Zobrazeno 1 - 10
of 2 273
pro vyhledávání: '"Frank U"'
Autor:
Fabian Frost, Stefan Weiss, Johannes Hertel, Malte Rühlemann, Corinna Bang, Andre Franke, Matthias Nauck, Marcus Dörr, Henry Völzke, Dirk Roggenbuck, Peter Schierack, Uwe Völker, Georg Homuth, Ali A. Aghdassi, Matthias Sendler, Markus M. Lerch, Frank U. Weiss
Publikováno v:
Gut Pathogens, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Antimicrobial autoantigenic glycoprotein 2 (GP2) is an important component of the innate immune system which originates from the exocrine pancreas as well as from the small intestines. The relationship of GP2 with the intestinal m
Externí odkaz:
https://doaj.org/article/c58f07de2a2f40068a82097d56140e30
Autor:
Fabian Frost, Valeria Khaimov, Volkmar Senz, Stefan Weiss, Bastian Klußmann-Fricke, Malte Rühlemann, Corinna Bang, Andre Franke, Tilman Pickartz, Christoph Budde, Ali A. Aghdassi, Stefan Siewert, Frank U. Weiss, Niels Grabow, Markus M. Lerch, Matthias Sendler
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundDevelopment of pancreatic necroses or pseudocysts are typical complications of pancreatitis and may require endoscopic drainage therapy using metal or plastic stents. Microbial infection of these lesions poses a major challenge. So far, the
Externí odkaz:
https://doaj.org/article/a53b2c32f88842aca6196cc54f962ef6
Autor:
Julius R. Herting, Jule H. König, Katarina Hadova, Alexander Heinick, Frank U. Müller, Paul Pauls, Matthias D. Seidl, Carolina Soppa, Uwe Kirchhefer
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundThe activity, localization, and substrate specificity of the protein phosphatase 2A (PP2A) heterotrimer are controlled by various regulatory B subunits. PR72 belongs to the B'' gene family and has been shown to be upregulated in human heart
Externí odkaz:
https://doaj.org/article/0391b36d90b2486bb1c37216f3917b3b
Autor:
Juliane Glaubitz, Anika Wilden, Janine Golchert, Georg Homuth, Uwe Völker, Barbara M. Bröker, Thomas Thiele, Markus M. Lerch, Julia Mayerle, Ali A. Aghdassi, Frank U. Weiss, Matthias Sendler
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
The function of T regulatory cells in the tissue fibrosis in chronic pancreatitis is not fully understood. Here the authors use a mouse model of chronic pancreatitis to show that Treg cells reduce IL-4 mediated chronic inflammation in the pancreas as
Externí odkaz:
https://doaj.org/article/332d0ba357ad49519705c0efff46dce0
Autor:
Julius R. Herting, Anna M. Berg, Katarina Hadova, Alexander Heinick, Simone König, Michael Kuhlmann, Frank U. Müller, Uwe Kirchhefer
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 3, Iss , Pp 100030- (2023)
Protein phosphatase 2A (PP2A) plays a central role in myocardial ischemia-reperfusion (I/R) injury. Several studies showed a detrimental function of PP2A by using either overexpression models of the catalytic subunit (PP2Ac) or exogenous inhibitors o
Externí odkaz:
https://doaj.org/article/5d5599b4e278488591046593677070c4
Autor:
Nils Bögeholz, Vincent Knappe, Paul Pauls, Jan S. Schulte, Joshua I. Goldhaber, Frank U. Müller, Georg Nickenig, Lars Eckardt, Jan W. Schrickel, Thomas Beiert
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 44, Iss , Pp 101168- (2023)
Aims: Na+/Ca2+ exchanger (NCX) upregulation in cardiac diseases like heart failure promotes as an independent proarrhythmic factor early and delayed afterdepolarizations (EADs/DADs) on the single cell level. Consequently, NCX inhibition protects agai
Externí odkaz:
https://doaj.org/article/0c3b1083b3bb430fa0b58ed94c2d0e29
Autor:
Fabian Frost, Tim Kacprowski, Malte Rühlemann, Stefan Weiss, Corinna Bang, Andre Franke, Maik Pietzner, Ali A. Aghdassi, Matthias Sendler, Uwe Völker, Henry Völzke, Julia Mayerle, Frank U. Weiss, Georg Homuth, Markus M. Lerch
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Gallstone disease affects up to twenty percent of the population in western countries and is a significant contributor to morbidity and health care expenditure. Intestinal microbiota have variously been implicated as either contributing to g
Externí odkaz:
https://doaj.org/article/475fbfa266654d25ba6d1a4c3a5fb3e3
Publikováno v:
Applied Sciences, Vol 13, Iss 3, p 1448 (2023)
This study presents an approach with a simple structure, low complexity and low costs to evaluate the real-time status and localize the faults of a smart PV system at module level based on field conditions. The performance evaluation approach of a PV
Externí odkaz:
https://doaj.org/article/23f08165c3b44e3c8ae05c570f8e88bf
Autor:
Paula Bollmann, Franziska Werner, Marko Jaron, Tom A. Bruns, Hartmut Wache, Jochen Runte, Peter Boknik, Uwe Kirchhefer, Frank U. Müller, Igor B. Buchwalow, Sven Rothemund, Joachim Neumann, Ulrich Gergs
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
As part of our ongoing studies on the potential pathophysiological role of serine/threonine phosphatases (PP) in the mammalian heart, we have generated mice with cardiac-specific overexpression of PP2Cβ (PP2C-TG) and compared them with littermate wi
Externí odkaz:
https://doaj.org/article/b021743755d641a393a09eb53a4cce6f
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 23 (2020)
BACKGROUND Transgenic mice (TG) with heart‐directed overexpresion of the isoform of the transcription factor cyclic adenosine monophosphate response element modulator (CREM), CREM‐IbΔC‐X, display spontaneous atrial fibrillation (AF) and action
Externí odkaz:
https://doaj.org/article/f5c5423e17954e17af07d2791ae9a1ff