Výsledky vyhledávání - "Frank X. Morris"

Synthesis and physical characterization of a P1 arginine combinatorial library, and its application to the determination of the substrate specificity of serine peptidases

Autor: Yi-Ping Liu, Russell C. Mauger, Philip D. Edwards, Anne M. Strimpler, Stephen T. Furlong, Frank X. Morris

Publikováno v: Bioorganic & Medicinal Chemistry. 10:3637-3647

Serine peptidases are a large, well-studied, and medically important class of peptidases. Despite the attention these enzymes have received, details concerning the substrate specificity of even some of the best known enzymes in this class are lacking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f5dbb2ea3909c803668e334f7ee785
https://doi.org/10.1016/s0968-0896(02)00174-8

Zobrazit plný text záznamu

Synthesis and enzymatic evaluation of a P1 arginine aminocoumarin substrate library for trypsin-like serine proteases

Autor: Mark Sylvester, Kevin M. Cottrell, Kara K. Pine, Russell C. Mauger, Clay W Scott, Stephen T. Furlong, Frank X. Morris, Philip D. Edwards

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:2291-2294

A method for the solid-phase synthesis of P1 arginine containing peptides via attachment of the arginine side-chain guanidine group is described. This procedure is applied to the preparation of a tetrapeptide, P1 arginine aminocoumarin PS-SCL. This l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2718938346fc20b89fcd65fe6195865
https://doi.org/10.1016/s0960-894x(00)00460-1

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání