Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Frank W. Kotch"'
Autor:
Renée Procopio-Melino, Frank W. Kotch, Amar S. Prashad, Jose M. Gomes, Wenge Wang, Bo Arve, Andrew Dawdy, Lawrence Chen, Justin Sperry, Christine Hosselet, Tao He, Ronald Kriz, Laura Lin, Kimberly Marquette, Lioudmila Tchistiakova, Will Somers, Jason C. Rouse, Xiaotian Zhong
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Next-generation site-specific cysteine-based antibody–drug-conjugates (ADCs) broaden therapeutic index by precise drug-antibody attachments. However, manufacturing such ADCs for clinical validation requires complex full reduction and reoxi
Externí odkaz:
https://doaj.org/article/5cda877d16ac4d3e838e8490f8f4c4f8
Autor:
Weibin Chen, Thomas J. Porter, Robert E. Birdsall, Henry Shion, Frank W. Kotch, Reiko Iizuka, April Xu
Publikováno v:
YAKUGAKU ZASSHI. 137:525-528
Hydrophobic interaction chromatography (HIC) and MS are leading techniques for the characterization of the critical quality attributes (CQA) of antibody-drug conjugates (ADCs). This includes the average drug-to-antibody ratio (DAR) and drug loading d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2baf8da3fab64cc83a0dddaae82483d5
https://doi.org/10.1248/yakushi.16-00255-1
https://doi.org/10.1248/yakushi.16-00255-1
Publikováno v:
Organic Process Research & Development. 21:601-610
As antibody drug conjugates (ADCs) move through clinical development, from phase 1 to pivotal studies, supported by clinical efficacy and appropriate safety, the development of late stage and commercial-ready processes and methods becomes a priority.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::569c164ce1514a49d79015e81bb92b54
https://doi.org/10.1021/acs.oprd.7b00023
https://doi.org/10.1021/acs.oprd.7b00023
Publikováno v:
mAbs
Cysteine-conjugated antibody-drug conjugates (ADCs) are manufactured using controlled partial reduction and conjugation chemistry with drug payloads that typically occur in intervals of 0, 2, 4, 6, and 8. Control of heterogeneity is of particular imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd390f7b5d318bb3687390cacdf4de7
https://doi.org/10.1080/19420862.2015.1083665
https://doi.org/10.1080/19420862.2015.1083665
Autor:
Yun Ding, Mi Hee Ko, Shahriar Salamat, Yun Luo, Noël R. Peters, Luigi Puglielli, Frank W. Kotch, Mariana Pehar
Publikováno v:
The Journal of Biological Chemistry
Background: The acetyltransferases ATase1 and ATase2 regulate the levels of BACE1, which is involved in the pathogenesis of Alzheimer disease (AD). Results: Both ATases are up-regulated in the brain of AD patients. ATase1/ATase2 inhibitors were ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570a37d37b8af38d2cc84daf64f2f555
https://doi.org/10.1074/jbc.m111.310136
https://doi.org/10.1074/jbc.m111.310136
Autor:
Matthew Sung, Christine Hopf, Judy Lucas, Ken Geles, Jonathon Golas, Erik Upeslacis, Manoj Charati, Frank Loganzo, Hans-Peter Gerber, Kiran Khandke, Mark Kaplan, Puja Sapra, Frank W. Kotch, Edward Rosfjord
Publikováno v:
Cancer Research. 78:818-818
Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice and represent personalized murine ‘avatars' of those tumors. PDXs are valuable tumor models for drug development since they recapitulate the complexity of the human tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd8954117267a673b732e193e487a285
https://doi.org/10.1158/1538-7445.am2018-818
https://doi.org/10.1158/1538-7445.am2018-818
Publikováno v:
Protein Science. 16:208-215
Collagen is the most abundant protein in animals. Every third residue in a collagen strand is a glycine with phi, psi = -70 degrees, 175 degrees. A recent computational study suggested that replacing these glycine residues with D-alanine or D-serine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d74135fa52977e8dd08af6658ff65b
https://doi.org/10.1110/ps.062560107
https://doi.org/10.1110/ps.062560107
Publikováno v:
Biochemistry. 41:12133-12139
Nucleic acid quadruplexes are composed of guanine quartets stabilized by specific metal ions. X-ray diffraction can provide high-resolution information on the structure and metal binding properties of quadruplexes, but only if they can be crystallize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a1bda2ad6b982bd62742e09276ef46
https://doi.org/10.1021/bi020310p
https://doi.org/10.1021/bi020310p
Autor:
Galya Abdrakhmanova, Robert Mizani, Jeffery T. Davis, James C. Fettinger, Vladimir Sidorov, Frank W. Kotch
Publikováno v:
Journal of the American Chemical Society. 124:2267-2278
The ion transport activity of calix[4]arene tetrabutylamide 1,3-alt 2 was studied in liposomes, planar lipid bilayers, and HEK-293 cells. These experiments, when considered together with (1)H NMR and X-ray crystallography data, indicate that calix[4]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3797f297699428f85cca3e6024b96870
https://doi.org/10.1021/ja012338e
https://doi.org/10.1021/ja012338e
Publikováno v:
Organic Letters. 2:3277-3280
The lipophilic nucleoside, G 1, extracts Pb(2+) picrate from water into organic solvents to give structures based on the hydrogen-bonded G-quartet. Crystal structures indicate important differences between (G 1)(8)-Pb(2+) and (G 1)(8)-K(+). The dival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0703fc152ea603dfa277bed6f447166a
https://doi.org/10.1021/ol0065120
https://doi.org/10.1021/ol0065120