Ageing of Plasmodium falciparum malaria sporozoites alters their motility, infectivity and reduces immune activation in vitro.

Autor: van Schuijlenburg R; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, Netherlands., Azargoshasb S; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands., de Korne CM; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, Netherlands.; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands., Sijtsma JC; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, Netherlands., Bezemer S; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, Netherlands., van der Ham AJ; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, Netherlands., Baalbergen E; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, Netherlands., Geurten F; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, Netherlands., de Bes-Roeleveld LM; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, Netherlands., Chevalley-Maurel SC; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, Netherlands., van Oosterom MN; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands., van Leeuwen FWB; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands., Franke-Fayard B; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, Netherlands., Roestenberg M; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, Netherlands. M.Roestenberg@lumc.nl.

Publikováno v: Malaria journal [Malar J] 2024 Apr 19; Vol. 23 (1), pp. 111. Date of Electronic Publication: 2024 Apr 19.

The effect of dosage on the protective efficacy of whole-sporozoite formulations for immunization against malaria.

Autor: Moita D; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal., Rôla C; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal., Nunes-Cabaço H; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal., Nogueira G; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal., Maia TG; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal., Othman AS; Faculty of Health Sciences, Universiti Sultan Zainal Abidin, 21300, Terengganu, Malaysia., Franke-Fayard B; Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands., Janse CJ; Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands., Mendes AM; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal. ambmendes@gmail.com., Prudêncio M; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal. mprudencio@medicina.ulisboa.pt.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2023 Nov 24; Vol. 8 (1), pp. 182. Date of Electronic Publication: 2023 Nov 24.

A versatile Plasmodium falciparum reporter line expressing NanoLuc enables highly sensitive multi-stage drug assays.

Autor: Miyazaki Y; Department of Molecular Infection Dynamics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 852-8523, Nagasaki, Japan. y.miyazaki@nagasaki-u.ac.jp.; Department of Parasitology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands. y.miyazaki@nagasaki-u.ac.jp.; Department of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan. y.miyazaki@nagasaki-u.ac.jp., Vos MW; TropIQ Health Sciences, Transistorweg 5, 6534 AT, Nijmegen, The Netherlands., Geurten FJA; Department of Parasitology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands., Bigeard P; Sorbonne Université, Inserm, CNRS, Centre d'Immunologie et des Maladies Infectieuses, CIMI-Paris, F-75013, Paris, France., Kroeze H; Department of Parasitology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands., Yoshioka S; Graduate School of Pharmaceutical Sciences, Osaka University, 565-0871, Osaka, Japan., Arisawa M; Graduate School of Pharmaceutical Sciences, Osaka University, 565-0871, Osaka, Japan., Inaoka DK; Department of Molecular Infection Dynamics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 852-8523, Nagasaki, Japan.; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, 852-8523, Japan.; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan., Soulard V; Sorbonne Université, Inserm, CNRS, Centre d'Immunologie et des Maladies Infectieuses, CIMI-Paris, F-75013, Paris, France., Dechering KJ; TropIQ Health Sciences, Transistorweg 5, 6534 AT, Nijmegen, The Netherlands., Franke-Fayard B; Department of Parasitology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands., Miyazaki S; Department of Parasitology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands. smiyazaki@nagasaki-u.ac.jp.; Department of Cellular Architecture Studies, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 852-8523, Nagasaki, Japan. smiyazaki@nagasaki-u.ac.jp.

Publikováno v: Communications biology [Commun Biol] 2023 Jul 12; Vol. 6 (1), pp. 713. Date of Electronic Publication: 2023 Jul 12.

Glycosylated nanoparticle-based PfCSP vaccine confers long-lasting antibody responses and sterile protection in mouse malaria model.

Autor: Ludwig J; B Cell Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Scally SW; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada., Costa G; Vector Biology Unit, Max Planck Institute for Infection Biology, Berlin, Germany., Hoffmann S; B Cell Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Murugan R; B Cell Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Lossin J; B Cell Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Prieto K; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada., Obraztsova A; B Cell Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Lobeto N; B Cell Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Franke-Fayard B; Malaria Research Group, Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Janse CJ; Malaria Research Group, Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Lebas C; Vaccine Formulation Institute, Plan-les-Ouates, Switzerland., Collin N; Vaccine Formulation Institute, Plan-les-Ouates, Switzerland., Binter S; Kymab a Sanofi Company, Babraham Research Campus, Cambridge, UK., Kellam P; Kymab a Sanofi Company, Babraham Research Campus, Cambridge, UK.; Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK., Levashina EA; Vector Biology Unit, Max Planck Institute for Infection Biology, Berlin, Germany. levashina@mpiib-berlin.mpg.de., Wardemann H; B Cell Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany. h.wardemann@dkfz.de., Julien JP; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada. jean-philippe.julien@sickkids.ca.; Department of Immunology, University of Toronto, Toronto, ON, Canada. jean-philippe.julien@sickkids.ca.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada. jean-philippe.julien@sickkids.ca.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2023 Apr 07; Vol. 8 (1), pp. 52. Date of Electronic Publication: 2023 Apr 07.

