Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Frank Tufaro"'
Autor:
Michael A. Vogelbaum, Farshad Nassiri, Clark C. Chen, Frank Tufaro, Shirley Ong, Adam M. Sonabend, Rohan Ramakrishna, Priya Kumthekar, Frederick Lang, Morris D. Groves, Barry Watkins, Gelareh Zadeh, Howard Colman, Carin Bidwell, Robert Aiken, Simon Khagi, Joanna Peterkin, Timothy F. Cloughesy, Laura Agensky, Mariza Daras
Publikováno v:
Neuro Oncol
BACKGROUND DNX-2401 (tasadenoturev) is a replication-competent, tumor-selective, oncolytic adenovirus. Phase I studies in adults with recurrent glioblastoma (rGBM) have demonstrated safety and encouraging clinical activity. A Phase II open-label, dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9729a46d32e41f44d380b45a4f07fb2f
https://europepmc.org/articles/PMC6847955/
https://europepmc.org/articles/PMC6847955/
Autor:
Jeffrey S. Weinberg, Candelaria Gomez-Manzano, Gregory N. Fuller, Ignacio I. Wistuba, Marta M. Alonso, Juan Fueyo, Jaime Rodriguez-Canales, Pamela Villalobos, Brett Ewald, Joanna Peterkin, Joy Gumin, Sonia Tejada, Frederick F. Lang, Frank Tufaro, Sujit S. Prabhu, Kenneth Aldape, W. K. Alfred Yung, Raymond Sawaya, Charles A. Conrad, Ganesh Rao, Luis M Vence, Ricardo Diez Valle, Clemens M F Dirven
Publikováno v:
Journal of Clinical Oncology, 36(14), 1419-+. American Society of Clinical Oncology
Purpose DNX-2401 (Delta-24-RGD; tasadenoturev) is a tumor-selective, replication-competent oncolytic adenovirus. Preclinical studies demonstrated antiglioma efficacy, but the effects and mechanisms of action have not been evaluated in patients. Metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f5333c43dedf1afe1c31a308b8adb3
https://pure.eur.nl/en/publications/2a13b671-0426-4a5f-9799-7a31c269a2dd
https://pure.eur.nl/en/publications/2a13b671-0426-4a5f-9799-7a31c269a2dd
Autor:
Brett Ewald, Karen Gammon, Farshad Nassiri, L Sue Frederick, Morris D. Groves, Sheila Fulling, Shirley Ong, Joanna Peterkin, Frederick Lang, Frank Tufaro, Kari Anne Rowland, Timothy F. Cloughesy, Michael A. Vogelbaum, Rohan Ramakrishna, Howard Colman, Erin Mitchell, Mariza Daras, Gelareh Zadeh
Publikováno v:
Neuro-Oncology. 20:vi6-vi6
BACKGROUND: DNX-2401 (tasadenoturev) is a replication-competent, tumor-selective, oncolytic adenovirus. A dose-escalating, Phase II study of a single intratumoral injection of DNX-2401 with pembrolizumab to determine optimal dose, safety and efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4f20817853226bd88e09ded2732b14
https://doi.org/10.1093/neuonc/noy148.019
https://doi.org/10.1093/neuonc/noy148.019
Autor:
Tomas Bergström, Tomomi Izumikawa, Hiroshi Kitagawa, Kazuyuki Sugahara, Toru Uyama, Miho Ishida, Frank Tufaro, Edward Trybala
Publikováno v:
Journal of Biological Chemistry. 281:38668-38674
We have demonstrated a defect in expression of chondroitin 4-O-sulfotransferase-1 (C4ST-1) in murine sog9 cells, which are poorly sensitive to infection by herpes simplex virus type 1 (HSV-1). Sog9 cells were previously isolated as CS-deficient cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e372e8119b4ed3c33ddd4713ec3e097f
https://doi.org/10.1074/jbc.m609320200
https://doi.org/10.1074/jbc.m609320200
Autor:
F. Lang, Paloma Villalobos, Marta M. Alonso, Candelaria Gomez-Manzano, Ricardo Diez Valle, Juan Fueyo, Brett Ewald, Ignacio I. Wistuba, Jaime Rodriguez-Canales, Kenneth R. Hess, Sonia Tejada, Frank Tufaro
