Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Frank Sinner"'
Autor:
Sabrina Schroeder, Sebastian J. Hofer, Andreas Zimmermann, Raimund Pechlaner, Christopher Dammbrueck, Tobias Pendl, G. Mark Marcello, Viktoria Pogatschnigg, Martina Bergmann, Melanie Müller, Verena Gschiel, Selena Ristic, Jelena Tadic, Keiko Iwata, Gesa Richter, Aitak Farzi, Muammer Üçal, Ute Schäfer, Michael Poglitsch, Philipp Royer, Ronald Mekis, Marlene Agreiter, Regine C. Tölle, Péter Sótonyi, Johann Willeit, Barbara Mairhofer, Helga Niederkofler, Irmgard Pallhuber, Gregorio Rungger, Herbert Tilg, Michaela Defrancesco, Josef Marksteiner, Frank Sinner, Christoph Magnes, Thomas R. Pieber, Peter Holzer, Guido Kroemer, Didac Carmona-Gutierrez, Luca Scorrano, Jörn Dengjel, Tobias Madl, Simon Sedej, Stephan J. Sigrist, Bence Rácz, Stefan Kiechl, Tobias Eisenberg, Frank Madeo
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108985- (2021)
Summary: Decreased cognitive performance is a hallmark of brain aging, but the underlying mechanisms and potential therapeutic avenues remain poorly understood. Recent studies have revealed health-protective and lifespan-extending effects of dietary
Externí odkaz:
https://doaj.org/article/39e2c2e4dbb64f9d873d1cd5180f9ef8
Autor:
Cornelia Pipper, Natalie Bordag, Bernadette Reiter, Kyriakos Economides, Peter Florian, Thomas Birngruber, Frank Sinner, Manfred Bodenlenz, Anita Eberl
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 758-766 (2019)
Eicosanoids are lipid-mediator molecules with key roles in inflammatory skin diseases, such as psoriasis. Eicosanoids are released close to the source of inflammation, where they elicit local pleiotropic effects and dysregulations. Monitoring inflamm
Externí odkaz:
https://doaj.org/article/15683cadfcbc49c7a16f002272bc6c20
Autor:
Didac Carmona-Gutierrez, Andreas Zimmermann, Katharina Kainz, Federico Pietrocola, Guo Chen, Silvia Maglioni, Alfonso Schiavi, Jihoon Nah, Sara Mertel, Christine B. Beuschel, Francesca Castoldi, Valentina Sica, Gert Trausinger, Reingard Raml, Cornelia Sommer, Sabrina Schroeder, Sebastian J. Hofer, Maria A. Bauer, Tobias Pendl, Jelena Tadic, Christopher Dammbrueck, Zehan Hu, Christoph Ruckenstuhl, Tobias Eisenberg, Sylvere Durand, Noélie Bossut, Fanny Aprahamian, Mahmoud Abdellatif, Simon Sedej, David P. Enot, Heimo Wolinski, Jörn Dengjel, Oliver Kepp, Christoph Magnes, Frank Sinner, Thomas R. Pieber, Junichi Sadoshima, Natascia Ventura, Stephan J. Sigrist, Guido Kroemer, Frank Madeo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Although ageing is the most important risk factor for chronic ailments, effective interventions remain rare. Here, the authors identify the flavonoid 4,4’-dimethoxychalcone and demonstrate that it extends lifespan and promotes health in multiple or
Externí odkaz:
https://doaj.org/article/5a077fc79ab04bd9a229474d374a66e5
Autor:
Angela Libiseller, Julia Kopanz, Katharina M. Lichtenegger, Julia K. Mader, Thomas Truskaller, Bettina Lackner, Felix Aberer, Marlene Pandis, Johanna Reinisch-Gratzer, Gisela C. Ambrosch, Frank Sinner, Thomas R. Pieber, Klaus Donsa
Publikováno v:
Contemporary Clinical Trials Communications, Vol 19, Iss , Pp 100620- (2020)
Introduction: Diabetes management can be especially complex for older adults who receive health care at home. Thus, international guidelines recommend basal-insulin regimens due to simpler handling and low hypoglycaemia risk. A basal-insulin algorith
Externí odkaz:
