Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Frank W. Marcoux"'
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Recent advances in the treatment of melanoma that involve immunotherapy and B-Raf inhibition have revolutionised cancer care for this disease. However, an un-met clinical need remains in B-Raf inhibitor resistant patients where fi
Externí odkaz:
https://doaj.org/article/595c5659b7134552a9c0581e9e360ed4
Autor:
Frank W. Marcoux, Dennis W. Choi
'CNS neuroprotection'was a common subject of papers, symposia, and reviews during the previous'decade of the brain.'Indeed, in recent years, experimental study of putative neuroprotective agents prompted clinical trials of numerous drug candidates in
Autor:
Lydia Johns, R. Loch Macdonald, George Lin, Andrew Kowalczuk, Linda S. Marton, Hussein Hallak, Frank W. Marcoux
Publikováno v:
Neurologia medico-chirurgica. 38:138-145
This randomized, blinded study tested the prophylactic effect of PD156707, a nonpeptide competitive antagonist of endothelin A receptors, against vasospasm after subarachnoid hemorrhage in dogs. Twenty-two dogs were allocated on day 0 to undergo cere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5debe34c9d1c2224b99f38b6b76a9f98
https://doi.org/10.2176/nmc.38.suppl_138
https://doi.org/10.2176/nmc.38.suppl_138
Autor:
Albert W. Probert, Peter A. Boxer, SA Borosky, Kevin K.W. Wang, Linda L. Coughenour, Iradj Hajimohammadreza, Frank W. Marcoux
Publikováno v:
The Journal of Neuroscience. 15:4093-4101
Calcium/calmodulin-dependent protein kinase-II (CamK-II) is a major neuronal protein which plays a significant role in the cellular process of long-term potentiation (LTP), and vesicular release of neurotransmitters. Here, we show that KN-62, 1-[N,O-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e06f3297048e6b5ef7b9987ba74a7eb
https://doi.org/10.1523/jneurosci.15-05-04093.1995
https://doi.org/10.1523/jneurosci.15-05-04093.1995
Autor:
Thomas Charles Malone, Gregory W. Campbell, Elsebet Ø. Nielsen, Peter A. Boxer, Jorgen Drejer, Christopher F. Bigge, Frank Wätjen, Frank W. Marcoux, David M. Rock, Leif Helth Jensen, Leonard Joseph Lescosky, Linda L. Coughenour
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:371-376
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8c346721d74ca36cf753dffe53bc279
https://doi.org/10.1016/s0960-894x(01)80147-5
https://doi.org/10.1016/s0960-894x(01)80147-5
Publikováno v:
Neuropharmacology. 32:1351-1358
The effects of (1S,3R)-ACPD, a selective metabotropic glutamate receptor agonist, on NMDA-induced 45Ca2+ accumulation and delayed neuronal cell death were determined using primary cerebrocortical cultures. Exposure to (1S,3R)-ACPD alone, although cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056d97ff9ae7db377d1b77095cf4f4dc
https://doi.org/10.1016/0028-3908(93)90030-7
https://doi.org/10.1016/0028-3908(93)90030-7
Autor:
Leonard Joseph Lescosky, Peter A. Boxer, Christopher F. Bigge, E. Oe. Nielen, Thomas Charles Malone, David M. Rock, Gregory W. Campbell, Frank W. Marcoux, F. Waetjen, L. H. Jensen, J. Drejer, Linda L. Coughenour
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c38063053e43445d1cf35f12d1ae9f8
https://doi.org/10.1002/chin.199427105
https://doi.org/10.1002/chin.199427105
Autor:
Laura J. Brahce, Daniel F. Ortwine, Christopher F. Bigge, Daniel Martin Retz, Linda L. Coughenour, Frank W. Marcoux, Graham Johnson, Albert W. Probert, James T. Drummond
Publikováno v:
Journal of Medicinal Chemistry. 35:1371-1384
A series of N-substituted alpha-amino acids containing terminal phosphonic acid groups has been synthesized as potential N-methyl-D-aspartate (NMDA) receptor antagonists. NMDA receptor affinity was determined by displacement of a known ligand ([3H]CP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7c927f723ddcc8ca7e03127ecbe94d
https://doi.org/10.1021/jm00086a005
https://doi.org/10.1021/jm00086a005
Autor:
Lillian J. Robichaud, Frank W. Marcoux
Publikováno v:
Journal of Neurotrauma. 7:193-206
Transcranial cold injury in rats and guinea pigs induced cerebral extravasation of albumin labeled with Evans blue dye or 125I, respective indicators of the area and amount of blood-brain barrier (BBB) disruption. Radioimmunoassay of brain extracts s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9b81fc7f2d2cf4adc0da96a3579261
https://doi.org/10.1089/neu.1990.7.193
https://doi.org/10.1089/neu.1990.7.193
Autor:
Graham J. Birrell, Frank W. Marcoux
Publikováno v:
British journal of pharmacology. 109(2)
1. Characterization of excitatory amino acid-induced accumulation of [3H]-phosphoinositides was carried out in primary cerebrocortical cultures isolated from foetal rats. 2. All of the excitatory amino acid receptor agonists examined caused concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a03275e46354fda8ea5e864d9c5f8e3
https://pubmed.ncbi.nlm.nih.gov/8395285
https://pubmed.ncbi.nlm.nih.gov/8395285