Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Frank Schweda"'
Autor:
Franziska Werner, Takashi Naruke, Lydia Sülzenbrück, Sarah Schäfer, Melanie Rösch, Katharina Völker, Lisa Krebes, Marco Abeßer, Dorothe Möllmann, Hideo A. Baba, Frank Schweda, Alma Zernecke, Michaela Kuhn
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7800 (2024)
Endothelial dysfunction is cause and consequence of cardiovascular diseases. The endothelial hormone C-type natriuretic peptide (CNP) regulates vascular tone and the vascular barrier. Its cGMP-synthesizing guanylyl cyclase-B (GC-B) receptor is expres
Externí odkaz:
https://doaj.org/article/9f98b9906f7e4e0c96273ae0792c7c1f
Autor:
Frederick Sinha, Anna Federlein, Annika Biesold, Magdalena Schwarzfischer, Katharina Krieger, Frank Schweda, Philipp Tauber
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The inhibition of renal SGLT2 glucose reabsorption has proven its therapeutic efficacy in chronic kidney disease. SGLT2 inhibitors (SGLTi) have been intensively studied in rodent models to identify the mechanisms of SGLT2i-mediated nephroprotection.
Externí odkaz:
https://doaj.org/article/715ee4e21af541b8bc6e91d1b325228e
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14198 (2023)
Chronic kidney disease (CKD) is associated with a significantly increased risk of cardiovascular events and sudden cardiac death. Although arrhythmias are one of the most common causes of sudden cardiac death in CKD patients, the molecular mechanisms
Externí odkaz:
https://doaj.org/article/94c357da691a4120b4cee046fed57a38
Autor:
Philipp Tauber, Frederick Sinha, Raffaela S. Berger, Wolfram Gronwald, Katja Dettmer, Michaela Kuhn, Maximilian Trum, Lars S. Maier, Stefan Wagner, Frank Schweda
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Large-scale clinical outcome studies demonstrated the efficacy of SGLT2 inhibitors in patients with type II diabetes. Besides their therapeutic efficacy in diabetes, significant renoprotection was observed in non-diabetic patients with chronic kidney
Externí odkaz:
https://doaj.org/article/425b5cc5bd5d407aabe01f2b4f8ecc5e
Autor:
Sara Maslanka Figueroa, Daniel Fleischmann, Sebastian Beck, Philipp Tauber, Ralph Witzgall, Frank Schweda, Achim Goepferich
Publikováno v:
Advanced Science, Vol 7, Iss 11, Pp n/a-n/a (2020)
Abstract Poor drug availability in the tissue of interest is a frequent cause of therapy failure. While nanotechnology has developed a plethora of nanocarriers for drug transport, their ability to unequivocally identify cells of interest remains mode
Externí odkaz:
https://doaj.org/article/d6a20a927b644e95865036ed969b73b7
Autor:
Martina Häckl, Philipp Tauber, Frank Schweda, Helena U. Zacharias, Michael Altenbuchinger, Peter J. Oefner, Wolfram Gronwald
Publikováno v:
Metabolites, Vol 11, Iss 7, p 452 (2021)
NMR spectroscopy is a widely used method for the detection and quantification of metabolites in complex biological fluids. However, the large number of metabolites present in a biological sample such as urine or plasma leads to considerable signal ov
Externí odkaz:
https://doaj.org/article/265a600f55a745d29fd16e9a0f3b4717
Autor:
Ramesh Chennupati, Angela Wirth, Julie Favre, Rui Li, Rémy Bonnavion, Young-June Jin, Astrid Wietelmann, Frank Schweda, Nina Wettschureck, Daniel Henrion, Stefan Offermanns
Publikováno v:
eLife, Vol 8 (2019)
Myogenic vasoconstriction is an autoregulatory function of small arteries. Recently, G-protein-coupled receptors have been involved in myogenic vasoconstriction, but the downstream signalling mechanisms and the in-vivo-function of this myogenic autor
Externí odkaz:
https://doaj.org/article/bfbbce460cf24c5d9cfddef654722638
Autor:
Andrea Schramm, Frank Schweda, Maria Luisa S. Sequeira-Lopez, Franz Hofmann, Peter Sandner, Jens Schlossmann
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Pharmacological inhibition of the renin–angiotensin–aldosterone system (RAAS) is, in combination with diuretics, the first-choice treatment for hypertension, although 10–20% of patients do not respond adequately. Next to the RAAS, the nitric ox
Externí odkaz:
https://doaj.org/article/f1dd0992956244cebdad3f17423f8eda
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68009 (2013)
Adenylyl cyclase type 5 (AC5) was described as major cardiac AC isoform. The knockout of AC5 (AC5KO) exerted cardioprotective effects in heart failure. Our study explored the impact of AC5KO on mouse heart AC activities and evaluated putative AC5-sel
Externí odkaz:
https://doaj.org/article/401fe15303a04935a7b0a8fedde5258a
Autor:
Elena-Sofia, Heinl, Katharina Anna-Elisabeth, Broeker, Claudia, Lehrmann, Rosmarie, Heydn, Katharina, Krieger, Katharina, Ortmaier, Philipp, Tauber, Frank, Schweda
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 475:343-360
The natriuretic peptides (NPs) ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide) mediate their widespread effects by activating the natriuretic peptide receptor-A (NPR-A), while C-type natriuretic peptide (CNP) acts via natriureti