Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Frank Rusnak"'
Publikováno v:
Journal of Bacteriology. 186:5427-5431
Isoniazid (INH), a front-line antituberculosis agent, is activated by mycobacterial catalase-peroxidase KatG, converting INH into bactericidal reactive species. Here we investigated the requirements and the pathway of nitric oxide (NO˙) generation d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955f840334182ff43a249a4eb19b53fd
https://doi.org/10.1128/jb.186.16.5427-5431.2004
https://doi.org/10.1128/jb.186.16.5427-5431.2004
Autor:
Frank Rusnak, Tiffany A. Reiter
Publikováno v:
Biochemistry. 43:782-790
Bacteriophage lambda protein phosphatase (lambdaPP) is a member of a large superfamily of metallophosphoesterases, including serine/threonine protein phosphatases, purple acid phosphatases, 5'-nucleotidase, and DNA repair enzymes such as Mre11. Membe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7feeb5b877ed171ce7fa6c8db08f2d53
https://doi.org/10.1021/bi0356956
https://doi.org/10.1021/bi0356956
Autor:
David G. Kehres, Scott W. Bearden, Carson J. La Vake, Frank Rusnak, Justin D. Radolf, Michael E. Maguire, Morgan E. La Vake, Robert D. Perry, Karsten R. O. Hazlett
Publikováno v:
Journal of Biological Chemistry. 278:20687-20694
The Treponema pallidum tro operon encodes an ABC transporter (TroABCD), a transcriptional repressor (TroR), and the essential glycolytic enzyme phosphoglycerate mutase (Gpm). The apparently discordant observations that the solute binding protein (Tro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435ae0e154df940ba122d42eaf19c20b
https://doi.org/10.1074/jbc.m300781200
https://doi.org/10.1074/jbc.m300781200
Publikováno v:
Journal of Inorganic Biochemistry. 93:100-108
The differences in geometry at the metal centres in the two known [Fe–4S] proteins rubredoxin (Rd) and desulforedoxin (Dx) are postulated to be a result of the different spacing of the C-terminal cysteine pair in the two proteins. In order to addre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fabe126eb4e02515a5cb6c0f1f03606
https://doi.org/10.1016/s0162-0134(02)00458-0
https://doi.org/10.1016/s0162-0134(02)00458-0
Publikováno v:
Biochemistry. 41:15404-15409
Bacteriophage lambda protein phosphatase (lambdaPP) is a member of a large family of metal-containing phosphoesterases, including purple acid phosphatase, protein serine/threonine phosphatases, 5'-nucleotidase, and DNA repair enzymes such as Mre11. l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c78d0003214f267d13fc4fe79573e4b
https://doi.org/10.1021/bi026317o
https://doi.org/10.1021/bi026317o
Autor:
Frank Rusnak, Françoise Auchère
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 7:664-667
For three decades, oxidative stress and the role of reactive oxygen species in biology have been extensively studied. Recently, a new interest in these areas has emerged with the discovery of superoxide reductases, a family of familiar bacterial meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164a5b6780984deda8e15ced86f732a8
https://doi.org/10.1007/s00775-002-0362-2
https://doi.org/10.1007/s00775-002-0362-2
Publikováno v:
Biochemistry. 41:1051-1059
Bacteriophage lambda protein phosphatase (lambdaPP) with Mn(2+) as the activating metal cofactor was studied using phosphatase inhibition kinetics and electron paramagnetic resonance (EPR) spectroscopy. Orthophosphate and the oxoanion analogues ortho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074f53a3e30f140112644fcc0242a91f
https://doi.org/10.1021/bi011577b
https://doi.org/10.1021/bi011577b
Publikováno v:
Biochemistry. 40:8918-8929
Bacteriophage lambda phosphoprotein phosphatase (lambdaPP) has structural similarity to the mammalian Ser/Thr phosphoprotein phosphatases (PPPs) including the immunosuppressant drug target calcineurin. PPPs possess a conserved active site containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f6c46dd653e1577bb4a51aa208c88c
https://doi.org/10.1021/bi010637a
https://doi.org/10.1021/bi010637a
Autor:
Frank Rusnak, Nancy L. Wengenack
Publikováno v:
Biochemistry. 40:8990-8996
The antitubercular agent isoniazid can be activated by Mycobacterium tuberculosis KatG using either a peroxidase compound I/II or a superoxide-dependent oxyferrous pathway. The identity of activated isoniazid is unknown, but it has been suggested tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69eaee6962bb175037e123bce99fb034
https://doi.org/10.1021/bi002614m
https://doi.org/10.1021/bi002614m
Publikováno v:
Journal of Biological Chemistry. 276:835-843
Pneumocystis carinii is an opportunistic fungal pathogen phylogenetically related to the fission yeast Schizosaccharomyces pombe. P. carinii causes severe pneumonia in immunocompromised patients with AIDS and malignancies. Although the life cycle of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578369e1cac6459fbe36329f8ca1c1ed
https://doi.org/10.1074/jbc.m007814200
https://doi.org/10.1074/jbc.m007814200