Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Frank Roschangar"'
Publikováno v:
Organic Process Research & Development. 27:822-830
Autor:
Frank Roschangar, Jun Li, Yanyan Zhou, Wim Aelterman, Alina Borovika, Juan Colberg, David P. Dickson, Fabrice Gallou, John D. Hayler, Stefan G. Koenig, Michael E. Kopach, Birgit Kosjek, David K. Leahy, Erin O’Brien, Austin G. Smith, Manuel Henry, Jutta Cook, Roger A. Sheldon
Publikováno v:
ACS Sustainable Chemistry and Engineering, 10(16)
The large and steadily growing demand for medicines combined with their inherent resource-intensive manufacturing necessitates a relentless push for their sustainable production. Pharmaceutical companies are constantly seeking to perform reliable lif
Autor:
Fabrice Gallou, Frank Roschangar
Publikováno v:
Current Opinion in Green and Sustainable Chemistry. 39:100730
Autor:
Martin Olbrich, Andrew S. Wells, Isamir Martinez, Edward C. Sherer, Martin D. Eastgate, Stefan G. Koenig, Frank Roschangar, Fabrice Gallou, Jun Li, David K. Leahy, Michael E. Kopach, Christiana Briddell, Barry Richard Dillon, Jacob Albrecht, Jared L. Piper, Louis J. Diorazio, Alina Borovika, James R. Gage
Publikováno v:
Nature Sustainability. 2:1034-1040
The development of sustainable processes for the synthesis of new clinical candidates is a priority for every pharmaceutical company. The ultimate efficiency of a molecule’s synthesis results from a combination of the sequence of steps to assemble
Autor:
Helen F. Sneddon, Frank Roschangar, Sudhir Nambiar, Seth D. Ribe, Jeremy P. Scott, Michael E. Kopach, Scott V. Plummer, Guy R. Humphrey, Juan Colberg, Alina Borovika, Christiana Briddell, Isamir Martinez, Cisco Bee, Stefan G. Koenig
Publikováno v:
ACS Sustainable Chemistry & Engineering. 7:16937-16951
In an effort to improve sustainability and reduce the cost of goods for active pharmaceutical ingredients (APIs), pharma companies have partnered on varying portions of their supply chain with cont...
Autor:
Yibo Xu, Jeff J. Song, Yuwen Wang, Li Zhang, Frank Roschangar, Zhengxu S. Han, Linglin Wu, Hao Wu, Heewon Lee, Yongda Zhang, Chris H. Senanayake, Bo Qu, Ling Wu
Publikováno v:
Tetrahedron Letters. 60:1834-1837
A new class of N H Bronsted acid organocatalysts that feature P-stereogenic chirality was developed. These catalysts were prepared from P-stereogenic chiral phosphinamides and show similar reactivity to BINOL derived phosphoric acid toward the reduct
Autor:
Denis Byrne, Zhengxu S. Han, Philomen DeCroos, Bo Qu, Frank Roschangar, Larry Nummy, Yibo Xu, Jinhua J. Song, Jon C. Lorenz, Ling Wu, Chris H. Senanayake, Kanwar Sidhu, Heewon Lee
Publikováno v:
Organic Process Research & Development. 23:263-268
Process development for a scalable and green synthesis of chiral tert-butanesulfinamide (TBSA) on a multikilogram scale is reported. The process is based on the identification of a chiral sulfinyl transfer agent, benzo[1,3]oxathiozin-2-one, that cont
Autor:
Yanchao Xin, Frank Roschangar, Zeena Williams, Denis Byrne, Dmitry Kurouski, Jason A. Mulder, Jinhua J. Song, Alice T. Granger, Laurence J. Nummy, Jon C. Lorenz, Scott Pennino, Frederic G. Buono, Chris H. Senanayake, Yaping Hong, Ajith Premasiri, Nathan K. Yee, Joe Gao, Sonia Rodriguez, Xinzhu Zhang, Bo Qu, Jack D. Brown, Rogelio P. Frutos, Bikshandarkoil A. Narayanan, Zhantong Mao, Azad Hossain, Ning Li, Mariusz Krawiec, Heewon Lee, Yongda Zhang, Zhengxu S. Han, Nizar Haddad, Zhibin Li, Yibo Xu, Nelu Grinberg, Joshua D. Sieber, Carl A. Busacca
Publikováno v:
The Journal of Organic Chemistry. 83:1448-1461
A chromatography-free, asymmetric synthesis of the C2-symmetric P-chiral diphosphine t-Bu-SMS-Phos was developed using a chiral auxiliary-based approach in five steps from the chiral auxiliary in 36% overall yield. Separtion and recovery of the auxil
Autor:
David Entwistle, Michael E. Kopach, Matthew R. Hickey, John D. Hayler, Frank Roschangar, Peter J. Dunn, Fabrice Gallou, Shaun Hughes, Franz J. Weiberth, Stefan G. Koenig, Alan Steven, Gerard Moine, Marian C. Bryan, Paul G. Richardson
Publikováno v:
Green Chemistry. 20:5082-5103
In 2007 the members of the ACS Green Chemistry Institute® Pharmaceutical Roundtable assembled a list of key green chemistry research areas to both identify transformations that would benefit from improvements in process greenness and to encourage ac
Autor:
Zhengxu S. Han, Heewon Lee, Yongda Zhang, Chris H. Senanayake, Hao Wu, Frank Roschangar, Nelu Grinberg, Bo Qu, Dan Wang, Guijun Wang, Jinhua J. Song, Yibo Xu
Publikováno v:
Advanced Synthesis & Catalysis. 359:3927-3933
P-Stereogenic chiral phosphine BI-BOP is employed for the first time as ligand to promote catalytic enantioselective synthesis of phosphoryl-substituted atropisomeric vinylarenes through a palladium−carbene pathway. This strategy utilizes 10 mol% p