Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Frank Yeung"'
Autor:
Keenan A. Lacey, Sandra Gonzalez, Frank Yeung, Gregory Putzel, Magdalena Podkowik, Alejandro Pironti, Bo Shopsin, Ken Cadwell, Victor J. Torres
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common causes of hospital-acquired pneumonia. To better manage patients with MRSA pneumonia, we require a greater understanding of the host-pathogen interactions during in
Externí odkaz:
https://doaj.org/article/78baa33b38514ddba6a13b6964fd8838
Autor:
Frank Yeung, Cristina M. Ramírez, Pedro A. Mateos-Gomez, Alexandra Pinzaru, Giovanni Ceccarini, Shaheen Kabir, Carlos Fernández-Hernando, Agnel Sfeir
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 1847-1856 (2013)
The mammalian telomere-binding protein Rap1 was recently found to have additional nontelomeric functions, acting as a transcriptional cofactor and a regulator of the NF-κB pathway. Here, we assess the effect of disrupting mouse Rap1 in vivo and repo
Externí odkaz:
https://doaj.org/article/642a61259b3145258119bf8737bb6de1
Autor:
Zaoyan Wan, Site Li, Ping Chen, Frank Yeung, Zimin Nie, Yangang Liang, Yilin Wang, Ruozhu Feng, Zheming Wang, Xin Zhang, Wei Wang
Publikováno v:
Advanced Composites and Hybrid Materials. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5682fdfe693b66f5960b8c019eb411f6
https://doi.org/10.1007/s42114-023-00635-2
https://doi.org/10.1007/s42114-023-00635-2
Autor:
Kyung Ku Jang, Thomas Heaney, Mariya London, Yi Ding, Frank Yeung, Defne Ercelen, Ying-Han Chen, Jordan Axelrad, Sakteesh Gurunathan, A. Marijke Keestra-Gounder, Matthew E. Griffin, Howard C. Hang, Ken Cadwell
Publikováno v:
bioRxiv
SUMMARYLoss of antimicrobial proteins such as REG3 family members compromises the integrity of the intestinal barrier. Here, we demonstrate that overproduction of REG3 proteins can also be detrimental by reducing a protective species in the microbiot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe4686792053bbd80204d00da5a160b
https://doi.org/10.1101/2023.01.29.526128
https://doi.org/10.1101/2023.01.29.526128
An intestinal organoid–based platform that recreates susceptibility to T-cell–mediated tissue injury
Autor:
Eugene Rudensky, Jennifer Tsai, Sandra J. Hoffman, Victor J. Torres, David Hudesman, Chen Liu, John Bertin, Ken Cadwell, Thomas Heaney, Brad J. Geddes, Marcel R.M. van den Brink, Jordan E. Axelrad, Yu Matsuzawa-Ishimoto, Xiaomin Yao, Allison M. Beal, Frank Yeung, P'ng Loke, Yusuke Shono, Ashley M. Hine, Jessica A Neil, Samantha L. Schuster, Michael Cammer, Ying-Han Chen, Amina Lazrak, Erin E Zwack, M. Zahidunnabi Dewan, Katherine B Nichols
Publikováno v:
Blood. 135:2388-2401
A goal in precision medicine is to use patient-derived material to predict disease course and intervention outcomes. Here, we use mechanistic observations in a preclinical animal model to design an ex vivo platform that recreates genetic susceptibili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::166102d0480ab9564cf6dd57562155e4
https://doi.org/10.1182/blood.2019004116
https://doi.org/10.1182/blood.2019004116
Autor:
Eugene Rudensky, Ruliang Xu, Frank Yeung, Elisabeth Kernbauer, Amanda M. Marchiando, Patricia Martin, Samantha L. Schuster, Ken Cadwell
Publikováno v:
Nature microbiology
As a conserved pathway that lies at the intersection between host defense and cellular homeostasis, autophagy serves as a rheostat for immune reactions. In particular, autophagy suppresses excess type I interferon (IFN-I) production in response to vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68bd8d94cdbfb6c2666da62f5596b0f
https://doi.org/10.1038/s41564-018-0229-0
https://doi.org/10.1038/s41564-018-0229-0
Autor:
Alex Cronkite, Frank Yeung, P'ng Loke, Jian-Da Lin, Caroline McCauley, Andrea L. Graham, Ken Cadwell, Joseph C. Devlin, Charlotte Drake-Dunn, Ying-Han Chen, Kelly V. Ruggles, Christina Hansen, Jacqueline M. Leung
Publikováno v:
Cell Host Microbe
Summary The relative contributions of genetic and environmental factors to variation in immune responses are poorly understood. Here, we performed a phenotypic analysis of immunological parameters in laboratory mice carrying susceptibility genes impl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3d2809fa5221bb68fc828c119210ae
https://pubmed.ncbi.nlm.nih.gov/32407704
https://pubmed.ncbi.nlm.nih.gov/32407704
Autor:
Jian-Da Lin, Joseph C. Devlin, Andrea L. Graham, Ying-Han Chen, Ken Cadwell, Alex Cronkite, Frank Yeung, Jacqueline M. Leung, P'ng Loke, Bo Shopsin, Kelly V. Ruggles, Zac W. Stephens, Christina Hansen, June L. Round, Yi Fulmer, Charlotte Drake-Dunn, Caroline McCauley
Publikováno v:
Cell Host Microbe
Summary Free-living mammals, such as humans and wild mice, display heightened immune activation compared with artificially maintained laboratory mice. These differences are partially attributed to microbial exposure as laboratory mice infected with p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2d808b12af38a0a862f506d0090332
https://doi.org/10.1101/742387
https://doi.org/10.1101/742387
Autor:
Jian-Da Lin, Frank Yeung, P'ng Loke, Christina Hansen, Joseph C. Devlin, Ying-Han Chen, Caroline McCauley, Kelly V. Ruggles, Charlotte Drake-Dunn, Alex Cronkite, Andrea L. Graham, Jacqueline M. Leung, Ken Cadwell
SUMMARYThe relative contributions of genetic and environmental factors to variation in immune responses are still poorly understood. Here, we performed a deep phenotypic analysis of immunological parameters of laboratory mice released into an outdoor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c751f24bf602c2c8bf7a19fe24d600
Autor:
Jian-Da Lin, Frank Yeung, Cooper Devlin, Ying-Han Chen, Caroline Mccauley, Alex Cronkite, Jacqueline M. Leung, Andrea L. Graham, Ken H. Cadwell, P’ng Loke
Publikováno v:
The Journal of Immunology. 202:131.3-131.3
Current research on immunology are largely based on clean laboratory mice kept in specific pathogen free (SPF) environments. They have the advantage of being inbred, genetically homogeneous and can be manipulated genetically in disease models. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6f7484fc0057bdacf163b3032400fe3
https://doi.org/10.4049/jimmunol.202.supp.131.3
https://doi.org/10.4049/jimmunol.202.supp.131.3