Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Frank W. Janssen"'
Publikováno v:
Toxicology and Applied Pharmacology. 59:355-363
Wy-13,876, 3-(p-chlorophenyl)-2,3-dihydro-3-hydroxythiazolo[3,2a]benzimidazole-2-acetic acid, causes enlargement of the thyroids of rats and dogs. Radioactivity was accumulated in the thyroids, but not in other tissues of dogs given the 14C-labeled d
Autor:
Dodda Leelavathi, Soong T. Chiang, Kenneth C. Lasseter, Frank W. Janssen, Eugene R. Fluck, Jerome A. Hubsher
Publikováno v:
The Journal of Clinical Pharmacology. 24:515-522
Twelve normal subjects each received single 300-, 600-, and 1200-mg oral doses of oxaprozin according to a three-period crossover design. Total drug plasma concentrations did not increase in proportion to the dose administered. Total clearance (CIo)
Publikováno v:
Agents and Actions. 12:211-215
Conventional dialysis cells were used in initial attempts to determine the binding characteristics of oxaprozin (4,5-diphenyl-2-oxazolepropionic acid, Wy-21,743). Equilibration required dialysis times up to 22 hours at 37 degrees C resulting in deter
Autor:
Hans W. Ruelius, Frank W. Janssen, Anthony J Coleman, Sandra K. Kirkman, Peter J Southgate, William J. Jusko, Soong T. Chiang
Publikováno v:
Clinical Pharmacology and Therapeutics. 27:352-362
Absorption, biotransformation, excretion, and kinetics of oxaprozin (4,5-diphenyl-2-oxazolepropionic acid) were examined in subjects after an oral dose of 14C-oxaprozin alone as well as before, during, and after long-term administration of unlabeled
Publikováno v:
Analytical Biochemistry. 30:217-221
A method for quantitation of cycloleucine in biological fluids is described. Cycloleucine is oxidized to cyclopentanone by ninhydrin. The cyclopentanone formed is extracted into chloroform and determined by GLC. The method is accurate, convenient, ra
Publikováno v:
Biochemical Pharmacology. 22:1379-1383
Publikováno v:
Biochemical and Biophysical Research Communications. 20:630-634
Autor:
Hans W. Ruelius, Frank W. Janssen
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Enzymology. 151:330-342
1. 1. A novel enzyme designated ‘alcohol oxidase’, has been isolated from the mycelium of a Basidiomycete belonging to the family Polyporaceae. In the presence of O2, this enzyme catalyzes the oxidation of the lower primary alcohols to the corres
Autor:
Frank W. Janssen, Hans W. Ruelius
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Enzymology. 167:501-510
1. 1. Carbohydrate oxidase, an enzyme obtained from the mycelium of the Basidiomycete Polyporus obtusus, has been shown to catalyze the oxidation of several carbohydrates at the second carbon atom to yield 2-keto products. The reactions catalyzed are
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Enzymology. 167:493-500
1. 1. Carbohydrate oxidase, an enzyme which catalyzes the oxidation of d-glucose, d-xylose, l-sorbose and δ-gluconolactone, thereby liberating H2O2, was isolated from the mycelium of the Basidiomycete Polyporus obtusus. 2. 2. The enzyme was purified