https://doaj.org/article/e064345650d84a5bbb269c311fc14e6d
Autor:
Ralf J. Braun, Cornelia Sommer, Christine Leibiger, Romina J.G. Gentier, Verónica I. Dumit, Katrin Paduch, Tobias Eisenberg, Lukas Habernig, Gert Trausinger, Christoph Magnes, Thomas Pieber, Frank Sinner, Jörn Dengjel, Fred W. van Leeuwen, Guido Kroemer, Frank Madeo
Publikováno v:
Cell Reports, Vol 10, Iss 9, Pp 1557-1571 (2015)
Neuronal accumulation of UBB+1, a frameshift variant of ubiquitin B, is a hallmark of Alzheimer’s disease (AD). How UBB+1 contributes to neuronal dysfunction remains elusive. Here, we show that in brain regions of AD patients with neurofibrillary t
Externí odkaz:
https://doaj.org/article/82827895d6f54a068f30299b67cf92a1
Autor:
Ralf J. Braun, Cornelia Sommer, Christine Leibiger, Romina J.G. Gentier, Verónica I. Dumit, Katrin Paduch, Tobias Eisenberg, Lukas Habernig, Gert Trausinger, Christoph Magnes, Thomas Pieber, Frank Sinner, Jörn Dengjel, Fred W. van Leeuwen, Guido Kroemer, Frank Madeo
Publikováno v:
Microbial Cell, Vol 2, Iss 4, Pp 136-138 (2015)
Impaired protein degradation and mitochondrial dysfunction are believed to contribute to neurodegenerative disorders, including Alzheimer disease (AD). In patients suffering from non-hereditary AD, UBB+1, the frameshift variant of ubiquitin B, accumu
Externí odkaz:
https://doaj.org/article/d3db5e16de364cd0aa782086fbc8062a
Autor:
Christoph Ruckenstuhl, Christine Netzberger, Iryna Entfellner, Didac Carmona-Gutierrez, Thomas Kickenweiz, Slaven Stekovic, Christina Gleixner, Christian Schmid, Lisa Klug, Ivan Hajnal, Alice G. Sorgo, Tobias Eisenberg, Sabrina Büttner, Guillermo Marino, Rafal Koziel, Christoph Magnes, Frank Sinner, Thomas R. Pieber, Pidder Jansen-Dürr, Kai-Uwe Fröhlich, Guido Kroemer, Frank Madeo
Publikováno v:
Microbial Cell, Vol 1, Iss 5, Pp 160-162 (2014)
Methionine restriction (MetR) is one of the rare regimes that prolongs lifespan across species barriers. Using a yeast model, we recently demonstrated that this lifespan extension is promoted by autophagy, which in turn requires vacuolar acidificatio
Externí odkaz:
https://doaj.org/article/bc3239da4039470eab23fab7b489917e
Autor:
Arijit Ghosh, Thomas Birngruber, Wolfgang Sattler, Thomas Kroath, Maria Ratzer, Frank Sinner, Thomas R Pieber
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98143 (2014)
Blood-brain barrier (BBB) impairment in systemic inflammation leads to neuroinflammation. Several factors including cytokines, chemokines and signal transduction molecules are implicated in BBB dysfunction in response to systemic inflammation. Here,
Externí odkaz:
https://doaj.org/article/b6d65f7b64154911be7fb61882269806
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20719 (2011)
Immune challenge by bacterial lipopolysaccharide (LPS) causes short-term behavioral changes indicative of depression. The present study sought to explore whether LPS is able to induce long-term changes in depression-related behavior and whether such
Externí odkaz:
https://doaj.org/article/22131f52d334450f839f7b5b8b398928
Autor:
Joanna Hummer, Thomas Birngruber, Frank Sinner, Leanne Page, Frank Toner, Clive S. Roper, David J. Moore, Mark B. Baker, Mila Boncheva Bettex
Publikováno v:
International journal of pharmaceutics. 620
This paper describes a new approach to the early-stage optimization of topical products and selection of lead formulation candidates. It demonstrates the application of open flow microperfusion in vitro in conjunction with the Franz diffusion cell to