Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Frank Weekers"'
1
One Fourth of Unplanned Transfers to a Higher Level of Care Are Associated With a Highly Preventable Adverse Event
Autor: Frank Weekers, Martijn Droogmans, Neree Claes, Marjan Vandersteen, Elke De Troy, Gaby Kox, Annemie Vlayen, Kristel Marquet, Arthur Vleugels, Ward Schrooten
Publikováno v: Critical care medicine
Critical Care Medicine
Supplemental Digital Content is available in the text.
Objective: The objectives of this study are to determine the prevalence and preventability of adverse events requiring an unplanned higher level of care, defined as an unplanned transfer to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd521339ddb311fa6f954af260c6530
https://doi.org/10.1097/ccm.0000000000000932
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2
A quality improvement initiative to reduce ventilator-associated pneumonia at a large regional hospital
Autor: Inge Cleeren, Frank Weekers, Koen Magerman, Kris Vanhaecht, Arthur Vleugels, Eric Zandijk
Publikováno v: International Journal of Care Pathways. 16:76-82
Ventilator-associated pneumonia (VAP) is the leading cause of death among hospital-acquired infections and prolongs time spent on the ventilator, length of intensive care unit (ICU) stay and length of hospital stay after discharge from the ICU. The v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1316a71082e2c3f5f3be94d8e0ace2f3
https://doi.org/10.1258/jicp.2012.012008
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3
Endocrine modifications and interventions during critical illness
Autor: Frank Weekers, Greet Van den Berghe
Publikováno v: Proceedings of the Nutrition Society. 63:443-450
The ongoing hypermetabolic response in patients with prolonged critical illness leads to the loss of lean tissue mass. Since the cachexia of prolonged illness is usually associated with low concentrations of anabolic hormones, hormonal intervention h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::806f92edd41cd5c7783e26bf628accd3
https://doi.org/10.1079/pns2004373
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4
Endocrine and Metabolic Effects of Growth Hormone (GH) Compared with GH-Releasing Peptide, Thyrotropin-Releasing Hormone, and Insulin Infusion in a Rabbit Model of Prolonged Critical Illness
Autor: Veerle Darras, Eric Van Herck, Greet Van den Berghe, Frank Weekers, Willy Coopmans, Johannes D. Veldhuis, Marina Michalaki
Publikováno v: Endocrinology. 145:205-213
Treatment with recombinant human GH (rhGH) increases the mortality of critical illness. We postulated that combined GH-releasing peptide-2 (GHRP-2), TRH, and insulin infusion is a less toxic anabolic strategy through a putative inability to overstimu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885f37176b1d97fe7a3a21adaf9ad57e
https://doi.org/10.1210/en.2003-1005
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5
The combined administration of GH-releasing peptide-2 (GHRP-2), TRH and GnRH to men with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with GHRP-2 alone
Autor: Frank Weekers, Cyril Y. Bowers, Robert C. Baxter, Ali Iranmanesh, Johannes D. Veldhuis, Pieter Wouters, Greet Van den Berghe, Roger Bouillon
Publikováno v: Clinical Endocrinology. 56:655-669
Objective Central hyposomatotrophism, hypothyroidism and hypogonadism are present concomitantly in men with prolonged critical illness. This study evaluated the impact of combined treatment with GH-releasing peptide-2 (GHRP-2), TRH and GnRH for 5 day
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57762b9a3f699d28ae58e4f5f60d9ad5
https://doi.org/10.1046/j.1365-2265.2002.01255.x
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6
A Novel in Vivo Rabbit Model of Hypercatabolic Critical Illness Reveals a Biphasic Neuroendocrine Stress Response
Autor: Cyril Y. Bowers, Greet Van den Berghe, Frank Weekers, Johannes D. Veldhuis, Willy Coopmans, Marina Michalaki, Erik Van Herck
Publikováno v: Endocrinology. 143:764-774
High doses of GH, used to induce anabolism in prolonged critically ill patients, unexpectedly increased mortality. To further explore underlying mechanisms, a valid animal model is needed. Such a model is presented in this study. Seven days after art
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ce8d18e93d96910163bef4f60f19e7
https://doi.org/10.1210/endo.143.3.8664
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7
Intensive Insulin Therapy in Critically Ill Patients
Autor: Roger Bouillon, Frank Weekers, Dirk Vlasselaers, Miet Schetz, Pieter Wouters, Patrick Ferdinande, Peter Lauwers, Greet Van den Berghe, Frans Bruyninckx, Charles Verwaest
Publikováno v: New England Journal of Medicine. 345:1359-1367
Hyperglycemia and insulin resistance are common in critically ill patients, even if they have not previously had diabetes. Whether the normalization of blood glucose levels with insulin therapy improves the prognosis for such patients is not known.We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe57109bd5e395f63c4899a9908177c0
https://doi.org/10.1056/nejmoa011300
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8
Pretreatment with Growth Hormone-Releasing Peptide-2 Directly Protects against the Diastolic Dysfunction of Myocardial Stunning in an Isolated, Blood-Perfused Rabbit Heart Model1
Autor: Frank Weekers, Greet Van den Berghe, Eric Van Herck, Jörgen Isgaard
Publikováno v: Endocrinology. 141:3993-3999
Brief coronary occlusion followed by reperfusion leads to reversible myocardial dysfunction (stunning) which can induce irreversible damage of other organ systems. We studied the effects of pretreatment with recombinant human GH (rhGH) and the GH-sec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2665a3d37741098d7dbf15afcb3aab8a
https://doi.org/10.1210/endo.141.11.7768
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9
A Paradoxical Gender Dissociation within the Growth Hormone/Insulin-Like Growth Factor I Axis during Protracted Critical Illness1
Autor: Frank Weekers, G Van den Berghe, Johannes D. Veldhuis, Pieter Wouters, Cyril Y. Bowers, Robert C. Baxter
Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 85:183-192
Female gender appears to protect against adverse outcome from prolonged critical illness, a condition characterized by blunted and disorderly GH secretion and impaired anabolism. As a sexual dimorphism in the GH secretory pattern of healthy humans an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed3ac2a9ed6b7df1048fd502b3af9020
https://doi.org/10.1210/jcem.85.1.6316
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10
Reactivation of Pituitary Hormone Release and Metabolic Improvement by Infusion of Growth Hormone-Releasing Peptide and Thyrotropin-Releasing Hormone in Patients with Protracted Critical Illness1
Autor: Johannes D. Veldhuis, Roger Bouillon, Subburaman Mohan, Cyril Y. Bowers, Greet Van den Berghe, Pieter Wouters, Frank Weekers, Robert C. Baxter
Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 84:1311-1323
Protracted critical illness is marked by protein wasting resistant to feeding, by accumulation of fat stores, and by suppressed pulsatile release of GH and TSH. We previously showed that the latter can be reactivated by brief infusion of GH-releasing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf76d80e0755848ac370dab116d944f6
https://doi.org/10.1210/jcem.84.4.5636
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