Zobrazeno 1 - 10
of 646
pro vyhledávání: '"Frank Porreca"'
Autor:
Shagun Singh, Caroline M. Kopruszinski, Moe Watanabe, David W. Dodick, Edita Navratilova, Frank Porreca
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Sexual dimorphism has been revealed for many neurological disorders including chronic pain. Prelicinal studies and post-mortem analyses from male and female human donors reveal sexual dimorphism of nociceptors at transcript, protein and func
Externí odkaz:
https://doaj.org/article/a3a604c1b7704044a984efcdec7d56f0
Autor:
Stephanie Maciuba, Gregory D. Bowden, Harrison J. Stratton, Kazimierz Wisniewski, Claudio D. Schteingart, Juan C. Almagro, Philippe Valadon, Joshua Lowitz, Scott M. Glaser, Grace Lee, Mahdi Dolatyari, Edita Navratilova, Frank Porreca, Pierre J.M. Rivière
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTProlactin (PRL) has recently been demonstrated to elicit female-selective nociceptor sensitization and increase pain-like behaviors in female animals. Here we report the discovery and characterization of first-in-class, humanized PRL neutrali
Externí odkaz:
https://doaj.org/article/13a501dc4b6048c599396d77471221c9
Autor:
Guangchen Ji, Peyton Presto, Takaki Kiritoshi, Yong Chen, Edita Navratilova, Frank Porreca, Volker Neugebauer
Publikováno v:
Cells, Vol 13, Iss 8, p 705 (2024)
Neuroplasticity in the central nucleus of the amygdala (CeA) plays a key role in the modulation of pain and its aversive component. The dynorphin/kappa opioid receptor (KOR) system in the amygdala is critical for averse-affective behaviors in pain co
Externí odkaz:
https://doaj.org/article/3f8baf48ad0344dcbdf6bf15b5b55cec
Autor:
Caroline M. Kopruszinski, Robson Vizin, Moe Watanabe, Ashley L. Martinez, Luiz Henrique Moreira de Souza, David W. Dodick, Frank Porreca, Edita Navratilova
Publikováno v:
The Journal of Headache and Pain, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background The migraine premonitory phase is characterized in part by increased thirst, urination and yawning. Imaging studies show that the hypothalamus is activated in the premonitory phase. Stress is a well know migraine initiation factor
Externí odkaz:
https://doaj.org/article/273e123ac578484ab8e09f338c377a8f
Autor:
Daisuke Sato, Michiko Narita, Yusuke Hamada, Tomohisa Mori, Kenichi Tanaka, Hideki Tamura, Akihiro Yamanaka, Ryosuke Matsui, Dai Watanabe, Yukari Suda, Emiko Senba, Moe Watanabe, Edita Navratilova, Frank Porreca, Naoko Kuzumaki, Minoru Narita
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-13 (2022)
Abstract Emerging evidence suggests that the mesolimbic dopaminergic network plays a role in the modulation of pain. As chronic pain conditions are associated with hypodopaminergic tone in the nucleus accumbens (NAc), we evaluated the effects of incr
Externí odkaz:
https://doaj.org/article/19e7e40f2ad442088b88dd6d70e75c50
Publikováno v:
Frontiers in Pain Research, Vol 3 (2023)
Externí odkaz:
https://doaj.org/article/c378fec6832f485396b783eaf40cb62b
Autor:
Vadim Yakhnitsa, Guangchen Ji, Matthew Hein, Peyton Presto, Zack Griffin, Olga Ponomareva, Edita Navratilova, Frank Porreca, Volker Neugebauer
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Functional pain syndromes (FPS) occur in the absence of identifiable tissue injury or noxious events and include conditions such as migraine, fibromyalgia, and others. Stressors are very common triggers of pain attacks in various FPS conditions. It h
Externí odkaz:
https://doaj.org/article/42cbe05d1d884554ad81d69fa1813fe3
Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism
Autor:
Yeon Sun Lee, Michael Remesic, Cyf Ramos-Colon, Zhijun Wu, Justin LaVigne, Gabriella Molnar, Dagmara Tymecka, Aleksandra Misicka, John M. Streicher, Victor J. Hruby, Frank Porreca
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 625 (2021)
In our previous studies, we developed a series of mixed MOR/DOR agonists that are enkephalin-like tetrapeptide analogs with an N-phenyl-N-piperidin-4-ylpropionamide (Ppp) moiety at the C-terminus. Further SAR study on the analogs, initiated by the fi
Externí odkaz:
https://doaj.org/article/5b6b2c3eba6f414bbf633d9023f2ac2b
Autor:
Hassan Jassar, Thiago D. Nascimento, Niko Kaciroti, Marcos F. DosSantos, Theodora Danciu, Robert A. Koeppe, Yolanda R. Smith, Marcelo E. Bigal, Frank Porreca, Kenneth L. Casey, Jon-Kar Zubieta, Alexandre F. DaSilva
Publikováno v:
NeuroImage: Clinical, Vol 23, Iss , Pp - (2019)
Objective: To evaluate, in vivo, the impact of ongoing chronic migraine (CM) attacks on the endogenous μ-opioid neurotransmission. Background: CM is associated with cognitive-emotional dysfunction. CM is commonly associated with frequent acute medic
Externí odkaz:
https://doaj.org/article/f2cb501c063c4c8b9171a7916c60f3a0
Autor:
Aubin Moutal, Nathan Eyde, Edwin Telemi, Ki Duk Park, Jennifer Y. Xie, David W. Dodick, Frank Porreca, Rajesh Khanna
Publikováno v:
PAIN Reports, Vol 1, Iss 1, p e565 (2016)
Abstract. Migraine is one of the world's most common neurological disorders. Current acute migraine treatments have suboptimal efficacy, and new therapeutic options are needed. Approaches targeting calcitonin gene related peptide (CGRP) signaling are
Externí odkaz:
https://doaj.org/article/b76fbad023a2448786fef6d6f182ed96