Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Frank Rosenbauer"'
Autor:
Inna Shaforostova, Simon Call, Georg Evers, Christian Reicherts, Linus Angenendt, Matthias Stelljes, Wolfgang E. Berdel, Alexander Pohlmann, Jan‐Henrik Mikesch, Frank Rosenbauer, Georg Lenz, Christoph Schliemann, Klaus Wethmar
Publikováno v:
eJHaem, Vol 5, Iss 1, Pp 93-104 (2024)
Abstract Flow cytometry‐based immunophenotyping is a mainstay of diagnostics in acute myeloid leukaemia (AML). Aberrant CD56 and T‐cell antigen expression is observed in a fraction subset of AML cases, but the clinical relevance remains incomplet
Externí odkaz:
https://doaj.org/article/88331a79d0454531ba11c14b63ff48ce
Autor:
Xiaoqing Xie, Pradeep Kumar Patnana, Daria Frank, Judith Schütte, Yahya Al-Matary, Axel Künstner, Hauke Busch, Helal Ahmed, Longlong Liu, Daniel R. Engel, Ulrich Dührsen, Frank Rosenbauer, Nikolas Von Bubnoff, Georg Lenz, Cyrus Khandanpour
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
GFI1 is a transcriptional repressor and plays a pivotal role in regulating the differentiation of hematopoietic stem cells (HSCs) towards myeloid and lymphoid cells. Serial transplantation of Gfi1 deficient HSCs repopulated whole hematopoietic system
Externí odkaz:
https://doaj.org/article/bba119766778494f9bbb40bed1966dda
Autor:
Vijayashree Mysore, Xavier Cullere, Joseph Mears, Florencia Rosetti, Koshu Okubo, Pei X. Liew, Fan Zhang, Iris Madera-Salcedo, Frank Rosenbauer, Richard M. Stone, Jon C. Aster, Ulrich H. von Andrian, Andrew H. Lichtman, Soumya Raychaudhuri, Tanya N. Mayadas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
Neutrophils are versatile immune cells that may also serve as antigen-presenting cells (APC). Here the authors show that engaging FcγRs on neutrophils with immune complexes or an anti-FcγR-antigen conjugate induces neutrophil APC with comparable fu
Externí odkaz:
https://doaj.org/article/86a5a1c6c18f436081a1927c18c8de2d
Autor:
Melinda Czeh, Frank Rosenbauer
Publikováno v:
Molecular & Cellular Oncology, Vol 4, Iss 2 (2017)
Although acute myeloid leukaemia (AML) is assumed to be driven by transformed haematopoietic stem and progenitor cells, we have described recently a new pathway leading to AML from T-cell progenitors. Furthermore, we could identify a subgroup of huma
Externí odkaz:
https://doaj.org/article/1b262700f3fd43d5aa6c4736734b1705
PU.1 Level-Directed Chromatin Structure Remodeling at the Irf8 Gene Drives Dendritic Cell Commitment
Autor:
Jörg Schönheit, Christiane Kuhl, Marie Luise Gebhardt, Francisco Fernández Klett, Pia Riemke, Marina Scheller, Gang Huang, Ronald Naumann, Achim Leutz, Carol Stocking, Josef Priller, Miguel A. Andrade-Navarro, Frank Rosenbauer
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1617-1628 (2013)
Dendritic cells (DCs) are essential regulators of immune responses; however, transcriptional mechanisms that establish DC lineage commitment are poorly defined. Here, we report that the PU.1 transcription factor induces specific remodeling of the hig
Externí odkaz:
https://doaj.org/article/86800f3f9abb4916b860a7e7cbfd334e
Autor:
Katharina, Gerlach, Vanessa, Popp, Stefan, Wirtz, Ragheed, Al-Saifi, Miguel, Gonzalez Acera, Raja, Atreya, Theresa, Dregelies, Michael, Vieth, Stefan, Fichtner-Feigl, Andrew N J, McKenzie, Frank, Rosenbauer, Benno, Weigmann, Markus F, Neurath
Publikováno v:
Journal of Crohn's and Colitis. 16:1893-1910
