016/j.ajpath.2021.05.016
Autor:
Jacqueline T. Hecht, Francoise Coustry, Debabrata Patra, Alka C. Veerisetty, Frankie Chiu, Mohammad G. Hossain, Karen L. Posey
Pseudoachondroplasia (PSACH), a short limb skeletal dysplasia, associated with premature joint degeneration is caused by misfolding mutations in cartilage oligomeric matrix protein (COMP). Here, we define mutant-COMP-induced stress mechanisms that oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb4769245b4160ff3fcf9aaacdc67488
https://doi.org/10.1101/2021.06.04.447121
https://doi.org/10.1101/2021.06.04.447121
Autor:
Alka C. Veerisetty, Frankie Chiu, Joseph L. Alcorn, Karen L. Posey, Jacqueline T. Hecht, Mohammad G. Hossain
Publikováno v:
Osteoarthritis and Cartilage. 28:S194
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13203b8beb580bc727e5833020ac0fc3
https://doi.org/10.1016/j.joca.2020.02.315
https://doi.org/10.1016/j.joca.2020.02.315
Autor:
Lindsay Remer, Frankie Chiu, Jacqueline T. Hecht, Karen L. Posey, Alka C. Veerisetty, Annie M. Abraham, Mohammad G. Hossain, Tristan Maerz, Sabah Nobakhti, Francoise Coustry, Michael D. Newton, Kevin C. Baker, Karissa Gawronski, Sandra J. Shefelbine, Xiaohong Bi, Catherine G. Ambrose
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology. 67
Mutations in COMP (cartilage oligomeric matrix protein) cause severe long bone shortening in mice and humans. Previously, we showed that massive accumulation of misfolded COMP in the ER of growth plate chondrocytes in our MT-COMP mouse model of pseud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a92cef65f59e5a52a3f2b478b71db23
https://pubmed.ncbi.nlm.nih.gov/29309831
https://pubmed.ncbi.nlm.nih.gov/29309831