Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Frank Wätjen"'
1
Characterization of the Binding of [3H]NS 257, a Novel Competitive AMPA Receptor Antagonist, to Rat Brain Membranes and Brain Sections
Autor: Jorgen Drejer, Elsebet Ø. Nielsen, Frank Wätjen, Tina Holm Johansen
Publikováno v: Journal of Neurochemistry. 65:1264-1273
The binding of [ 3 H]NS 257 {1,2,3,6,7,8-hexahydro-3-(hydroxyimino)-N,N-[ 3 H]dimethyl-7-methyl-2-oxobenzo[2,1-b:3,4-c']dipyrrole-5-sulfonamide} to rat cortical membranes was characterized in the absence and presence of thiocyanate. Specific [ 3 H]NS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543e1aaf63326f33b900a66eedb567a1
https://doi.org/10.1046/j.1471-4159.1995.65031264.x
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3
A novel non-NMDA receptor antagonist shows selective displacement of low-affinity [3H]kainate binding
Autor: Elsebet Ø. Nielsen, Tina Holm Johansen, Jorgen Drejer, Frank Wätjen
Publikováno v: European journal of pharmacology. 246(3)
5-Nitro-6,7,8,9-tetrahydrobenzo[G]indole-2,3-dione-3-oxime (NS-102), a new competitive glutamate receptor antagonist displaced binding to non-N-methyl-D-aspartate (non-NMDA) binding sites with no activity at the NMDA and strychnine-insensitive glycin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa601976d5af73f90edfbb043f13549
https://pubmed.ncbi.nlm.nih.gov/8223944
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4
Isatin oximes - A novel series of bioavailable non-NMDA antagonists
Autor: Jorgen Drejer, Leif Helth Jensen, Elsebet Ø. Nielsen, Frank Wätjen
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:105-106
New isatin oximes are shown to be highly selective AMPA/kainate antagonists showing no antogonism of NMDA responses. In an AMPA seizure model in mice of the disclosed compounds has anticonvulsant effects both after i.v. and p.o. dosing.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51c11c25729f2f5f3b88fc4cefe32375
https://doi.org/10.1016/s0960-894x(00)80101-8
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6
Selective reactions of α-aryl wittig reagents with the formyl moiety of 4-formylbenzoyl chloride
Autor: Otto Dahl, Frank Wätjen, Ole Buchardt
Publikováno v: Tetrahedron Letters. 23:4741-4744
The benzylic Wittig reagents 2a, 2b and 2e react with 4-formylbenzoyl chloride 1 to give 40–60% yields of products 3 derived from selective attack at the formyl group of 1 ; The same selectivity is not found for the non-stabilized ylids 2c and 2d o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fdb0cf49b0a071fd7c490793f6bd6ab
https://doi.org/10.1016/s0040-4039(00)85702-0
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8
A revised structure of tyriverdin
Autor: Carsten Christophersen, O. Buchardt, Frank Wätjen, Uffe Anthoni
Publikováno v: Tetrahedron. 34:2779-2781
The structure of tyriverdin, a precursor of Tyrian purple, has been revised by comparison of data obtained from synthetic and naturally derived samples. Model studies with indigotin, the debromoanalogue, are described and it is shown that the light i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::974e6f4a888323ea1c79f67a07742b0b
https://doi.org/10.1016/0040-4020(78)88419-1
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9
NS 004--an activator of Ca(2+)-dependent K+ channels in cerebellar granule cells
Autor: Søren-Peter Olesen, Frank Wätjen, Ellen Munch, Jørgen Drejer
Publikováno v: Europe PubMed Central
The large-conductance Ca(2+)-dependent K+ channels or BK channels in cerebellar granule cells were studied by patch-clamp technique, and the effects on channel activity of the molecule NS 004 (1-(2-hydroxy-5-chlorophenyl)-5-trifluoromethyl-2- benzimi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bd5ef1e3857da0b8df9e69e968dffe
http://europepmc.org/abstract/med/7520298
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