Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Frank U. Axe"'
Publikováno v:
Rapid Communications in Mass Spectrometry. 25:681-688
Gaseous metal anions such as Na(-), K(-), Cs(-), and Ag(-) can be generated at ambient temperatures by the collision-induced dissociation of the anions of several dicarboxylic acid salts, including oxalate, maleate, fumarate, succinate, and glutamate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fd930d4deb20c72aea24d4239955ac0
https://doi.org/10.1002/rcm.4913
https://doi.org/10.1002/rcm.4913
Autor:
Lars Karlsson, Neelakandha S. Mani, Todd K. Jones, Steven Nguyen, Pragnya J. Desai, Cheryl A. Grice, Kristen L. Arienti, Robin L. Thurmond, Frank U. Axe, James P. Edwards, Mike Randal, Siquan Sun, Danielle K. Wiener, Michael K. Ameriks, Jing Liu, Alice Lee-Dutra, Damara Gebauer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2370-2374
A series of pyrazole-based thioethers were prepared and found to be potent cathepsin S inhibitors. A crystal structure of 13 suggests that the thioether moiety may bind to the S3 pocket of the enzyme. Additional optimization led to the discovery of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c34a29a046072b572140132f3755f69
https://doi.org/10.1016/j.bmcl.2010.01.108
https://doi.org/10.1016/j.bmcl.2010.01.108
Publikováno v:
Organometallics. 29:724-731
The electronic structure of organometallic complexes with the phosphine analogue ligands trimethylarsine and trimethylstibine was studied. Four new complexes, CpMn(CO)2AsMe3, CpMn(CO)2SbMe3, Co(CO)...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96050d0a64ad60ee3b9531203818de21
https://doi.org/10.1021/om900351y
https://doi.org/10.1021/om900351y
Publikováno v:
International Journal of Quantum Chemistry. 36:199-209
Peroxidases are oxidative metabolizing heme proteins, whereas myoglobin (Mb) with the same heme active site, a protoporphyrin IX with a proximal histidine and a water as axial ligands, belongs to the “globin” heme protein family that functions as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bce54c457d4624c3f9dcbb67646a955e
https://doi.org/10.1002/qua.560360715
https://doi.org/10.1002/qua.560360715
Publikováno v:
Journal of Molecular Graphics and Modelling. 24:456-464
Molecular modeling was used to analyze the binding mode and activities of histamine H3 receptor antagonists. A model of the H3 receptor was constructed through homology modeling methods based on the crystal structure of bovine rhodopsin. Known H3 ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18df807ddfa00c9a777bc334e836389
https://doi.org/10.1016/j.jmgm.2005.10.005
https://doi.org/10.1016/j.jmgm.2005.10.005
Autor:
Anders Brunmark, Liming Huang, Kirsten L. Arienti, Kelly J. McClure, J. Guy Breitenbucher, Frank U. Axe, Jon Blevitt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1924-1928
In a recent paper, [Arienti, K. L.; Brunmark, A.; Axe, F. U.; McClure, K. M.; Lee, A.; Blevitt, J.; Neff, D. K.; Huang, L.; Crawford, S.; Chennagiri, R. P.; Karlsson, L.; Brietenbucher, J. G. J. Med. Chem.2005, 48, 1873], we described the discovery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fe9b2e1dadea11395cc5a094cc0c66
https://doi.org/10.1016/j.bmcl.2005.12.096
https://doi.org/10.1016/j.bmcl.2005.12.096
Checkpoint Kinase Inhibitors: SAR and Radioprotective Properties of a Series of 2-Arylbenzimidazoles
Autor:
Anders Brunmark, Danielle K. Neff, Shelby Crawford, Lars Karlsson, Kelly J. McClure, Alice Lee, J. Guy Breitenbucher, Chennagiri R. Pandit, Frank U. Axe, Kristen L. Arienti, Jon Blevitt, Liming Huang
Publikováno v:
Journal of Medicinal Chemistry. 48:1873-1885
The discovery of a series of novel, potent, and highly selective inhibitors of the DNA damage control kinase chk2 is disclosed. Here we report the first SAR study around inhibitors of this kinase. High-throughput screening of purified human chk2 led
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3df8e2ecf621defa959c85adfd13db8
https://doi.org/10.1021/jm0495935
https://doi.org/10.1021/jm0495935
Autor:
Karin Bach Møller, Niels Møller, Lars Fogh Iversen, Frank U. Axe, Anja K. Pedersen, Ole Hvilsted Olsen, Ida Katrine Lund, Michael J. Newman, Yu Ge, Henrik Sune Andersen, Daniel D. Holsworth
Publikováno v:
Journal of Biological Chemistry. 279:24226-24235
Protein-tyrosine phosphatases (PTPs) are considered important therapeutic targets because of their pivotal role as regulators of signal transduction and thus their implication in several human diseases such as diabetes, cancer, and autoimmunity. In p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32dc28ebde358d9c0d4f76afde8e960
https://doi.org/10.1074/jbc.m313027200
https://doi.org/10.1074/jbc.m313027200
Autor:
William Charles Ripka, Scott W. Nelson, Kevin M. Short, Michael J. Newman, Richard B. Honzatko, Karl Norvell, Frank U. Axe, Kristen L. Arienti, Deborah H. Slee, Tassie L. Collins, Todd K. Jones, Jun-young Choe, Herbert J. Fromm, Rachel Denise Anne Kimmich, Suzanne J. Romano
Publikováno v:
Journal of Biological Chemistry. 278:51176-51183
A highly constrained pseudo-tetrapeptide (OC252-324) further defines a new allosteric binding site located near the center of fructose-1,6-bisphosphatase. In a crystal structure, pairs of inhibitory molecules bind to opposite faces of the enzyme tetr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea24c33701eda690081ee60805f1970
https://doi.org/10.1074/jbc.m308396200
https://doi.org/10.1074/jbc.m308396200
Autor:
Frank U. Axe, Jan Andzelm
Publikováno v:
Journal of the American Chemical Society. 121:5396-5402
Local and nonlocal density functional theory (DFT) was used to study olefin metathesis in the TiCp2C3H4(R1,R2) system, in which the alkyl substituents (R1,R2) are at the β-position of the metallocyclobutane ring. The structures and stabilities of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::952c01a6f9d6f4207320d3e8ef06a9fb
https://doi.org/10.1021/ja980167g
https://doi.org/10.1021/ja980167g