Výsledky vyhledávání - "Frank P.T. Hamers"

Functional Recovery, Serotonergic Sprouting, and Endogenous Progenitor Fates in Response to Delayed Environmental Enrichment after Spinal Cord Injury

Autor: Frank P.T. Hamers, Ronald Deumens, Wiel Honig, Guido C Koopmans, Elbert A.J. Joosten, Maarten van Kleef, Jörg Mey

Publikováno v: Journal of Neurotrauma, 29(3), 514-527. Mary Ann Liebert Inc.

Environmental enrichment (EE) is a way to induce voluntary locomotor training that positively affects locomotor recovery after acute spinal cord injury (SCI). The beneficial effect on SCI outcome is thought to be based on enhanced plasticity in motor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f54e085aa5b6b38edc391a647a9c695
https://doi.org/10.1089/neu.2011.1949

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Deficiency in Complement C1q Improves Histological and Functional Locomotor Outcome after Spinal Cord Injury

Autor: Adrian M. Burgos, Manuel D. Galvan, Frank P.T. Hamers, Hal X. Nguyen, Mitra J. Hooshmand, Sabina Luchetti, Aileen J. Anderson

Publikováno v: The Journal of Neuroscience. 28:13876-13888

Although studies have suggested a role for the complement system in the pathophysiology of spinal cord injury (SCI), that role remains poorly defined. Additionally, the relative contribution of individual complement pathways in SCI is unknown. Our in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46a357673bda5901e7410caa658147d
https://doi.org/10.1523/jneurosci.2823-08.2008

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Intraspinal administration of an antibody against CD81 enhances functional recovery and tissue sparing after experimental spinal cord injury

Autor: Peter R. Bär, W.H. Gispen, Eldon E. Geisert, S. Dijkstra, Alex J. Lankhorst, Frank P.T. Hamers, Elbert A.J. Joosten, Simone E.J. Duis, I.M. Pans, H. Veldman

Publikováno v: Experimental Neurology. 202:57-66

We previously demonstrated that the tetraspanin protein CD81 is up-regulated by astrocytes and microglia after traumatic spinal cord injury in rats and that CD81 is involved in adhesion and proliferation of cultured astrocytes and microglia. Since th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bb402530702da21459181a67cd4b8d
https://doi.org/10.1016/j.expneurol.2006.05.011

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Olfactory ensheathing cells, olfactory nerve fibroblasts and biomatrices to promote long-distance axon regrowth and functional recovery in the dorsally hemisected adult rat spinal cord

Autor: Véronique Maquet, Robert Jérôme, W. M. M. Honig, Frank P.T. Hamers, Ronald Deumens, E. A. J. Joosten, Harry W.M. Steinbusch, Guido C Koopmans

Publikováno v: Experimental Neurology. 200:89-103

Cellular transplantation, including olfactory ensheathing cells (OEC) and olfactory nerve fibroblasts (ONF), after experimental spinal cord injury in the rat has previously resulted in regrowth of severed corticospinal (CS) axons across small lesion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80f38ed2609128cce8780ba9df8e6ee
https://doi.org/10.1016/j.expneurol.2006.01.030

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The Assessment of Locomotor Function in Spinal Cord Injured Rats: The Importance of Objective Analysis of Coordination

Autor: Frank P.T. Hamers, Harry W.M. Steinbusch, Ronald Deumens, Wiel Honig, Elbert A.J. Joosten, Guido C Koopmans

Publikováno v: Journal of Neurotrauma. 22:214-225

The Basso, Beattie and Bresnahan (BBB) locomotor rating scale is the most widely used open field test and has been accepted as a valid way to assess locomotor function after spinal cord contusion injury in the rat. A limitation within the BBB locomot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92f59d44b596a4813dd683efe1fc17f
https://doi.org/10.1089/neu.2005.22.214

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Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain genePitx3

Autor: Simone M. Smits, Frank P.T. Hamers, Marten P. Smidt, Annemarie J. A. van der Linden, Anita J. C. G. M. Hellemons, Jochen Graw, J. Peter H. Burbach, Hans Bouwmeester

Publikováno v: Development 131 (2004) 5
Development, 131(5), 1145-1155
Development 131, 1145-1155 (2004)

The mesencephalic dopamine (mesDA) system is involved in the control of movement and behavior. The expression of Pitx3 in the brain is restricted to the mesDA system and the gene is induced relatively late, at E11.5, a time when tyrosine hydroxylase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a967fd70f265538eb194ebc12cd0aa
https://doi.org/10.1242/dev.01022

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Ex Vivo Adenoviral Vector-Mediated Neurotrophin Gene Transfer to Olfactory Ensheathing Glia: Effects on Rubrospinal Tract Regeneration, Lesion Size, and Functional Recovery after Implantation in the Injured Rat Spinal Cord

Autor: Gerard J. Boer, Willem Hendrik Gispen, Joost Verhaagen, Bas Blits, Paul A. Dijkhuizen, Frank P.T. Hamers, Marc J. Ruitenberg, Giles W. Plant, Joke Wortel

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(18), 7045-58. Society for Neuroscience

The present study uniquely combines olfactory ensheathing glia (OEG) implantation with ex vivo adenoviral (AdV) vector-based neurotrophin gene therapy in an attempt to enhance regeneration after cervical spinal cord injury. Primary OEG were transduce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f1765782e28d8f732884632fb79cec
https://doi.org/10.1523/jneurosci.23-18-07045.2003

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Systemic co-treatment with α-melanocyte stimulating hormone delays hearing loss caused by local cisplatin administration in guinea pigs

Autor: Frank P.T. Hamers, Francisca L.C. Wolters, Diane M. Prieskorn, Guido F. Smoorenburg, Sjaak F.L. Klis, John C.M.J. de Groot, Josef M. Miller

Publikováno v: Hearing Research. 179:53-61

It has previously been demonstrated that ototoxicity induced by systemic administration of cisplatin is reduced by concomitant administration of melanocortins, like alpha-melanocyte stimulating hormone (alpha-MSH). However, these experiments were ham

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4c50a4b9e1735ec74360ecb1a93eda
https://doi.org/10.1016/s0378-5955(03)00080-7

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Perilymphatic application of cisplatin over several days in albino guinea pigs: dose-dependency of electrophysiological and morphological effects

Autor: Stephen O'Leary, Frank P.T. Hamers, Guido F. Smoorenburg, John C.M.J. de Groot, Sjaak F.L. Klis

Publikováno v: Hearing Research. 154:135-145

Cisplatin, at 0, 3, 30 or 300 microg/ml in saline, was applied to the scala tympani of the cochlea of guinea pigs via osmotic mini-pumps, operating at a pump rate of 0.5 microl/h. Electrocochleographic recordings were made from an implanted round win

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6239b4ccf79264e7e2c78cb7a2f1b999
https://doi.org/10.1016/s0378-5955(01)00232-5

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Local application of collagen containing brain-derived neurotrophic factor decreases the loss of function after spinal cord injury in the adult rat

Autor: Peter R. Bär, Frank P.T. Hamers, E.A.J. Joosten, Didier Martin, Alex J. Lankhorst, D.A. Houweling, J. T. H. Van Asseldonk

Publikováno v: Neuroscience Letters. 251:193-196

We studied the effect of local application of brain-derived neurotrophic factor (BDNF) on functional recovery after dorsal spinal cord transection in the adult rat. BDNF was applied at the site of the lesion in rat tail collagen type I. Locomotion wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da41054f39ccfab8469a08059cb023fb
https://doi.org/10.1016/s0304-3940(98)00536-9

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