Background and Aims Colorectal cancer [CRC] is one of the most frequent malignancies, but the molecular mechanisms driving cancer growth are incompletely understood. We characterised the roles of the cytokine IL-9 and Th9 cells in regulating CRC deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5979a4bde026ffba4a6904d9c5a488dc
https://doi.org/10.1093/ecco-jcc/jjac097
https://doi.org/10.1093/ecco-jcc/jjac097
Autor:
Melinda Czeh, Sina Stäble, Stephen Krämer, Lena Tepe, Sweta Talyan, Joana Carrelha, Yiran Meng, Barbara Heitplatz, Marius Schwabenland, Michael D. Milsom, Christoph Plass, Marco Prinz, Matthias Schlesner, Miguel A. Andrade-Navarro, Claus Nerlov, Sten Eirik W. Jacobsen, Daniel B. Lipka, Frank Rosenbauer
Publikováno v:
J Immunol
Dendritic cells (DCs) are heterogeneous immune regulators involved in autoimmune diseases. Epigenomic mechanisms orchestrating DC development and DC subset diversification remain insufficiently understood but could be important to modulate DC fate fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b41ef65019de92ab9fa85f19695709
https://doi.org/10.4049/jimmunol.2100624
https://doi.org/10.4049/jimmunol.2100624
Autor:
Sebastian Gregoricchio, Lélia Polit, Michela Esposito, Jérémy Berthelet, Laure Delestré, Emilie Evanno, M’Boyba Diop, Isabelle Gallais, Hanna Aleth, Mathilde Poplineau, Wilbert Zwart, Frank Rosenbauer, Fernando Rodrigues-Lima, Estelle Duprez, Valentina Boeva, Christel Guillouf
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2022, 50 (14), pp.7938-7958. ⟨10.1093/nar/gkac613⟩
Nucleic Acids Research, 50 (14)
Nucleic Acids Research, 2022, 50 (14), pp.7938-7958. ⟨10.1093/nar/gkac613⟩
Nucleic Acids Research, 50 (14)
Although originally described as transcriptional activator, SPI1/PU.1, a major player in haematopoiesis whose alterations are associated with haematological malignancies, has the ability to repress transcription. Here, we investigated the mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335b9fecb6b839d630b2b0e07f53027e
https://hal.science/hal-03834914/document
https://hal.science/hal-03834914/document
Autor:
Longlong Liu, Pradeep Kumar Patnana, Xiaoqing Xie, Daria Frank, Subbaiah Chary Nimmagadda, Minhua Su, Donghua Zhang, Thorsten Koenig, Frank Rosenbauer, Marie Liebmann, Luisa Klotz, Wendan Xu, Jan Vorwerk, Felix Neumann, Jana Hüve, Andreas Unger, Jürgen Günther Okun, Bertram Opalka, Cyrus Khandanpour
Recent studies highlighted the role of transcription factors in metabolic regulation during hematopoiesis and leukemia development. GFI1B is a transcriptional repressor that plays a critical role in hematopoiesis, and its expression is negatively rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd3639e3e6f9e8ee348926da8507eda
https://www.ncbi.nlm.nih.gov/pubmed/35804097
https://www.ncbi.nlm.nih.gov/pubmed/35804097
Autor:
Jan-Henrik Mikesch, Christoph Schliemann, Yahya Saleh Al-Matary, Wolfgang Hartmann, Jan Tuckermann, Subbaiah Chary Nimmagadda, Tobias May, Martin Dugas, Ulrich Dührsen, Thorsten Koenig, Georg Lenz, Cyrus Khandanpour, Christian Recher, Helal Mohammed Mohammed Ahmed Ahmed, Bertram Opalka, Maren Fiori, Daria Frank, Pradeep Kumar Patnana, Frank Rosenbauer, Wei Lanying
Publikováno v:
British journal of haematologyReferences. 196(4)
Acute myeloid leukaemia (AML) is a haematological malignancy characterized by a poor prognosis. Bone marrow mesenchymal stromal cells (BM MSCs) support leukaemic cells in preventing chemotherapy-induced apoptosis. This encouraged us to investigate le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac41137e46e46309bc3f9c427a46289e
https://pubmed.ncbi.nlm.nih.gov/34792186
https://pubmed.ncbi.nlm.nih.gov/34792186