Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Frank Runge"'
Autor:
Anna-Kaisa Rimpelä, Michel Garneau, Katja S. Baum-Kroker, Tanja Schönberger, Frank Runge, Achim Sauer
Publikováno v:
Pharmaceutics, Vol 12, Iss 12, p 1174 (2020)
The rat is a commonly used species in ocular drug research. Detailed methods of separating rat ocular tissues have not been described in literature. To understand the intraocular drug distribution, we developed a robust method for the separation of i
Externí odkaz:
https://doaj.org/article/40c26c3a9cb9433e9e1f974a09ebe070
Publikováno v:
Pharmaceutics, Vol 12, Iss 5, p 405 (2020)
The Caco-2 model is a well-accepted in vitro model for the estimation of fraction absorbed in human intestine. Due to the lack of cytochrome P450 3A4 (CYP3A4) activities, Caco-2 model is not suitable for the investigation of intestinal first-pass met
Externí odkaz:
https://doaj.org/article/b823dcf6935c41d2a76c09651b0d8d61
Autor:
Lyubov Chaykovska, Karoline von Websky, Jan Rahnenführer, Markus Alter, Susi Heiden, Holger Fuchs, Frank Runge, Thomas Klein, Berthold Hocher
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27861 (2011)
BACKGROUND: Uremic cardiomyopathy contributes substantially to mortality in chronic kidney disease (CKD) patients. Glucagon-like peptide-1 (GLP-1) may improve cardiac function, but is mainly degraded by dipeptidyl peptidase-4 (DPP-4). METHODOLOGY/PRI
Externí odkaz:
https://doaj.org/article/4e4526f9dc6a4249a3ac5af61f79976c
Autor:
Simone Schadt, Andreas Sutter, Dieter Lang, Frank Runge, Andreas Zeller, Alessandro Brigo, Andreas Brink, Esther Vock, Jörg Wichard, Wolfgang Muster, Melanie Guérard
Publikováno v:
Chemical Research in Toxicology. 33:10-19
While there are dedicated guidelines for industry regarding the assessment of the genotoxic potential of new pharmaceuticals and impurities, and the general safety assessment of major drug metabolites, only limited guidance exists on the assessment o
Autor:
Daniel Bischoff, Robert Ries, Yuting Wang, Wolfgang Reindl, Tim T. Häbe, Martin Winter, Frank H. Büttner, Frank Runge, Roman P. Simon, Andreas H. Luippold, Amaury Fernández-Montalván
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(8)
Acoustic droplet ejection (ADE)-open port interface (OPI)-mass spectrometry (MS) has recently been introduced as a versatile analytical method that combines fast and contactless acoustic sampling with sensitive and accurate electrospray ionization (E
Autor:
Frank Runge, Anna-Kaisa Rimpelä, Achim Sauer, Michel Garneau, Katja S. Baum-Kroker, Tanja Schönberger
Publikováno v:
Pharmaceutics, Vol 12, Iss 1174, p 1174 (2020)
Pharmaceutics
Volume 12
Issue 12
Pharmaceutics
Volume 12
Issue 12
The rat is a commonly used species in ocular drug research. Detailed methods of separating rat ocular tissues have not been described in literature. To understand the intraocular drug distribution, we developed a robust method for the separation of i
Autor:
Frank Runge
Eigentlich wollte Finn lediglich sein Leben auf die Reihe bekommen. Doch die göttliche Vorsehung hatte andere Pläne mit ihm. Was für die Gelehrten untergegangener Hochkulturen grundlegendes Wissen war und für die Wissenschaft, bis zum erforschen
Autor:
Gisela Schnapp, Wolfgang Reindl, Carola Kleiner, Andreas H. Luippold, Robert Ries, Daniel Bischoff, Dennis Fiegen, Markus Zeeb, Martin Winter, Roman P. Simon, Michael Karnath, Tim T. Häbe, Frank Runge, Tom Bretschneider, Lucie Wehrle, Frank H. Büttner
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(1)
Demonstration of in vitro target engagement for small-molecule ligands by measuring binding to a molecular target is an established approach in early drug discovery and a pivotal step in high-throughput screening (HTS)-based compound triaging. We des
Autor:
Chang Liu, Daniel Bischoff, Wolfgang Reindl, Frank Runge, Andreas H. Luippold, Roman P. Simon, Martin Winter, Frank H. Büttner, Tim T. Häbe, Thomas R. Covey
Publikováno v:
Analytical chemistry. 92(18)
We present an acoustic ejection mass spectrometry (AEMS) setup for contactless electrospray ionization mass spectrometry (ESI-MS)-based sample injection at a sampling rate faster than current ESI and matrix-assisted laser desorption ionization (MALDI
Autor:
Cornelis E. C. A. Hop, Swapan Chowdhury, Douglas K. Spracklin, Simone Schadt, Christoph Funk, W. Griffith Humphreys, Angus N. R. Nedderman, Fumihiko Igarashi, Josh Yuan, Chandra Prakash, Frank Runge, Holger Scheible, Mark Kagan, S. Cyrus Khojasteh, Piet Swart, R. Scott Obach, Bojan Bister, Alexander David James, Susanna Tse
Publikováno v:
BASE-Bielefeld Academic Search Engine
Since the introduction of metabolites in safety testing (MIST) guidance by the Food and Drug Administration in 2008, major changes have occurred in the experimental methods for the identification and quantification of metabolites, ways to evaluate co