Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Frank Oellien"'
Autor:
Lise I. Loberg, Meha Chhaya, Alexander Ibraghimov, Edit Tarcsa, Andreas Striebinger, Andreas Popp, Lili Huang, Frank Oellien, Stefan Barghorn
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
ABT-736 is a humanized monoclonal antibody generated to target a specific conformation of the amyloid-beta (Aβ) protein oligomer. Development of ABT-736 for Alzheimer’s disease was discontinued due to severe adverse effects (AEs) observed in cynom
Externí odkaz:
https://doaj.org/article/54871d30e40440c9ae5713239f79f81b
Autor:
Mathias Beig, Frank Oellien, Linnéa Garoff, Sandra Noack, R Luise Krauth-Siegel, Paul M Selzer
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003773 (2015)
With the goal to identify novel trypanothione reductase (TR) inhibitors, we performed a combination of in vitro and in silico screening approaches. Starting from a highly diverse compound set of 2,816 compounds, 21 novel TR inhibiting compounds could
Externí odkaz:
https://doaj.org/article/463f349fba974068be48d4dabecdaafa
Autor:
Conor R Caffrey, Andreas Rohwer, Frank Oellien, Richard J Marhöfer, Simon Braschi, Guilherme Oliveira, James H McKerrow, Paul M Selzer
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4413 (2009)
Schistosomiasis is a prevalent and chronic helmintic disease in tropical regions. Treatment and control relies on chemotherapy with just one drug, praziquantel and this reliance is of concern should clinically relevant drug resistance emerge and spre
Externí odkaz:
https://doaj.org/article/6f89ee6c78bd429a904d5fb89455d660
Autor:
Andreas Popp, Alexander Ibraghimov, Lise I. Loberg, Stefan Barghorn, Lili Huang, Meha Chhaya, Andreas Striebinger, Frank Oellien, Edit Tarcsa
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
ABT-736 is a humanized monoclonal antibody generated to target a specific conformation of the amyloid-beta (Aβ) protein oligomer. Development of ABT-736 for Alzheimer’s disease was discontinued due to severe adverse effects (AEs) observed in cynom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4ba4fc0ee4831893a9c164718462f6
http://europepmc.org/articles/PMC7894423
http://europepmc.org/articles/PMC7894423
Publikováno v:
Journal of chemical information and modeling. 60(10)
The efflux transporter P-glycoprotein (P-gp) is responsible for the extrusion of a wide variety of molecules, including drug molecules, from the cell. Therefore, P-gp-mediated efflux transport limits the bioavailability of drugs. To identify potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb87562bba564fd886290cc402d4f141
https://pubmed.ncbi.nlm.nih.gov/32786699
https://pubmed.ncbi.nlm.nih.gov/32786699
Publikováno v:
Chemistry – A European Journal. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b60a9a54fbe3d62465687cb35fa2bbc7
https://doi.org/10.1002/chem.201886864
https://doi.org/10.1002/chem.201886864
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 24(68)
Late-stage functionalization of lead compounds is of high interest in drug discovery since it offers an easy access to metabolites and derivatives of a lead compound without the need to redesign an often long multistep synthesis. Owing to their high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb3b0714b988280c6831033381ff55c
https://pubmed.ncbi.nlm.nih.gov/30451324
https://pubmed.ncbi.nlm.nih.gov/30451324
Publikováno v:
Trypanosomatid Diseases: Molecular Routes to Drug Discovery
Trypanosomes and Leishmania, the causative agents of African sleeping sickness, Chagas disease, and Leishmaniasis, are responsible for over half a million human deaths per year in subtropical and tropical regions around the world. Only a handful of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b5c03dae6d919f7ad77c959f0af21ef
https://doi.org/10.1002/9783527670383.ch21
https://doi.org/10.1002/9783527670383.ch21
Publikováno v:
Future Medicinal Chemistry. 3:1011-1025
For centuries infectious diseases were the scourge of humanity, overcome only by the discovery of vaccination and penicillin. With an armamentarium of effective antibiotics, vaccines and drugs at hand, infectious diseases for many years were consider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed429b00cbd2a3ad620ed34e93b4bbb
https://doi.org/10.4155/fmc.11.60
https://doi.org/10.4155/fmc.11.60
Autor:
Frank Oellien, Paul M. Selzer, Sandra Noack, Linnéa Garoff, Mathias Beig, R. Luise Krauth-Siegel
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003773 (2015)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
With the goal to identify novel trypanothione reductase (TR) inhibitors, we performed a combination of in vitro and in silico screening approaches. Starting from a highly diverse compound set of 2,816 compounds, 21 novel TR inhibiting compounds could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f9ef84abce20df39ed4ced6c120f86
http://europepmc.org/articles/PMC4456413?pdf=render
http://europepmc.org/articles/PMC4456413?pdf=render