Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Frank de Kievit"'
Autor:
Jordi Remon, Aurelie Swalduz, David Planchard, Sandra Ortiz-Cuaran, Laura Mezquita, Ludovic Lacroix, Cecile Jovelet, Etienne Rouleau, Camille Leonce, Frank De Kievit, Clive Morris, Greg Jones, Kelly Mercier, Karen Howarth, Emma Green, Maurice Pérol, Pierre Saintigny, Benjamin Besse
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234302 (2020)
Circulating tumor DNA (ctDNA)-based molecular profiling is rapidly gaining traction in clinical practice of advanced cancer patients with multi-gene next-generation sequencing (NGS) panels. However, clinical outcomes remain poorly described and deser
Externí odkaz:
https://doaj.org/article/93ae8d067940452fb391568395e4fc0e
Autor:
Vincent Plagnol, Samuel Woodhouse, Karen Howarth, Stefanie Lensing, Matt Smith, Michael Epstein, Mikidache Madi, Sarah Smalley, Catherine Leroy, Jonathan Hinton, Frank de Kievit, Esther Musgrave-Brown, Colin Herd, Katherine Baker-Neblett, Will Brennan, Peter Dimitrov, Nathan Campbell, Clive Morris, Nitzan Rosenfeld, James Clark, Davina Gale, Jamie Platt, John Calaway, Greg Jones, Tim Forshew
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193802 (2018)
Circulating tumor DNA (ctDNA) analysis is being incorporated into cancer care; notably in profiling patients to guide treatment decisions. Responses to targeted therapies have been observed in patients with actionable mutations detected in plasma DNA
Externí odkaz:
https://doaj.org/article/913109ecaadf42f485c31e026d8daca3
Autor:
David Planchard, Pierre Saintigny, Jean-Yves Blay, Benjamin Besse, Maurice Perol, Jean-François Guichou, Sylvie Chabaud, Luc Friboulet, Emma Green, Clive Morris, Karen Howarth, Frank de Kievit, Natalie Hoog-Labouret, Celine Mahier-Aït Oukhatar, Caroline Caramella, Etienne Giroux Leprieur, Isabelle Monnet, Etienne Brain, Radj Gervais, Christine Raynaud, Claire Tissot, Maud Ngo-Camus, Virginie Westeel, Yohann Loriot, Ludovic Lacroix, Washington R. Chumbi Flores, Virginie Avrillon, Anne Pradines, Cecile Jovelet, Camille Leonce, Julien Mazieres, Mihalea Aldea, Aurélie Swalduz, Laura Mezquita, Sandra Ortiz-Cuaran
Purpose:The limited knowledge on the molecular profile of patients with BRAF-mutant non–small cell lung cancer (NSCLC) who progress under BRAF-targeted therapies (BRAF-TT) has hampered the development of subsequent therapeutic strategies for these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ac9163cfbba9d2de50090974b699f2
https://doi.org/10.1158/1078-0432.c.6530096
https://doi.org/10.1158/1078-0432.c.6530096
Autor:
Yohann Loriot, Celine Mahier Ait Oukhatar, Benjamin Besse, S. Ortiz-Cuaran, Washington René Chumbi Flores, Jean-Yves Blay, Etienne Giroux Leprieur, Ludovic Lacroix, Mihaela Aldea, Claire Tissot, Clive Morris, Caroline Caramella, Julien Mazieres, Radj Gervais, Karen Howarth, Maurice Perol, Emma Green, Pierre Saintigny, Isabelle Monnet, C. Raynaud, Virginie Westeel, V. Avrillon, Etienne Brain, Jean-François Guichou, Camille Leonce, Maud Ngo-Camus, Anne Pradines, Frank de Kievit, Laura Mezquita, Sylvie Chabaud, Aurélie Swalduz, Cécile Jovelet, David Planchard, Luc Friboulet, N. Hoog-Labouret
Publikováno v:
Clinical Cancer Research
Purpose:The limited knowledge on the molecular profile of patients with BRAF-mutant non–small cell lung cancer (NSCLC) who progress under BRAF-targeted therapies (BRAF-TT) has hampered the development of subsequent therapeutic strategies for these
Autor:
Frank de Kievit, Laura Mezquita, Cécile Jovelet, David Planchard, Pierre Fournel, Christophe Massard, Luc Friboulet, Edouard Auclin, Emma Green, Solène Marteau, Pierre Saintigny, Caroline Caramella, Clive Morris, Jose Carlos Benitez, Maurice Perol, Benjamin Besse, Samuel Woodhouse, Aurélie Swalduz, K. Howarth, Etienne Rouleau, Claudio Nicotra, Julien Adam, Vincent Plagnol, Luc Odier, Claire Tissot, V. Avrillon, Ludovic Lacroix, Sandra Ortiz-Cuaran, Jordi Remon, Gonzalo Recondo
Publikováno v:
JCO Precision Oncology
JCO Precis Oncol
JCO Precis Oncol
