Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels

Autor: Frank S Choveau, Ismail Ben Soussia, Delphine Bichet, Chatelain C. Franck, Sylvain Feliciangeli, Florian Lesage

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Inhibitory potassium channels of the TREK1/TRAAK family are integrators of multiple stimuli, including temperature, membrane stretch, polyunsaturated fatty acids and pH. How these signals affect the gating of these channels is the subject of intense

Externí odkaz: https://doaj.org/article/07d33a38848c4d0183ced9c73c1ad2aa

Opposite effects of the S4-S5 linker and PIP2 on voltage-gated channel function: KCNQ1/KCNE1 and other channels

Autor: Frank S Choveau, Fayal eAbderemane-Ali, Fabien C Coyan, Zeineb eEs-Salah-Lamoureux, Isabelle eBaro, Gildas eLoussouarn

Publikováno v: Frontiers in Pharmacology, Vol 3 (2012)

Voltage-gated potassium (Kv) channels are tetramers, each subunit presenting six transmembrane segments (S1-S6), with each S1-S4 segments forming a voltage-sensing domain (VSD) and the four S5-S6 forming both the conduction pathway and its gate. S4 s

Externí odkaz: https://doaj.org/article/905354626e3f4895b355789880175805

Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels

Autor: Ismail Ben Soussia, Chatelain C Franck, Florian Lesage, Frank S. Choveau, Sylvain Feliciangeli, Delphine Bichet

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Frontiers, 2021, 12, ⟨10.3389/fphar.2021.755826⟩
Frontiers in Pharmacology, Frontiers, 2021, 12, pp.755826. ⟨10.3389/fphar.2021.755826⟩
Frontiers in Pharmacology, Vol 12 (2021)

International audience; Inhibitory potassium channels of the TREK1/TRAAK family are integrators of multiple stimuli, including temperature, membrane stretch, polyunsaturated fatty acids and pH. How these signals affect the gating of these channels is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c09d12df5f13270474b1eac153037f
https://hal.archives-ouvertes.fr/hal-03440192

Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons

Autor: Mark S. Shapiro, Jie Zhang, Chase M. Carver, Frank S. Choveau

Publikováno v: Neuron. 92:461-478

The fidelity of neuronal signaling requires organization of signaling molecules into macromolecular complexes, whose components are in intimate proximity. The intrinsic diffraction limit of light makes visualization of individual signaling complexes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955bf1c6ad8e657b1f38327032cffc1c
https://doi.org/10.1016/j.neuron.2016.09.014

Phosphatidylinositol 4,5-bisphosphate (PIP

Autor: Frank S, Choveau, Victor, De la Rosa, Sonya M, Bierbower, Ciria C, Hernandez, Mark S, Shapiro

Publikováno v: The Journal of biological chemistry. 293(50)

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) in the plasma membrane regulates the function of many ion channels, including M-type (potassium voltage-gated channel subfamily Q member (KCNQ), K(v)7) K(+) channels; however, the molecular mechanisms in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7474cb90bcf28ccf56ed248defe60d02
https://pubmed.ncbi.nlm.nih.gov/30348901