Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection.

Autor: Tang AT; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Buchholz DW; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America., Szigety KM; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Imbiakha B; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America., Gao S; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Frankfurter M; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Wang M; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Yang J; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Hewins P; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America., Mericko-Ishizuka P; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Leu NA; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, United States of America., Sterling S; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, United States of America., Monreal IA; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America., Sahler J; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America., August A; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America., Zhu X; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Jurado KA; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America., Xu M; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Morrisey EE; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America., Millar SE; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Aguilar HC; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America., Kahn ML; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

Publikováno v: PLoS biology [PLoS Biol] 2023 Feb 06; Vol. 21 (2), pp. e3001989. Date of Electronic Publication: 2023 Feb 06 (Print Publication: 2023).

SARS-CoV-2 infection of olfactory epithelial cells and neurons drives acute lung injury and lethal COVID-19 in mice.

Autor: Tang AT, Buchholz DW, Szigety KM, Imbhiaka B, Gao S, Frankfurter M, Wang M, Yang J, Hewins P, Mericko-Ishizuka P, Adrian Leu N, Sterling S, Monreal IA, Sahler J, August A, Zhu X, Jurado KA, Xu M, Morrisey EE, Millar SE, Aguilar HC, Kahn ML

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2021 Dec 07. Date of Electronic Publication: 2021 Dec 07.

Overexpression of Desmoglein 2 in a Mouse Model of Gorlin Syndrome Enhances Spontaneous Basal Cell Carcinoma Formation through STAT3-Mediated Gli1 Expression.

Autor: Brennan-Crispi DM; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Sydney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Biochemistry and Pharmacology Graduate Program, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Overmiller AM; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Biochemistry and Pharmacology Graduate Program, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Tamayo-Orrego L; Molecular Biology of Neural Development, Institut de Recherches Cliniques de Montréal (IRCM) Montreal, Quebec, Canada; Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada., Marous MR; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Sahu J; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., McGuinn KP; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Cooper F; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Georgiou IC; Leeds Institute of Cancer and Pathology, University of Leeds, UK; School of Molecular and Cellular Biology, University of Leeds, United Kingdom., Frankfurter M; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Salas-Alanis JC; Center for Molecular Diagnostics and Personalized Medicine, University of Monterrey, Mexico., Charron F; Molecular Biology of Neural Development, Institut de Recherches Cliniques de Montréal (IRCM) Montreal, Quebec, Canada; Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada; Department of Biology, Department of Anatomy and Cell Biology, and Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Medicine, University of Montreal, Montreal, Quebec, Canada., Millar SE; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Mahoney MG; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Sydney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address: My.Mahoney@jefferson.edu., Riobo-Del Galdo NA; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Sydney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Leeds Institute of Cancer and Pathology, University of Leeds, UK; School of Molecular and Cellular Biology, University of Leeds, United Kingdom. Electronic address: N.A.Riobo-DelGaldo@leeds.ac.uk.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2019 Feb; Vol. 139 (2), pp. 300-307. Date of Electronic Publication: 2018 Oct 03.

SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir.

Autor: Mesci, Pinar¹ (AUTHOR), de Souza, Janaina S.¹ (AUTHOR), Martin-Sancho, Laura² (AUTHOR), Macia, Angela¹ (AUTHOR), Saleh, Aurian¹ (AUTHOR), Yin, Xin² (AUTHOR), Snethlage, Cedric¹ (AUTHOR), Adams, Jason W.¹ (AUTHOR), Avansini, Simoni H.^1,3 (AUTHOR), Herai, Roberto H.^4,5 (AUTHOR), Almenar-Queralt, Angels¹ (AUTHOR), Pu, Yuan² (AUTHOR), Szeto, Ryan A.¹ (AUTHOR), Goldberg, Gabriela¹ (AUTHOR), Bruck, Patrick T.¹ (AUTHOR), Papes, Fabio^1,6 (AUTHOR), Chanda, Sumit K.² (AUTHOR), Muotri, Alysson R.^1,7,8,9 (AUTHOR) muotri@ucsd.edu

Publikováno v: PLoS Biology. 11/3/2022, Vol. 20 Issue 11, p1-23. 23p. 2 Color Photographs, 1 Diagram.

Getting Pregnant with PCOS.

Autor: Frankfurter, David

Publikováno v: Case-Based Guide to Clinical Endocrinology; 2015, p317-326, 10p