Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Frank Schmiedel"'
Autor:
Michelle L. Halls, Julie Sanchez, Claudia Alamein, Meritxell Canals, Alexander Gillis, Frank Schmiedel, J. Robert Lane, Tristan A. Reekie, Preeti Manandhar, Michael Kassiou, Mark Connor, Andrea Kliewer, MacDonald J. Christie, Arisbel B. Gondin, Timothy A. Katte, Marina Santiago, Cornelius Krasel, Herman D. Lim, Stefan Schulz, Natasha L. Grimsey, Barrie Kellam, Sebastian Fritzwanker
Publikováno v:
Science signaling. 13(625)
Biased agonism at G protein–coupled receptors describes the phenomenon whereby some drugs can activate some downstream signaling activities to the relative exclusion of others. Descriptions of biased agonism focusing on the differential engagement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9a0b0ae30a514d390609b92d3b0fab
https://pubmed.ncbi.nlm.nih.gov/32234959
https://pubmed.ncbi.nlm.nih.gov/32234959
Autor:
Stefan Schulz, Graeme Henderson, Rob Hill, Alexander Gillis, Eamonn Kelly, MacDonald J. Christie, Andrea Kliewer, Christopher P Bailey, Frank Schmiedel
Publikováno v:
Br J Pharmacol
British Journal of Pharmacology
Kliewer, A, Gillis, A, Hill, R, Schmidel, F, Bailey, C, Kelly, E, Henderson, G, Christie, M J & Schulz, S 2020, ' Morphine-induced respiratory depression is independent of β-arrestin2 signalling ', British Journal of Pharmacology . https://doi.org/10.1111/bph.15004, https://doi.org/10.1111/bph.15004
British Journal of Pharmacology
Kliewer, A, Gillis, A, Hill, R, Schmidel, F, Bailey, C, Kelly, E, Henderson, G, Christie, M J & Schulz, S 2020, ' Morphine-induced respiratory depression is independent of β-arrestin2 signalling ', British Journal of Pharmacology . https://doi.org/10.1111/bph.15004, https://doi.org/10.1111/bph.15004
BACKGROUND AND PURPOSE: GPCRs can signal through both G proteins and β-arrestin2. For the μ-opioid receptor, early experimental evidence from a single study suggested that G protein signalling mediates analgesia, whereas β-arrestin2 signalling med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d783906f01696cd052f8780289471c26
https://pubmed.ncbi.nlm.nih.gov/32462692
https://pubmed.ncbi.nlm.nih.gov/32462692
Autor:
MacDonald J. Christie, Frank Schmiedel, Jordan T. Bateman, John T. Williams, Erica S. Levitt, Stefan Schulz, Andrea Kliewer, Setareh Sianati, Alexis Bailey
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Opioid analgesics are powerful pain relievers; however, over time, pain control diminishes as analgesic tolerance develops. The molecular mechanisms initiating tolerance have remained unresolved to date. We have previously shown that desensitization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903c7fefdcb5d99ab42f415f59f6647b
https://openaccess.sgul.ac.uk/id/eprint/110559/1/s41467-018-08162-1.pdf
https://openaccess.sgul.ac.uk/id/eprint/110559/1/s41467-018-08162-1.pdf