PURPOSE Liquid biopsy specimen genomic profiling is integrated in non–small-cell lung cancer (NSCLC) guidelines; however, data on the clinical relevance for ALK /ROS1 alterations are scarce. We evaluated the clinical utility of a targeted amplicon-
Autor:
Sandra, Ortiz-Cuaran, Laura, Mezquita, Aurélie, Swalduz, Mihalea, Aldea, Julien, Mazieres, Camille, Leonce, Cecile, Jovelet, Anne, Pradines, Virginie, Avrillon, Washington R, Chumbi Flores, Ludovic, Lacroix, Yohann, Loriot, Virginie, Westeel, Maud, Ngo-Camus, Claire, Tissot, Christine, Raynaud, Radj, Gervais, Etienne, Brain, Isabelle, Monnet, Etienne, Giroux Leprieur, Caroline, Caramella, Celine, Mahier-Aït Oukhatar, Natalie, Hoog-Labouret, Frank, de Kievit, Karen, Howarth, Clive, Morris, Emma, Green, Luc, Friboulet, Sylvie, Chabaud, Jean-François, Guichou, Maurice, Perol, Benjamin, Besse, Jean-Yves, Blay, Pierre, Saintigny, David, Planchard
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 26(23)
The limited knowledge on the molecular profile of patients withThis was a prospective study of 78 patients with advancedctDNA sequencing is clinically relevant for the detection of
Autor:
James H. Clark, Sarah Smalley, Mikidache Madi, Will Brennan, Karen Howarth, Samuel Woodhouse, Katherine Baker-Neblett, Peter N. Dimitrov, Vincent Plagnol, Stefanie Lensing, Jamie Platt, Frank de Kievit, Michael Epstein, Esther Musgrave-Brown, Catherine Leroy, John Calaway, Tim Forshew, Nathan Campbell, Clive Morris, Matt Smith, Nitzan Rosenfeld, Davina Gale, Greg Jones, Jonathan Hinton, Colin Herd
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 3, p e0193802 (2018)
PLOS ONE
PLoS ONE, Vol 13, Iss 3, p e0193802 (2018)
PLOS ONE
Circulating tumor DNA (ctDNA) analysis is being incorporated into cancer care; notably in profiling patients to guide treatment decisions. Responses to targeted therapies have been observed in patients with actionable mutations detected in plasma DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f0357db496e8ab28b5ba0a25b7ac61
https://www.repository.cam.ac.uk/handle/1810/278128
https://www.repository.cam.ac.uk/handle/1810/278128
Abstract 1841: Integrative analysis of resistance to BRAF-targeted therapies in lung adenocarcinomas
Autor:
Pierre Saintingy, Solène Marteau, Anne Pradines, Karen Howarth, Emma Green, Aurélie Swalduz, Gilles Clapisson, Jean-Yves Blay, Etienne Brain, Etienne Giroux Leprieur, Frank de Kievit, C. Raynaud, Virginie Avrillon, Virginie Westeel, Isabelle Monnet, Xavier Quantin, Nathalie Hoog-Labouret, Julien Mazieres, Claire Tissot, Séverine Martinez, Radj Gervais, Clive Morris, Celine Mahier, Y. Loriot, Washington René Chumbi Flores, Sandra Ortiz-Cuaran, Séverine Neymarc, Nathalie Girerd-Chambaz, Maurice Pérol, Christelle Clément Duchene
Publikováno v:
Cancer Research. 78:1841-1841
Background: BRAF mutations occur in 2 to 3% of patients (pts) with non-small cell lung cancer (NSCLC). In these pts vemurafenib, a selective oral BRAF inhibitor is associated with a response rate (RR) of 42%, rising to 64% for combination treatment w
Autor:
Matt Smith, Jonathan Hinton, Katherine Baker-Neblett, Frank de Kievit, Karen Howarth, Sarah Smalley, Peter N. Dimitrov, Samuel Woodhouse, Davina Gale, Nathan Campbell, Mikidache Madi, Catherine Leroy, Colin Herd, James H. Clark, Vincent Plagnol, Michael P. Epstein, Nitzan Rosenfeld, Jamie Platt, Tim Forshew, Esther Musgrave-Brown, Greg Jones, Will Brennan, Stefanie Lensing, John Calaway
Publikováno v:
Cancer Research. 78:939-939
Circulating tumor DNA (ctDNA) analysis enables minimally invasive assessment of somatic genetic alterations for cancer patients. ctDNA analysis is quickly being incorporated into cancer care; notably in profiling patients' tumors to guide treatment d
Autor:
Sandra Ortiz-Cuaran, Aurélie Swalduz, Solène Marteau, Pierre Saintigny, Gilles Clapisson, Séverine Martinez, Maurice Pérol, David Pérol, Virginie Avrillon, Clive Morris, Laure Montane, Frank de Kievit, Karen Howarth, Emma Green
Publikováno v:
Journal of Clinical Oncology. 36:e21031-e21031
e21031Background: Therapeutic response in ALK+ NSCLC is driven by heterogeneous mechanisms of resistance. Liquid biopsy (LB) offers a non-invasive approach to study the tumor genomic landscape unde...