Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Frank V. Leopardi"'
Autor:
Zachary W. Fitch, Paul M. Schroder, Jean Kwun, Miriam Manook, Mingqing Song, Andrew S. Barbas, Stuart J. Knechtle, Janghoon Yoon, Robin Schmitz, Frank V. Leopardi, Alton B. Farris, Brian Ezekian, Bradley H. Collins, Ashley Y. Choi
Publikováno v:
Kidney Int
Sensitized patients are difficult to transplant due to pre-formed anti-donor immunity. We have previously reported successful desensitization using carfilzomib and belatacept in a non-human primate (NHP) model. Here we evaluated selective blockade of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27364180a16aea4dcffd0cab6dcec60
https://pubmed.ncbi.nlm.nih.gov/32898569
https://pubmed.ncbi.nlm.nih.gov/32898569
Autor:
Mohamad M Ibrahim, Howard Levinson, David Ruppert, Richard R. Glisson, Frank V. Leopardi, Maragatha Kuchibhatla, Randall P. Reynolds, Thomas Risoli, Jeffrey I. Everitt, Jason L. Green
Publikováno v:
J Med Device
One opportunity to reduce hernia occurrence and recurrence rates (currently estimated to be 30% at 10 years postoperatively) is by enhancing the ability of hernia meshes to anchor into tissue to prevent mesh migration, mesh contraction, and mesh tear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9634fb5242b7b34e10bb4195467359e
https://doi.org/10.1115/1.4043740
https://doi.org/10.1115/1.4043740
Autor:
Allan D. Kirk, Robert Patrick Davis, Zachary W. Fitch, Mingqing Song, Gayathri R. Devi, Qimeng Gao, Xunrong Luo, Tam How, Kannan P. Samy, Frank V. Leopardi, Bradley H. Collins, Michael S. Mulvihill, Andrea L. MacDonald, K.D. Williams
Publikováno v:
Xenotransplantation
Background Membrane cofactor protein CD46 attenuates the complement cascade by facilitating cleavage of C3b and C4b. In solid organ xenotransplantation, organs expressing CD46 have been shown to resist hyperacute rejection. However, the incremental v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ac33a4b628f8958165e4a63530039b
https://pubmed.ncbi.nlm.nih.gov/31219218
https://pubmed.ncbi.nlm.nih.gov/31219218
Autor:
C. Burghuber, Alton B. Farris, Frances M. Saccoccio, Sallie R. Permar, Stuart J. Knechtle, Frank V. Leopardi, Jean Kwun, M. Song, Brian Ezekian, Adriana C Gibby, Miriam Manook, Jennifer A. Jenks, Neal N. Iwakoshi
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 19(3)
Previous evidence suggests that a homeostatic germinal center (GC) response may limit bortezomib desensitization therapy. We evaluated the combination of costimulation blockade with bortezomib in a sensitized non-human primate kidney transplant model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f3bd30dacc08bdb04c96208a1b473d
https://pubmed.ncbi.nlm.nih.gov/30102844
https://pubmed.ncbi.nlm.nih.gov/30102844
Autor:
M. Song, Steven J. Chapin, Denise Lo, Frank V. Leopardi, Allan D. Kirk, Erik E. Karrer, Bruce H. Devens, Elizabeth Strobert, Douglas J. Anderson, Alton B. Farris
Publikováno v:
American Journal of Transplantation. 15:984-992
Costimulation blockade with the B7-CD28 pathway-specific agent belatacept is now used in clinical kidney transplantation, but its efficacy remains imperfect. Numerous alternate costimulatory pathways have been proposed as targets to synergize with be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecba3c405492bc31bde3f4a6ae175b2d
https://doi.org/10.1111/ajt.13100
https://doi.org/10.1111/ajt.13100
Autor:
Francois Villinger, Adriana C Gibby, Andrew B. Adams, Jung Joo Hong, Neal N. Iwakoshi, Stuart J. Knechtle, Miriam Manook, Alton B. Farris, Jean Kwun, Frank V. Leopardi, M. Song, Eugenia J Page, C. Burghuber
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 16(6)
We have established a model of sensitization in nonhuman primates and tested two immunosuppressive regimens. Animals underwent fully mismatched skin transplantation, and donor-specific antibody (DSA) response was monitored by flow cross-match. Sensit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89de3a534355eade1064bbd59d5df561
https://pubmed.ncbi.nlm.nih.gov/26705099
https://pubmed.ncbi.nlm.nih.gov/26705099
Autor:
Frank V. Leopardi, Matthew F. Starost, Jonathan P. Pearl, Douglas A. Hale, He Xu, Edwin H. Preston, Kiran K. Dhanireddy, Allan D. Kirk
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 5(5)
CD154-specific antibody therapy prevents allograft rejection in many experimental transplant models. However, initial clinical transplant trials with anti-CD154 have been disappointing suggesting the need for as of yet undetermined adjuvant therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51a9a071c132405e5ebecf4ea88fd51
https://pubmed.ncbi.nlm.nih.gov/15816883
https://pubmed.ncbi.nlm.nih.gov/15816883
Autor:
He Xu, Allan D. Kirk, Xiaojie Zhang, Frank V. Leopardi, Kiran K. Dhanireddy, Douglas A. Hale, Lynt B. Johnson
Publikováno v:
Journal of the American College of Surgeons. 199:96-97
Introduction: Portal venous inoculation of alloantigen has been demonstrated to induce hyporesponsiveness in multiple rodent models and has been suggested as a preferred method of donor specific transfusion (DST) for human tolerance protocols. Portal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1da4a6c0b4c76b0ffb6c7c24a57f22f0
https://doi.org/10.1016/j.jamcollsurg.2004.05.213
https://doi.org/10.1016/j.jamcollsurg.2004.05.213
Autor:
Xiaojie Zhang, Sruti Shiva, Frank V. Leopardi, David A. Bruno, Mark T. Gladwin, Allan D. Kirk, Kiran K. Dhanireddy
Publikováno v:
Journal of the American College of Surgeons. 203:S31
METHODS: We designed a non-human primate renal ischemiareperfusion model to test the effects of nitrite in preserving renal function. Adult cynomologous monkeys were subjected to 30 minutes of bilateral warm renal ischemia with or without 1.8 umol/kg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17bf3d4d8e7c92d7743772d32f0eb33e
https://doi.org/10.1016/j.jamcollsurg.2006.05.076
https://doi.org/10.1016/j.jamcollsurg.2006.05.076
Autor:
Frank V. Leopardi, Lynt B. Johnson, David A. Bruno, Xiaojie Zhang, Allan D. Kirk, Kiran K. Dhanireddy
Publikováno v:
Journal of the American College of Surgeons. 203:S92
RT-1l recipient)were sensitized with whole blood 0.5cc IP. Total IgG/ IgM and DSA titers were analyzed by ELISA and flow cytometry, respectively. Orthotopic liver transplantation and heterotopic heart transplantation were performed using standard tec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4813ea607370e789dcc568e4b26ccc49
https://doi.org/10.1016/j.jamcollsurg.2006.05.240
https://doi.org/10.1016/j.jamcollsurg.2006.05.240