Sporozoite immunization: innovative translational science to support the fight against malaria.

Autor: Richie TL; Sanaria Inc, Rockville, MD, USA., Church LWP; Sanaria Inc, Rockville, MD, USA., Murshedkar T; Sanaria Inc, Rockville, MD, USA., Billingsley PF; Sanaria Inc, Rockville, MD, USA., James ER; Sanaria Inc, Rockville, MD, USA., Chen MC; Sanaria Inc, Rockville, MD, USA., Abebe Y; Sanaria Inc, Rockville, MD, USA., Natasha Kc; Sanaria Inc, Rockville, MD, USA., Chakravarty S; Sanaria Inc, Rockville, MD, USA., Dolberg D; Sanaria Inc, Rockville, MD, USA., Healy SA; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Diawara H; Malaria Research and Training Center, Mali-NIAID ICER, University of Science, Techniques and Technologies of Bamako, Bamako, Mali., Sissoko MS; Malaria Research and Training Center, Mali-NIAID ICER, University of Science, Techniques and Technologies of Bamako, Bamako, Mali., Sagara I; Malaria Research and Training Center, Mali-NIAID ICER, University of Science, Techniques and Technologies of Bamako, Bamako, Mali., Cook DM; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Epstein JE; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Mordmüller B; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.; Institut für Tropenmedizin, Universitätsklinikum Tübingen, Tübingen, Germany., Kapulu M; Biosciences Department, Kenya Medical Research Institute KEMRI-Wellcome Research Programme, Kilifi, Kenya.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kreidenweiss A; Institut für Tropenmedizin, Universitätsklinikum Tübingen, Tübingen, Germany.; German Center for Infection Research (DZIF), partner site Tübingen, Tübingen, Germany., Franke-Fayard B; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Agnandji ST; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon., López Mikue MA; Ministry of Health and Social Welfare, Government of Equatorial Guinea, Malabo, Equatorial Guinea., McCall MBB; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.; Institut für Tropenmedizin, Universitätsklinikum Tübingen, Tübingen, Germany.; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon., Steinhardt L; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA., Oneko M; Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya., Olotu A; Bagamoyo Research and Training Center, Ifakara Health Institute, Bagamoyo, Tanzania., Vaughan AM; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington, Seattle, WA, USA., Kublin JG; Department of Global Health, University of Washington, Seattle, WA, USA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Murphy SC; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.; Center for Emerging and Re-emerging Infectious Diseases and Department of Microbiology, University of Washington, Seattle, WA, USA., Jongo S; Bagamoyo Research and Training Center, Ifakara Health Institute, Bagamoyo, Tanzania., Tanner M; Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland., Sirima SB; Groupe de Recherche Action en Santé (GRAS), Ouagadougou, Burkina Faso., Laurens MB; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA., Daubenberger C; Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland., Silva JC; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Lyke KE; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA., Janse CJ; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Roestenberg M; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands., Sauerwein RW; Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands., Abdulla S; Bagamoyo Research and Training Center, Ifakara Health Institute, Bagamoyo, Tanzania., Dicko A; Malaria Research and Training Center, Mali-NIAID ICER, University of Science, Techniques and Technologies of Bamako, Bamako, Mali., Kappe SHI; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington, Seattle, WA, USA., Sim BKL; Sanaria Inc, Rockville, MD, USA., Duffy PE; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Kremsner PG; Institut für Tropenmedizin, Universitätsklinikum Tübingen, Tübingen, Germany.; German Center for Infection Research (DZIF), partner site Tübingen, Tübingen, Germany.; Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon., Hoffman SL; Sanaria Inc, Rockville, MD, USA.

Publikováno v: Expert review of vaccines [Expert Rev Vaccines] 2023 Jan-Dec; Vol. 22 (1), pp. 964-1007. Date of Electronic Publication: 2023 Aug 11.