Publikováno v:
Neuro-Oncology. 19:vi27-vi27
As part of a phase 1, dose-escalation, biological-endpoint clinical study (NCT00805376) of DNX-2401 (Delta-24-RGD), a Rb-targeted, tumor-selective, replication-competent oncolytic adenovirus, conducted in 37 patients with recurrent malignant glioma,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc31e2fa82ec867b217ea1c7c4330a1
https://doi.org/10.1093/neuonc/nox168.104
https://doi.org/10.1093/neuonc/nox168.104
Autor:
Juan Fueyo, Barbara Mino, Pamela Villalobos, Jaime Rodriguez-Canales, Marta M. Alonso, Ricardo Díez-Valle, Ignacio I. Wistuba, Candelaria Gomez-Manzano, Kenneth R. Hess, Sonia Tejada, Frank Tufaro, Frederick Lang, Brett Ewald
Publikováno v:
Cancer Research. 77:LB-235
T cell exhaustion is a key mechanism of tumor immune suppression and is commonly observed in several cancers. The exhausted T cells in the tumor microenvironment overexpress inhibitory receptors, show decreased effector cytokine production, and exhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3700281ff6ec4d151630089dbf4d75e2
https://doi.org/10.1158/1538-7445.am2017-lb-235
https://doi.org/10.1158/1538-7445.am2017-lb-235
Autor:
Candelaria Gomez-Manzano, Frederick Lang, Frank Tufaro, Charles A. Conrad, W. K. Alfred Yung, Juan Fueyo
BACKGROUND: Accumulating evidence has demonstrated that the immune system can recognize the antigenic changes in cancer cells, and further develop autoantibodies against these tumor-associated antigens (TAAs). Therefore, these cancer-associated autoa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d36b7ae02bfbb6305d250a7498a089e
https://europepmc.org/articles/PMC4144616/
https://europepmc.org/articles/PMC4144616/
Autor:
Carol-Ann Saari, Susan S. Chen, Qian-Jin Zhang, Maria G. Massuci, Frank Tufaro, Wilfred A. Jefferies
Publikováno v:
The Journal of Immunology. 164:4513-4521
Recent advances in clarifying the molecular mechanisms involved in Ag processing and presentation have relied heavily on the use of somatic cell mutants deficient in proteasome subunits, TAP transporter, and cell surface expression of MHC class I mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa69012b9d7220a9452523619bdf654
https://doi.org/10.4049/jimmunol.164.9.4513
https://doi.org/10.4049/jimmunol.164.9.4513
Autor:
Frank Tufaro, Sonia N. Yeung
Publikováno v:
Expert Opinion on Pharmacotherapy. 1:623-631
Attenuated viral vectors based on herpes simplex virus (HSV) are capable of killing cancer cells directly while sparing normal tissue in animal models of disease. This selective ability is likely due to the evolutionary constraints on the virus to es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f81d1762c5690dd5ad2630f205a539bd
https://doi.org/10.1517/14656566.1.4.623
https://doi.org/10.1517/14656566.1.4.623
Autor:
Virginia Booth, Zheng Chen, Paul L. Kaufman, Jiren Tan, William Jia, B'Ann T. Gabelt, Max S. Cynader, Frank Tufaro
Publikováno v:
Survey of Ophthalmology. 43:S91-S97
Gene therapy in the anterior and posterior segment tissues may have the potential to favorably influence aqueous hydrodynamics and retinal ganglion cell biology, thereby preventing, delaying, or minimizing glaucomatous damage to the optic nerve. We d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4cef4c3079803fcf1286777e55d5a2e
https://doi.org/10.1016/s0039-6257(99)00028-4
https://doi.org/10.1016/s0039-6257(99)00028-4