Výsledky vyhledávání - "Frank Sirotnak"

Microarray analysis of prostate cancer progression to reduced androgen dependence: Studies in unique models contrasts early and late molecular events

Autor: Yuhong She, Paula Hayes, Howard I. Scher, William Gerald, Nushmia Z. Khokhar, Frank Sirotnak

Publikováno v: Molecular Carcinogenesis. 41:150-163

Three unique variants of the CWR22 human prostate cancer xenograft model (CWR22LD1, LD2, and LD3) with a decrease in dependence on androgens were selected under noncastrate conditions, i.e., by outgrowth after transplantation into male NCR (AT) nu mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa8e2b7249db47f817ece67e95fb76b
https://doi.org/10.1002/mc.20051

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Activity of a Novel Anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against Human Lymphoma is Superior to Methotrexate and Correlates with Tumor RFC-1 Gene Expression

Autor: Owen A. O'Connor, Andrew D. Zelenetz, Eunice S. Wang, Frank Sirotnak, Malcolm A.S. Moore, Yuhong She

Publikováno v: Leukemia & Lymphoma. 44:1027-1035

PDX (10-propargyl-10-deazaaminopterin) is a novel anti-folate with improved membrane transport and polyglutamylation in tumor cells. In prior studies, PDX exhibited enhanced efficacy over methotrexate (MTX) in lung and breast carcinoma xenografts. Be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55b557ac2d576139cd3dd8dd22d4d5c
https://doi.org/10.1080/1042819031000077124

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Molecular cloning of the murine cMOAT ATPase

Autor: Frank Sirotnak, Friederike Fritz, Paula Hayes, Jing Chen

Publikováno v: Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1492:531-536

cMOAT encodes an ATPase within the family of cMOAT/MRP ATPases that functions as an ATP dependent, multispecific anion transporter within the canalicular surface of hepatocytes that has pharmacologic significance. We describe here the cloning of a mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2bf5e3992364c63802cb64d6912346c
https://doi.org/10.1016/s0167-4781(00)00132-9

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Facilitated transport of methotrexate polyglutamates into lysosomes derived from S180 cells. Further characterization and evidence for a simple mobile carrier system with broad specificity for homo- or heteropeptides bearing a C-terminal glutamyl moiety

Autor: D F O'Leary, Frank Sirotnak, J R Barrueco

Publikováno v: Journal of Biological Chemistry. 267:19986-19991

Studies are presented further characterizing a facilitative system transporting methotrexate (MTX) polyglutamates into lysosomes derived from S180 cells. Initial influx of [3H]MTX + G1 (MTX with 1 additional glutamyl residue) exhibited a slightly alk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab3739b347d89ce64f4cb4d0ec9e9e6b
https://doi.org/10.1016/s0021-9258(19)88654-4

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Metabolic turnover of methotrexate polyglutamates in lysosomes derived from S180 cells. Definition of a two-step process limited by mediated lysosomal permeation of polyglutamates and activating reduced sulfhydryl compounds

Autor: Frank Sirotnak, D F O'Leary, J R Barrueco

Publikováno v: Journal of Biological Chemistry. 267:15356-15361

Transport and metabolic turnover of methotrexate (MTX) polyglutamates were examined in lysosomes derived from S180 cells. These studies extend prior work from this laboratory (Barrueco, J. R., and Sirotnak, F. M. (1991) J. Biol. Chem 266, 11732-11737

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4d97a72df13aeefbed58587672e9104
https://doi.org/10.1016/s0021-9258(19)49541-0

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Energy-dependent efflux of methotrexate in L1210 leukemia cells. Evidence for the role of an ATPase obtained with inside-out plasma membrane vesicles

Autor: Scott R. Schlemmer, Frank Sirotnak

Publikováno v: Journal of Biological Chemistry. 267:14746-14752

Earlier studies from our laboratory (Dembo, M., Sirotnak F. M., and Moccio, D. M. (1984) J. Membr. Biol. 78, 9-17) suggested that methotrexate (MTX) efflux from L1210 cells was mediated predominantly by an ATP-dependent, outwardly directed, mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80f5356f6c3367c6e64850fa1deb4695
https://doi.org/10.1016/s0021-9258(18)42103-5

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A population pharmacokinetic and pharmacodynamic evaluation of pralatrexate in patients with relapsed or refractory non-Hodgkin's or Hodgkin's lymphoma

Autor: Michael Saunders, K Sweeney, Paul A. Hamlin, Ellen Neylon, Steven M. Horwitz, Frank Sirotnak, Martin Fleisher, Owen A. O'Connor, Diane R. Mould, Stephen B. Duffull

Publikováno v: Clinical pharmacology and therapeutics. 86(2)

In a pralatrexate phase I study, patients displayed a high incidence of mucositis of grades 3 and 4. Preliminary evaluations of the pharmacokinetics of the drug and its association with mucositis suggested that pralatrexate exposure (area under the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b83bfd7900b1591da129741068fce4
https://pubmed.ncbi.nlm.nih.gov/19474785

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