Zobrazeno 1 - 10
of 403
pro vyhledávání: '"Frank P Luyten"'
Autor:
Sara Caxaria, Nikolaos Kouvatsos, Suzanne E Eldridge, Mario Alvarez‐Fallas, Anne‐Sophie Thorup, Daniela Cici, Aida Barawi, Ammaarah Arshed, Danielle Strachan, Giulia Carletti, Xinying Huang, Sabah Bharde, Melody Deniz, Jacob Wilson, Bethan L Thomas, Costantino Pitzalis, Francesco Paolo Cantatore, Manasi Sayilekshmy, Shafaq Sikandar, Frank P Luyten, Thomas Pap, Joanna C Sherwood, Anthony J Day, Francesco Dell'Accio
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 1, Pp n/a-n/a (2023)
Abstract We showed that the chemokine receptor C‐X‐C Motif Chemokine Receptor 2 (CXCR2) is essential for cartilage homeostasis. Here, we reveal that the CXCR2 ligand granulocyte chemotactic protein 2 (GCP‐2) was expressed, during embryonic deve
Externí odkaz:
https://doaj.org/article/c6ccca64be374eba90196cda5f86dbe7
Autor:
Tine Peeters, Silvia Monteagudo, Przemko Tylzanowski, Frank P Luyten, Rik Lories, Frédéric Cailotto
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198104 (2018)
Tissue calcification is an important physiological process required for the normal structure and function of bone. However, ectopic or excessive calcification contributes to diseases such as chondrocalcinosis, to calcium deposits in the skin or to va
Externí odkaz:
https://doaj.org/article/ba313acb11744d23bb5a747a7d428687
Autor:
Yann Guyot, Bart Smeets, Tim Odenthal, Ramesh Subramani, Frank P Luyten, Herman Ramon, Ioannis Papantoniou, Liesbet Geris
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 9, p e1005108 (2016)
Perfusion bioreactors regulate flow conditions in order to provide cells with oxygen, nutrients and flow-associated mechanical stimuli. Locally, these flow conditions can vary depending on the scaffold geometry, cellular confluency and amount of extr
Externí odkaz:
https://doaj.org/article/2fdd0afc315641f69d418498a36e6334
Autor:
Johan Kerkhofs, Jeroen Leijten, Johanna Bolander, Frank P Luyten, Janine N Post, Liesbet Geris
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0162052 (2016)
Differentiation of chondrocytes towards hypertrophy is a natural process whose control is essential in endochondral bone formation. It is additionally thought to play a role in several pathophysiological processes, with osteoarthritis being a promine
Externí odkaz:
https://doaj.org/article/f06609b9949e43fb881d8c672ccb6bcd
Autor:
Maarten Sonnaert, Greet Kerckhofs, Ioannis Papantoniou, Sandra Van Vlierberghe, Veerle Boterberg, Peter Dubruel, Frank P Luyten, Jan Schrooten, Liesbet Geris
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130227 (2015)
To progress the fields of tissue engineering (TE) and regenerative medicine, development of quantitative methods for non-invasive three dimensional characterization of engineered constructs (i.e. cells/tissue combined with scaffolds) becomes essentia
Externí odkaz:
https://doaj.org/article/f4442ac784f1421ca43e2876ee4a9e7e
Autor:
Janak L Pathak, Astrid D Bakker, Patrick Verschueren, Willem F Lems, Frank P Luyten, Jenneke Klein-Nulend, Nathalie Bravenboer
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131041 (2015)
Generalized osteoporosis is common in patients with inflammatory diseases, possibly because of circulating inflammatory factors that affect osteoblast and osteoclast formation and activity. Serum levels of the inflammatory factors CXCL8 and CCL20 are
Externí odkaz:
https://doaj.org/article/15d6e0d53a1247208e664a1a2c866c95
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136875 (2015)
The use of a 3D perfusion culture environment for stem cell expansion has been shown to be beneficial for maintenance of the original cell functionality but due to several system inherent characteristics such as the presence of extracellular matrix,
Externí odkaz:
https://doaj.org/article/1139deed3e374e60a411fbb9f17e7d3e
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110484 (2014)
GPR22 is an orphan G protein-coupled receptor (GPCR). Since the ligand of the receptor is currently unknown, its biological function has not been investigated in depth. Many GPCRs and their intracellular effectors are targeted to cilia. Cilia are hig
Externí odkaz:
https://doaj.org/article/c4ecaab419e3465c82edf996c8c13cc6
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34729 (2012)
During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a large-sc
Externí odkaz:
https://doaj.org/article/3587aac68a6c42ef9fc3ed50a70e8600
Autor:
Ellen De Langhe, Greetje Vande Velde, Jeroen Hostens, Uwe Himmelreich, Benoit Nemery, Frank P Luyten, Jeroen Vanoirbeek, Rik J Lories
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43123 (2012)
BACKGROUND: In vivo high-resolution micro-computed tomography allows for longitudinal image-based measurements in animal models of lung disease. The combination of repetitive high resolution imaging with fully automated quantitative image analysis in
Externí odkaz:
https://doaj.org/article/76759d4abc9e4212b7c82f86d9e0fe84