Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels

Autor: Frank S Choveau, Ismail Ben Soussia, Delphine Bichet, Chatelain C. Franck, Sylvain Feliciangeli, Florian Lesage

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Inhibitory potassium channels of the TREK1/TRAAK family are integrators of multiple stimuli, including temperature, membrane stretch, polyunsaturated fatty acids and pH. How these signals affect the gating of these channels is the subject of intense

Externí odkaz: https://doaj.org/article/07d33a38848c4d0183ced9c73c1ad2aa

Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels

Autor: Ismail Ben Soussia, Frank S. Choveau, Sandy Blin, Eun-Jin Kim, Sylvain Feliciangeli, Franck C. Chatelain, Dawon Kang, Delphine Bichet, Florian Lesage

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

TREK/TRAAK channels are polymodal K+ channels that convert very diverse stimuli, including bioactive lipids, mechanical stretch and temperature, into electrical signals. The nature of the structural changes that regulate their activity remains an ope

Externí odkaz: https://doaj.org/article/67683d0d8ef84390be2c9f1f6e496be8

Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels

Autor: Ismail Ben Soussia, Chatelain C Franck, Florian Lesage, Frank S. Choveau, Sylvain Feliciangeli, Delphine Bichet

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Frontiers, 2021, 12, ⟨10.3389/fphar.2021.755826⟩
Frontiers in Pharmacology, Frontiers, 2021, 12, pp.755826. ⟨10.3389/fphar.2021.755826⟩
Frontiers in Pharmacology, Vol 12 (2021)

International audience; Inhibitory potassium channels of the TREK1/TRAAK family are integrators of multiple stimuli, including temperature, membrane stretch, polyunsaturated fatty acids and pH. How these signals affect the gating of these channels is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c09d12df5f13270474b1eac153037f
https://hal.archives-ouvertes.fr/hal-03440192

Phosphatidylinositol 4,5-bisphosphate (PIP2) regulates KCNQ3 K+ channels by interacting with four cytoplasmic channel domains

Autor: Sonya M. Bierbower, Frank S. Choveau, Ciria C. Hernandez, Mark S. Shapiro, Victor De la Rosa

Publikováno v: Journal of Biological Chemistry. 293:19411-19428

Phosphatidylinositol 4,5-bisphosphate (PIP2) in the plasma membrane regulates the function of many ion channels, including M-type (potassium voltage-gated channel subfamily Q member (KCNQ), Kv7) K+ channels; however, the molecular mechanisms involved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::657f6eae029bc50495ceed235dc3503a
https://doi.org/10.1074/jbc.ra118.005401

Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons

Autor: Mark S. Shapiro, Jie Zhang, Chase M. Carver, Frank S. Choveau

Publikováno v: Neuron. 92:461-478

The fidelity of neuronal signaling requires organization of signaling molecules into macromolecular complexes, whose components are in intimate proximity. The intrinsic diffraction limit of light makes visualization of individual signaling complexes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955bf1c6ad8e657b1f38327032cffc1c
https://doi.org/10.1016/j.neuron.2016.09.014