Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Frank-Gerrit Klärner"'
Autor:
Zizheng Li, Ibrar Siddique, Inesa Hadrović, Abbna Kirupakaran, Jiwen Li, Ye Zhang, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Li et al. design and synthesize fluorescently labeled molecular tweezers to explore their internalization, intracellular localization, and mechanism of endocytosis in brain cells including neurons and astrocytes. The authors find that MTs are interna
Externí odkaz:
https://doaj.org/article/a8efc1bcc1c2445089da253cba6fbb65
Autor:
Jing Di, Ibrar Siddique, Zizheng Li, Ghattas Malki, Simon Hornung, Suman Dutta, Ian Hurst, Ella Ishaaya, Austin Wang, Sally Tu, Ani Boghos, Ida Ericsson, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-20 (2021)
Abstract Background Molecular tweezers (MTs) are broad-spectrum inhibitors of abnormal protein aggregation. A lead MT, called CLR01, has been demonstrated to inhibit the aggregation and toxicity of multiple amyloidogenic proteins in vitro and in vivo
Externí odkaz:
https://doaj.org/article/ba33610ac54a4684912c0d07bf7103eb
Autor:
Nora Bengoa-Vergniory, Emilie Faggiani, Paula Ramos-Gonzalez, Ecem Kirkiz, Natalie Connor-Robson, Liam V. Brown, Ibrar Siddique, Zizheng Li, Siv Vingill, Milena Cioroch, Fabio Cavaliere, Sarah Threlfell, Bradley Roberts, Thomas Schrader, Frank-Gerrit Klärner, Stephanie Cragg, Benjamin Dehay, Gal Bitan, Carlos Matute, Erwan Bezard, Richard Wade-Martins
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
CLR01 is a molecular tweezer that inhibits protein aggregation. Here the authors show that CLR01 protects dopaminergic neurons in vitro and in vivo in human neurons and in mouse models showing potential as a disease-modifying therapy for Parkinson’
Externí odkaz:
https://doaj.org/article/dbb405cbb99f4bdb826102e5b534b7da
Autor:
Jing Di, Ibrar Siddique, Zizheng Li, Ghattas Malki, Simon Hornung, Suman Dutta, Ian Hurst, Ella Ishaaya, Austin Wang, Sally Tu, Ani Boghos, Ida Ericsson, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-3 (2021)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/5087cbf4709644eca3aebb77bf30135c
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Molecular tweezers (MTs) are supramolecular host molecules equipped with two aromatic pincers linked together by a spacer (Gakh, 2018). They are endowed with fascinating properties originating from their ability to hold guests between their aromatic
Externí odkaz:
https://doaj.org/article/b65d54f6751b4c08b6fcecf3ac6f0e23
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 8 (2017)
BackgroundCompromised protein quality control causes the accumulation of misfolded proteins and intracellular aggregates, contributing to cardiac disease and heart failure. The development of therapeutics directed at proteotoxicity‐based pathology
Externí odkaz:
https://doaj.org/article/42995bb0396b4dfc8cd4ac5ad236510e
Autor:
Edina Lump, Laura M Castellano, Christoph Meier, Janine Seeliger, Nelli Erwin, Benjamin Sperlich, Christina M Stürzel, Shariq Usmani, Rebecca M Hammond, Jens von Einem, Gisa Gerold, Florian Kreppel, Kenny Bravo-Rodriguez, Thomas Pietschmann, Veronica M Holmes, David Palesch, Onofrio Zirafi, Drew Weissman, Andrea Sowislok, Burkhard Wettig, Christian Heid, Frank Kirchhoff, Tanja Weil, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan, Elsa Sanchez-Garcia, Roland Winter, James Shorter, Jan Münch
Publikováno v:
eLife, Vol 4 (2015)
Semen is the main vector for HIV transmission and contains amyloid fibrils that enhance viral infection. Available microbicides that target viral components have proven largely ineffective in preventing sexual virus transmission. In this study, we es
Externí odkaz:
https://doaj.org/article/0c9550c7aa694a08a411342bf36bd1d9
Autor:
Tatjana Weil, Abbna Kirupakaran, My-Hue Le, Philipp Rebmann, Joel Mieres-Perez, Leila Issmail, Carina Conzelmann, Janis A. Müller, Lena Rauch, Andrea Gilg, Lukas Wettstein, Rüdiger Groß, Clarissa Read, Tim Bergner, Sandra Axberg Pålsson, Nadja Uhlig, Valentina Eberlein, Heike Wöll, Frank-Gerrit Klärner, Steffen Stenger, Beate M. Kümmerer, Hendrik Streeck, Giorgio Fois, Manfred Frick, Peter Braubach, Anna-Lena Spetz, Thomas Grunwald, James Shorter, Elsa Sanchez-Garcia, Thomas Schrader, Jan Münch
Publikováno v:
JACS Au
The COVID-19 pandemic caused by SARS-CoV-2 presents a global health emergency. Therapeutic options against SARS-CoV-2 are still very limited but urgently required. Molecular tweezers are supramolecular agents that destabilize the envelope of viruses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e23a0fa6926dc7b1800439d47a6417
Autor:
Frank-Gerrit Klärner, Jiwen Li, Inesa Hadrovic, Ye Zhang, Abbna Kirupakaran, Gal Bitan, Thomas Schrader, Zizheng Li, Ibrar Siddique
Publikováno v:
Communications Biology
Communications biology, vol 4, iss 1
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications biology, vol 4, iss 1
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Lysine-selective molecular tweezers are promising drug candidates against proteinopathies, viral infection, and bacterial biofilm. Despite demonstration of their efficacy in multiple cellular and animal models, important questions regarding their mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8576a79d6f8722b7a1da7a6f05ff803
https://doi.org/10.1038/s42003-021-02603-2
https://doi.org/10.1038/s42003-021-02603-2
Autor:
Edoardo Nusco, Irene Sambri, Vincenzo Cacace, Veronica Maffia, Antonio Monaco, Frank-Gerrit Klärner, Alessandro Fraldi, Yulia Ezhova, Nicolina Cristina Sorrentino, Gal Bitan, Teresa Giuliano, Elvira De Leonibus, Maria De Risi, Thomas Schrader
Publikováno v:
Molecular Therapy
Molecular therapy : the journal of the American Society of Gene Therapy, vol 28, iss 4
Molecular therapy : the journal of the American Society of Gene Therapy, vol 28, iss 4
Lysosomal storage diseases (LSDs) are inherited disorders caused by lysosomal deficiencies and characterized by dysfunction of the autophagy-lysosomal pathway (ALP) often associated with neurodegeneration. No cure is currently available to treat neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6803f3f17b23940eec5eb5563a48585c
https://doi.org/10.1016/j.ymthe.2022.10.001
https://doi.org/10.1016/j.ymthe.2022.10.001