Výsledky vyhledávání - "Frank W. Lee"

Proposed New Addition to 3Rs for Ethical and Humane Use of Rats in Pharmacokinetic Studies – ‘Recycle’

Autor: Chaung Lu, Ji Zhang, Suresh K. Balani, Frank W. Lee, Kym Cardoza, Cicely Berg

Publikováno v: Drug Metabolism Letters. 2:193-197

The great emphasis on ethical and humane treatment of animals in biomedical research has culminated in the promulgation of the rule of 3Rs - Replacement, Reduction, and Refinement. We have proposed an addition to the 3Rs - a fourth R for Recycling th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac0345331030a4cd749fed85102db9b2
https://doi.org/10.2174/187231208785425827

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Prediction of Pharmacokinetic Drug-Drug Interactions Using Human Hepatocyte Suspension in Plasma and Cytochrome P450 Phenotypic Data. II. In Vitro-in Vivo Correlation with Ketoconazole

Autor: Chuang, Lu, Panos, Hatsis, Cicely, Berg, Frank W, Lee, Suresh K, Balani

Publikováno v: Drug Metabolism and Disposition. 36:1255-1260

Traditional cytochrome P450 (P450) based drug-drug interaction (DDI) predictions are based on the ratio of an inhibitor's physiological concentration [I] and its inhibition constant K(i). Determining [I] at the enzymatic site, although critical for p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0848623515340c1dbc5ea7dc318e7a
https://doi.org/10.1124/dmd.107.018796

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Drug safety evaluation through biomarker analysis—A toxicity study in the cynomolgus monkey using an antibody-cytotoxic conjugate against ovarian cancer

Autor: Elizabeth Tengstrand, Lily Y. Li, Frank Y. Hsieh, Mark N. Milton, Bill Riordan, Gerald T. Miwa, Carl L. Alden, Frank W. Lee, Lee Silverman, Ju-Whei Lee

Publikováno v: Toxicology and Applied Pharmacology. 224:12-18

Antibody–cytotoxin conjugates are complex novel therapeutic agents whose toxicological properties are not presently well understood. The objective of this study was to identify serum biomarkers that correlate with MLN8866 (an Antibody-Cytotoxic Con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc751b3a324bc16ad58bdef238b37ec
https://doi.org/10.1016/j.taap.2007.06.009

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Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor α-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study

Autor: Kim L. R. Brouwer, Lauren E. Richards, Carl P. Decicco, Frank W. Lee, C. Edwin Garner, Hao Xiong, Gang Luo, Jingwu Duan, Thomas P. Maduskuie, Hanbo Hu, Liang Shang Gan, Helen Shen

Publikováno v: Drug Metabolism and Disposition. 35:835-840

DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] is a potent human tumor necrosis factor alpha-converting enzyme inhibitor with potential therapeutic implications for rheuma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3804ca05378ff71848e1b496e37d989f
https://doi.org/10.1124/dmd.106.013946

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Strategy of Utilizing In Vitro and In Vivo ADME Tools for Lead Optimization and Drug Candidate Selection

Autor: Suresh K. Balani, Liang-Shang Gan, Jing-Tao Wu, Gerald T. Miwa, Frank W. Lee

Publikováno v: Current Topics in Medicinal Chemistry. 5:1033-1038

The high-throughput screening in drug discovery for absorption, distribution, metabolism and excretion (ADME) properties has become the norm in the industry. Only a few years ago it was ADME properties that were attributed to more failure of drugs th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c64ead099c71c9d99f8dd7b8890f3d4
https://doi.org/10.2174/156802605774297038

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EFFECTIVE DOSING REGIMEN OF 1-AMINOBENZOTRIAZOLE FOR INHIBITION OF ANTIPYRINE CLEARANCE IN GUINEA PIGS AND MICE USING SERIAL SAMPLING

Autor: Liang-Shang Gan, Joanne Nguyen, Dun-Xue Mu, Suresh K. Balani, Jing-Tao Wu, Kym Cardoza, Hang Zeng, Frank W. Lee, Ping Li

Publikováno v: Drug Metabolism and Disposition. 32:1092-1095

Single-dose pharmacokinetics of 1-aminobenzotriazole (ABT), a potent nonspecific inhibitor of cytochromes P450 (P450s), were characterized after oral administration to mice and guinea pigs at doses of 50, 100, and 150 mg/kg using serial sampling in b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c65e5301f5295edeacb4763b132ab5a
https://doi.org/10.1124/dmd.104.000349

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Effective Dosing Regimen of 1-Aminobenzotriazole for Inhibition of Antipyrine Clearance in Rats, Dogs, and Monkeys

Autor: Bing He, Frank W. Lee, Tong Zhu, Suresh K. Balani, Tian J. Yang, Zhi Liu

Publikováno v: Drug Metabolism and Disposition. 30:1059-1062

1-Aminobenzotriazole (ABT) has been extensively used as a nonspecific inhibitor of cytochromes p450 (p450s) in animals for mechanistic studies, and antipyrine (AP) has been used as a probe for hepatic oxidative metabolic capacity determination in viv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22a87e5ed239a701ba7565d2eb48a91
https://doi.org/10.1124/dmd.30.10.1059

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