Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Frank Welsch"'
Publikováno v:
Regulatory Toxicology and Pharmacology. 80:283-290
The potencies of resorcinol, 6-propylthiouracil (PTU) and methimazole (MMI) for inducing developmental toxicity and neurotoxicity were compared in pregnant rats, regarded as valid model for human thyroid toxicity. Profound differences on maternal thy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f0bb05ca13cc2e3649d0856f2599f0
https://doi.org/10.1016/j.yrtph.2016.06.019
https://doi.org/10.1016/j.yrtph.2016.06.019
Autor:
Frank Welsch
Publikováno v:
International Journal of Toxicology. 27:59-63
Medical case reports published in the 20th century over the course of several decades show that resorcinol caused reversible adverse effects on the human thyroid gland (TG) manifested as hypothyroidism. Affected patients had ulcerating leg varicositi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d75d2ad65f5c3146e061489bdce3820
https://doi.org/10.1080/10915810701876687
https://doi.org/10.1080/10915810701876687
Autor:
A James, Rochelle W. Tyl, Frank Welsch, John C. Seely, Patricia A. Fail, Melissa C. Marr, Christina B. Myers, Barbara A. Elswick
Publikováno v:
Journal of Applied Toxicology. 23:397-410
Under Office of Prevention, Pesticides and Toxic Substances draft guidelines, CD weanling F0 rats (30 of each gender per group) inhaled tertiary amyl methyl ether vapor at 0, 250, 1500 or 3000 ppm 5 days a week and 6 h a day for 10 weeks, with vagina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdb108a36d13627ee1bc31a08df241c1
https://doi.org/10.1002/jat.928
https://doi.org/10.1002/jat.928
Publikováno v:
Regulatory Toxicology and Pharmacology. 38:17-26
The Advisory Committee on Existing Chemicals (BUA) of the Federal Republic of Germany convened a panel with expertise in reproductive and developmental toxicology to evaluate the OECD Screening Tests 421 (Reproduction/Developmental Toxicity Screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304abcab2998720d04eb69be88cb4b4b
https://doi.org/10.1016/s0273-2300(03)00076-x
https://doi.org/10.1016/s0273-2300(03)00076-x
Autor:
Frank Welsch
Publikováno v:
European Journal of Obstetrics & Gynecology and Reproductive Biology. 106:88-91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::995ebf624f3e2e1f458abf290eab5cc1
https://doi.org/10.1016/s0301-2115(02)00274-9
https://doi.org/10.1016/s0301-2115(02)00274-9
Autor:
Rochelle W. Tyl, R. Arden James, Melissa C. Marr, Barbara A. Elswick, Frank Welsch, Christina B. Myers
Publikováno v:
Journal of Applied Toxicology. 23:387-395
This evaluation was part of a much more comprehensive testing program to characterize the mammalian toxicity potential of the gasoline oxygenator additive tertiary amyl methyl ether (TAME), and was initiated upon a regulatory agency mandate. A develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feea5a61d7fed738c4c2e1ec204a980a
https://doi.org/10.1002/jat.927
https://doi.org/10.1002/jat.927
Autor:
Rodney W. Snyder, Susan C. Maness, Timothy R. Fennell, Susan Sumner, Frank Welsch, Kevin W. Gaido
Publikováno v:
Toxicology and Applied Pharmacology. 168:225-234
Bisphenol A (BPA), which is used in the manufacture of polycarbonates, elicits weak estrogenic activity in in vitro and in vivo test systems. The objectives of this study were to compare the patterns of disposition of radioactivity in adult female F-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b40e4d2cfdc28134f370c85f113dd2
https://doi.org/10.1006/taap.2000.9051
https://doi.org/10.1006/taap.2000.9051
Autor:
Madhabananda Sar, Frank Welsch
Publikováno v:
Endocrinology. 140:963-971
Immunohistochemical localization of two estrogen receptor (ER) subtypes, ER beta and ER alpha, was performed in neonatal, early postnatal, immature, and adult rats to determine whether ER alpha and ER beta are differentially expressed in the ovary. E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c72210d35a325b05b91ec140c837ab
https://doi.org/10.1210/endo.140.2.6533
https://doi.org/10.1210/endo.140.2.6533
Publikováno v:
Teratology. 58:231-240
Cell death was analyzed in neurulating mouse embryos after in vivo doses of 2-methoxyethanol (2-ME) that produce anterior neural tube defects. Characterization of 2-ME-induced cell death was performed by evaluating: (1) vital fluorochrome staining in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::416bf54b65b3415bc0bda6af7f7d4c1a
https://doi.org/10.1002/(sici)1096-9926(199812)58:6<231::aid-tera4>3.0.co
https://doi.org/10.1002/(sici)1096-9926(199812)58:6<231::aid-tera4>3.0.co
Publikováno v:
Toxicology and Applied Pharmacology. 145:311-322
Physiologically based pharmacokinetic (PBPK) models have been developed in recent years to describe the disposition of xenobiotics during gestation. These models can account for the dynamics of physiologic changes associated with pregnancy and repres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e2ccf71f28328999873bbbb7ef6a06
https://doi.org/10.1006/taap.1997.8170
https://doi.org/10.1006/taap.1997.8170